Adrenaline

Inducing highs of excitement, anger, and terror, adrenaline fuels the extremes of human experience. A rush empowers superhuman feats in emergencies. Risk-taking junkies seek to replicate this feeling in dangerous recreations. And a surge may literally scare us to death. Adrenaline brings us up to speed on the fascinating molecule that drives some of our most potent experiences. Adrenaline was discovered in 1894 and quickly made its way out of the lab into clinics around the world. In this engrossing account, Brian Hoffman examines adrenaline in all its capacities, from a vital regulator of physiological functions to the subject of Nobel Prize–winning breakthroughs. Because its biochemical pathways are prototypical, adrenaline has had widespread application in hormone research leading to the development of powerful new drugs. Hoffman introduces the scientists to whom we owe our understanding, tracing the paths of their discoveries and aspirations and allowing us to appreciate the crucial role adrenaline has played in pushing modern medicine forward. Hoffman also investigates the vivid, at times lurid, place adrenaline occupies in the popular imagination, where accounts of its life-giving and lethal properties often leave the realm of fact. Famous as the catalyst of the “fight or flight” response, adrenaline has also received forensic attention as a perfect poison, untraceable in the bloodstream—and rumors persist of its power to revive the dead. True to the spirit of its topic, Adrenaline is a stimulating journey that reveals the truth behind adrenaline’s scientific importance and enduring popular appeal.

Sam Capra - brilliant CIA agent, loving husband, expectant father - loses everything that matters to him in a horrifying moment in London. An unknown enemy has set him up as a traitor. But that enemy has targeted the wrong man. Escaping from the CIA, Sam goes on a desperate hunt for the killer who stole his family and to save his kidnapped wife and child. But the destruction of Sam's life was only step one in an extraordinary plot - and now Sam Capra must become a new kind of hero.

This is the digital version of the printed book (Copyright © 2008). Adrenaline junkies, dead fish, project sluts, true believers, Lewis and Clark, template zombies . . . Most developers, testers, and managers on IT projects are pretty good at recognizing patterns of behavior and gut-level hunches, as in, “I sense that this project is headed for disaster.” But it has always been more difficult to transform these patterns and hunches into a usable form, something a team can debate, refine, and use. Until now. In Adrenaline Junkies and Template Zombies, the six principal consultants of The Atlantic Systems Guild present the patterns of behavior they most often observe at the dozens of IT firms they transform each year, around the world. The result is a quick-read guide to identifying nearly ninety typical scenarios, drawing on a combined one-hundred-and-fifty years of project management experience. Project by project, you’ll improve the accuracy of your hunches and your ability to act on them. The patterns are presented in an easy-reference format, with names designed to ease communication with your teammates. In just a few words, you can describe what’s happening on your project. Citing the patterns of behavior can help you quickly move those above and below you to the next step on your project. You’ll find classic patterns such as these: News Improvement Management by Mood Ring Piling On Rattle Yer Dags Natural Authority Food++ Fridge Door and more than eighty more! Not every pattern will be evident in your organization, and not every pattern is necessarily good or bad. However, you’ll find many patterns that will apply to your current and future assignments, even in the most ambiguous circumstances. When you assess your situation and follow your next hunch, you'll have the collective wisdom of six world-class consultants at your side.

This accessible work is the first in more than seventy-five years to discuss the many roles of adrenaline in regulating the "inner world" of the body. David S. Goldstein, an international authority and award-winning teacher, introduces new concepts concerning the nature of stress and distress across the body's regulatory systems. Discussing how the body's stress systems are coordinated, and how stress, by means of adrenaline, may affect the development, manifestations, and outcomes of chronic diseases, Goldstein challenges researchers and clinicians to use scientific integrative medicine to develop new ways to treat, prevent, and palliate disease. Goldstein explains why a former attorney general with Parkinson disease has a tendency to faint, why young astronauts in excellent physical shape cannot stand up when reexposed to Earth's gravity, why professional football players can collapse and die of heat shock during summer training camp, and why baseball players spit so much. Adrenaline and the Inner World is designed to supplement academic coursework in psychology, psychiatry, endocrinology, cardiology, complementary and alternative medicine, physiology, and biochemistry. It includes an extensive glossary.

The book examines the noradrenaline-emotional psyches (brain-blood barrier) somatic-adrenaline axis. It conceptually updates research advances, diagnostic techniques and therapeutic methods. The authors enhance their discussions with clear illustrations and explicative texts written for researchers, professionals, educators and students alike, which favour its selection as an essential overview of recent medical and scientific advances, allowing the reader to have the satisfaction of finding first-rate accounts of important work. Comparative studies between immediately obtained adrenal vein samples (AVS) and 15 minutes thereafter show that the stress reactions induced by catheter manipulation had an effect on serum cortisol and aldosterone values. A transient increase in cortisol release from both adrenal glands occurs in the majority of the patients who undergo AVS. This stress reaction can influence the assessment of both the selectivity of the catheterisation during the sequential AVS technique and the lateralisation of aldosteronoma bearing gland. The separation of noradrenaline (NA) at brain and adrenaline at blood functions as a homeostatic lame axis by the blood-brain barrier blocking adrenaline feedback in hypothalamic-pituitary-adrenal (HTPA). This leads to postulate an evolution adaptation for the brain dominance over body, which allows a psychoanalytic treatment to function to signal turn-off and return to circadian homeostasis. Decreased glucose could stress the HTPA axis and leads to decreasing metabolites and releasing Mg2+ for integration of the brain-tissue network. Mg2+ changes adenylyl cyclase (AC) from a Ca2+-AC complex to an Mg2+-AC form with responsiveness to NA for short-term memory. The cAMP generated has been postulated for consolidation of long-term memory.

Pituitary Adenylate Cyclase-Activating Polypeptide is the first volume to be written on the neuropeptide PACAP. It covers all domains of PACAP from molecular and cellular aspects to physiological activities and promises for new therapeutic strategies. Pituitary Adenylate Cyclase-Activating Polypeptide is the twentieth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.

Are you a thrill-seeker or a chill-seeker? A clinical psychologist lifts the lid on what makes adrenaline junkies tick.

'He is skilful. He is outspoken. He is Zlatan' New York Times 'He is an amazing talent, one of the best around' Pep Guardiola Football's most prolific and controversial goalscorer has nothing left to prove on the pitch. There is only one Zlatan. In the decade since his megaselling memoir I am Zlatan Ibrahimovic, he has played at Paris Saint-Germain (2012-2016), Manchester United (2016-2018), LA Galaxy (2018-2019) and Milan (2020-). This outrageous and hilarious follow-up is bursting with personal confessions and revealing anecdotes about the world's best players and managers. Packed with revelations, in Adrenaline we hear for the first time what Zlatan really thinks about his time in the Premier League and what it was like to score that glorious bicycle kick against England. We hear about the club he very nearly signed for, and see his hilarious run-ins with the French media - and the French in general, really. Plus so much more. Zlatan transports you into the world of top-flight football like no one else. Filled with revelations - including Zlatan's life lessons on happiness, friendship and love - you'll be talking about this book a long time after finishing it.