Advanced Statistics For Health Research

The book aims to provide both comprehensive reviews of the classical methods and an introduction to new developments in medical statistics. The topics range from meta analysis, clinical trial design, causal inference, personalized medicine to machine learning and next generation sequence analysis. Since the publication of the first edition, there have been tremendous advances in biostatistics and bioinformatics. The new edition tries to cover as many important emerging areas and reflect as much progress as possible. Many distinguished scholars, who greatly advanced their research areas in statistical methodology as well as practical applications, also have revised several chapters with relevant updates and written new ones from scratch.The new edition has been divided into four sections, including, Statistical Methods in Medicine and Epidemiology, Statistical Methods in Clinical Trials, Statistical Genetics, and General Methods. To reflect the rise of modern statistical genetics as one of the most fertile research areas since the publication of the first edition, the brand new section on Statistical Genetics includes entirely new chapters reflecting the state of the art in the field.Although tightly related, all the book chapters are self-contained and can be read independently. The book chapters intend to provide a convenient launch pad for readers interested in learning a specific topic, applying the related statistical methods in their scientific research and seeking the newest references for in-depth research.

"Advanced Statistics in Research: Reading, Understanding, and Writing Up Data Analysis Results" is the simple, nontechnical introduction to the most complex multivariate statistics presented in empirical research articles. "wwwStatsInResearch.com, " is a companion website that provides free sample chapters, exercises, and PowerPoint slides for students and teachers. A free 600-item test bank is available to instructors. "Advanced Statistics in Research" does not show how to "perform" statistical procedures--it shows how to read, understand, and interpret them, as they are typically presented in journal articles and research reports. It demystifies the sophisticated statistics that stop most readers cold: multiple regression, logistic regression, discriminant analysis, ANOVA, ANCOVA, MANOVA, factor analysis, path analysis, structural equation modeling, meta-analysis--and more. "Advanced Statistics in Research" assumes that you have never had a course in statistics. It begins at the beginning, with research design, central tendency, variability, z scores, and the normal curve. You will learn (or re-learn) the big-three results that are common to most procedures: statistical significance, confidence intervals, and effect size. Step-by-step, each chapter gently builds on earlier concepts. Matrix algebra is avoided, and complex topics are explained using simple, easy-to-understand examples. "Need help writing up your results?" Advanced Statistics in Research shows how data-analysis results can be summarized in text, tables, and figures according to APA format. You will see how to present the basics (e.g., means and standard deviations) as well as the advanced (e.g., factor patterns, post-hoc tests, path models, and more). "Advanced Statistics in Research" is appropriate as a textbook for graduate students and upper-level undergraduates (see supplementary materials at StatsInResearch.com). It also serves as a handy shelf reference for investigators and all consumers of research.

This book brings together the voices of leading experts in the frontiers of biostatistics, biomedicine, and the health sciences to discuss the statistical procedures, useful methods, and novel applications in biostatistics research. It also includes discussions of potential future directions of biomedicine and new statistical developments for health research, with the intent of stimulating research and fostering the interactions of scholars across health research related disciplines. Topics covered include: Health data analysis and applications to EHR data Clinical trials, FDR, and applications in health science Big network analytics and its applications in GWAS Survival analysis and functional data analysis Graphical modelling in genomic studies The book will be valuable to data scientists and statisticians who are working in biomedicine and health, other practitioners in the health sciences, and graduate students and researchers in biostatistics and health.

Advanced Statistics for Health Research provides a rigorous geometric understanding of models used in the analysis of health data, including linear and non-linear regression models, and supervised machine learning models. Models drawn from the health literature include: ordinary least squares, two-stage least squares, probits, logits, Cox regressions, duration modeling, quantile regression and random forest regression. Causal inference techniques from the health literature are presented including randomization, matching and propensity score matching, differences-in-differences, instrumental variables, regression discontinuity, and fixed effects analysis. Codes for the respective statistical techniques presented are given for STATA, SAS and R.

The explanation and implementation of statistical methods for themedical researcher or statistician remains an integral part ofmodern medical research. This book explains the use of experimentaland analytical biostatistics systems. Its accessible style allowsit to be used by the non-mathematician as a fundamental componentof successful research. Since the third edition, there have been many developments instatistical techniques. The fourth edition provides the medicalstatistician with an accessible guide to these techniques and toreflect the extent of their usage in medical research. The new edition takes a much more comprehensive approach to itssubject. There has been a radical reorganization of the text toimprove the continuity and cohesion of the presentation and toextend the scope by covering many new ideas now being introducedinto the analysis of medical research data. The authors have triedto maintain the modest level of mathematical exposition thatcharacterized the earlier editions, essentially confining themathematics to the statement of algebraic formulae rather thanpursuing mathematical proofs. Received the Highly Commended Certificate in the PublicHealth Category of the 2002 BMA BooksCompetition.

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Most medical researchers, whether clinical or non-clinical, receive some background in statistics as undergraduates. However, it is most often brief, a long time ago, and largely forgotten by the time it is needed. Furthermore, many introductory texts fall short of adequately explaining the underlying concepts of statistics, and often are divorced