Advances In Mesenchymal Stem Cells And Tissue Engineering

Advances in Tissue Engineering is a unique volume and the first of its kind to bring together leading names in the field of tissue engineering and stem cell research. A relatively young science, tissue engineering can be seen in both scientific and sociological contexts and successes in the field are now leading to clinical reality. This book attempts to define the path from basic science to practical application. A contribution from the UK Stem Cell Bank and opinions of venture capitalists offer a variety of viewpoints, and exciting new areas of stem cell biology are highlighted. With over fifty stellar contributors, this book presents the most up-to-date information in this very topical and exciting field.

The fourth volume in this series is a proceedings volume based on papers presented at the 5th Innovations in Regenerative Medicine and Cancer Research conference. Chapters are written by some of the most innovative minds in stem cell and tissue engineering research, and provide a comprehensive overview of papers from the most recent conference. The volume addresses tissue engineering principles and applications, including current trends and challenges, as well as future directions. Cutting edge topics of interest include production of functional tissues, vascularization and immune responses, and functionalization of scaffolds. Volumes in this series are invaluable resources for active researchers, clinicians, and professionals in industry, as well as students across a broad range of fields.

A cutting-edge look at the application of micro and nanotechnologies in regenerative medicine The area at the interface of micro/nanotechnology and stem cells/tissue engineering has seen an explosion of activity in recent years. This book provides a much-needed overview of these exciting developments, covering all aspects of micro and nanotechnologies, from the fundamental principles to the latest research to applications in regenerative medicine. Written and edited by the top researchers in the field, Micro and Nanotechnologies in Engineering Stem Cells and Tissues describes advances in material systems along with current techniques available for cell, tissue, and organ studies. Readers will gain tremendous insight into the state of the art of stem cells and tissue engineering, and learn how to use the technology in their own research or clinical trials. Coverage includes: Technologies for controlling or regulating stem cell and tissue growth Various engineering approaches for stem cell, vascular tissue, and bone regeneration The design and processing of biocompatible polymers and other biomaterials Characterization of the interactions between cells and biomaterials Unrivaled among books of this kind, Micro and Nanotechnologies in Engineering Stem Cells and Tissues is the ultimate forward-looking reference for researchers in numerous disciplines, from engineering and materials science to biomedicine, and for anyone wishing to understand the trends in this transformative field.

This book is a unique guide to emerging stem cell technologies and the opportunities for their commercialisation. It provides in-depth analyses of the science, business, legal, and financing fundamentals of stem cell technologies, offering a holistic assessment of this emerging and dynamic segment of the field of regenerative medicine. • Reviews the very latest advances in the technology and business of stem cells used for therapy, research, and diagnostics • Identifies key challenges to the commercialisation of stem cell technology and avenues to overcome problems in the pipeline • Written by an expert team with extensive experience in the business, basic and applied science of stem cell research This comprehensive volume is essential reading for researchers in cell biology, biotechnology, regenerative medicine, and tissue engineering, including scientists and professionals, looking to enter commercial biotechnology fields.

Tissue engineering integrates knowledge and tools from biological sciences and engineering for tissue regeneration. A challenge for tissue engineering is to identify appropriate cell sources. The recent advancement of stem cell biology provides enormous opportunities to engineer stem cells for tissue engineering. The impact of stem cell technology on tissue engineering will be revolutionary. This book covers state-of-the-art knowledge on the potential of stem cells for the regeneration of a wide range of tissues and organs, including cardiovascular, musculoskeletal, neurological and skin tissues. The technology platforms for studying and engineering stem cells, such as hydrogel and biomaterials development, microfluidics system and microscale patterning, are also illustrated. Regulatory challenges and quality control for clinical translation are also detailed. This book provides an comprehensive update on the advancement in the field of stem cells and regenerative medicine, and serves as a valuable resource for both researchers and students. Contents: Tissue Engineering: From Basic Biology to Cell-Based Applications (R M Nerem)Recent Advances and Future Perspectives on Somatic Cell Reprogramming (K-Y Kim & I-H Park)Hematopoietic Stem Cells (J J Trowbridge)Mesenchymal Stem Cells for Tissue Regeneration (N F Huang & S Li)Delivery Vehicles for Deploying Mesenchymal Stem Cells in Tissue Repair (M S Friedman & J K Leach)Stem Cells for Cardiac Tissue Engineering (J L Young et al.)Cardiovascular System: Stem Cells in Tissue-Engineered Blood Vessels (R Sawh-Martinez et al.)Stem Cells for Vascular Regeneration: An Engineering Approach (L E Dickinson & S Gerecht)Stem Cells and Wound Repair (S H Ko et al.)Engineering Cartilage: From Materials to Small Molecules (J M Coburn & J H Elisseeff)Adult Stem Cells for Articular Cartilage Tissue Engineering (S Saha et al.)Stem Cells for Disc Repair (A A Allon et al.)Skeletal Tissue Engineering: Progress and Prospects (N J Panetta et al.)Clinical Applications of a Stem Cell Based Therapy for Oral Bone Reconstruction (B McAllister & K Haghighat)Therapeutic Strategies for Repairing the Injured Spinal Cord Using Stem Cells (M S Beattie & J C Bresnahan)Potential of Tissue Engineering and Neural Stem Cells in the Understanding and Treatment of Neurodegenerative Diseases (C Auclair-Daigle & F Berthod)High-Throughput Systems for Stem Cell Engineering (D A Brafman et al.)Microscale Technologies for Tissue Engineering and Stem Cell Differentiation (J W Nichol et al.)Quality Control of Autologous Cell- and Tissue-Based Therapies (N Dusserre et al.)Regulatory Challenges for Cell-Based Therapeutics (T McAllister et al.) Readership: Life science scientists; biomedical researchers; cell biologists; academics, postgraduate students and advanced undergraduate students in cell biology, biochemistry and genetics; surgeons; clinicians; biotechnology and pharmaceutical industry professionals. Keywords: Stem Cells;Tissue Engineering;Regenerative Medicine;Biotechnology;Cell EngineeringReview:0

Stem cells, tissue engineering and regenerative medicine are fast moving fields with vastly transformative implications for the future of health care and capital markets. This book will show the state of the art in the translational fields of stem cell biology, tissue engineering and regenerative medicine. The state of developments in specific organ systems, where novel solutions to organ failure are badly needed such as the lungs, kidney and so forth, are discussed in various chapters. These present and future advances are placed in the context of the overall field, offering a comprehensive and quick up-to-date drink from the fountain of knowledge in this rapidly emerging field. This book provides an investigator-level overview of the current field accessible to the educated scientific generalist as well as a college educated readership, undergraduates and science writers, educators and professionals of all kinds. Contents:Developmental Biology, Regenerative Medicine and Stem Cells: The Hope Machine is Justified (David Warburton)Towards Broader Approaches to Stem Cell Signaling and Therapeutics (Edwin Jesudason)Pluripotent Stem Cells from the Early Embryo (Claire E Cuddy and Martin F Pera)The First Cell Fate Decision During Mammalian Development (Melanie D White and Nicolas Plachta)Asymmetric Cell Divisions of Stem/Progenitor Cells (Ahmed HK El-Hashash)Microenvironmental Modulation of Stem Cell Differentiation with Focus on the Lung (Shimon Lecht, Collin T Stabler, Seda Karamil, Athanasios Mantalaris, Ali Samadikuchaksaraei, Julia M Polak and Peter I Lelkes)Smart Matrices for Distal Lung Tissue Engineering (Mark J Mondrinos and Peter I Lelkes)Skin Stem Cells and Their Roles in Skin Regeneration and Disorders (Chao-Kai Hsu, Chao-Chun Yang and Shyh-Jou Shieh)Stem Cell Recruitment and Impact in Skin Repair and Regeneration (Tim Hsu, Tai-Lan Tuan and Yun-Shain Lee)Epigenetic and Environmental Regulation of Skin Appendage Regeneration (Ting-Xin Jiang, Chih-Chiang Chen, Michael W Hughes, Cheng-Ming Chuong and Randall Widelitz)Cranial Neural Crest: An Extraordinarily Migratory and Multipotent Embryonic Cell Population (Samuel G Cox and J Gage Crump)Modeling Neurodegenerative Diseases and Neurodevelopmental Disorders with Reprogrammed Cells (Kate E Galloway and Justin K Ichida)Cytokine Regulation of Intestinal Stem Cells (Philip E Dubé, Unice J K Soh and D Brent Polk)The Intestinal Stem Cell Niche and Its Regulation by ErbB Growth Factor Receptors (Dana Almohazey and Mark R Frey)Tissue Engineering: Intestine (Avafia Y Dossa, Kathy A Schall, Tracy C Grikscheit and Christopher P Gayer)Liver Stem and Progenitor Cells in Development, Disease and Regenerative Medicine (Nirmala Mavila and Kasper S Wang)Lung Mesenchymal Stem Cells (Wei Shi)FGF Signaling in Lung Stem and Progenitor Cells (Soula Danopoulos and Denise Al Alam)Bioengineering Distal Airways (Christine Finck and Todd Jensen)The Isolation and Molecular Characterization of Cancer Stem Cells (Aggressive Endophenotypes) in Individual Lung Cancers (Raj K Batra, Scott Oh and Saroj Basak)Mesenchymal Stromal Cell-Based Therapies for Lung Diseases and Critical Illnesses (Fernanda Cruz, Patricia RM Rocco and Daniel J Weiss)Heart Regeneration and Repair: What We Have Learned from Model Organisms (Laurent Gamba, Michael R Harrison and Ching-Ling Lien)Leveraging Structure-Based Rational Drug Design and Nanotechnology to Destroy Leukemic Stem Cells (Fatih M Uckun, Jianjun Cheng, Cheney Mao and Sanjive Qazi)Placenta-Derived Stem Cells: Development and Preclinical Applications for Regenerative Medicine (Jennifer Izumi Divine, Hee Kyung Jung and Toshio Miki)Stem Cells in the Real World: Environmental Impacts (Theresa M Bastain, Lu Gao and Frank D Gilliland)Establishing a Research Grade Human Pluripotent Stem Cell Laboratory (Laura-Marie Nucho and Victoria Fox) Readership: Stem cell and tissue engineering scientists, patient advocates, educated laypeople, high school science students, undergraduate students, graduate students, physicians and surgeons. Key Features:This book presents up-to-date latest breakthroughs and near future applicationsBench to bedsideThis book features potential curesKeywords:Stem Cells;Tissue Engineering;Regenerative Medicine

"Fundamentals of Tissue Engineering and Regenerative Medicine" provides a complete overview of the state of the art in tissue engineering and regenerative medicine. Tissue engineering has grown tremendously during the past decade. Advances in genetic medicine and stem cell technology have significantly improved the potential to influence cell and tissue performance, and have recently expanded the field towards regenerative medicine. In recent years a number of approaches have been used routinely in daily clinical practice, others have been introduced in clinical studies, and multitudes are in the preclinical testing phase. Because of these developments, there is a need to provide comprehensive and detailed information for researchers and clinicians on this rapidly expanding field. This book offers, in a single volume, the prerequisites of a comprehensive understanding of tissue engineering and regenerative medicine. The book is conceptualized according to a didactic approach (general aspects: social, economic, and ethical considerations; basic biological aspects of regenerative medicine: stem cell medicine, biomolecules, genetic engineering; classic methods of tissue engineering: cell, tissue, organ culture; biotechnological issues: scaffolds; bioreactors, laboratory work; and an extended medical discipline oriented approach: review of clinical use in the various medical specialties). The content of the book, written in 68 chapters by the world’s leading research and clinical specialists in their discipline, represents therefore the recent intellect, experience, and state of this bio-medical field.

Stem Cells—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Adult Stem Cells. The editors have built Stem Cells—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Adult Stem Cells in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Stem Cells—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.