Aggregation Of Therapeutic Proteins
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Aggregation of Therapeutic Proteins
Author | : Wei Wang,Christopher J. Roberts |
Publsiher | : John Wiley & Sons |
Total Pages | : 400 |
Release | : 2010-12-28 |
Genre | : Medical |
ISBN | : 9781118043585 |
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This book gives pharmaceutical scientists an up-to-date resource on protein aggregation and its consequences, and available methods to control or slow down the aggregation process. While significant progress has been made in the past decade, the current understanding of protein aggregation and its consequences is still immature. Prevention or even moderate inhibition of protein aggregation has been mostly experimental. The knowledge in this book can greatly help pharmaceutical scientists in the development of therapeutic proteins, and also instigate further scientific investigations in this area. This book fills such a need by providing an overview on the causes, consequences, characterization, and control of the aggregation of therapeutic proteins.
Analysis of Aggregates and Particles in Protein Pharmaceuticals
Author | : Hanns-Christian Mahler,Wim Jiskoot |
Publsiher | : John Wiley & Sons |
Total Pages | : 480 |
Release | : 2011-12-20 |
Genre | : Medical |
ISBN | : 9781118150566 |
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This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy.
Therapeutic Proteins
Author | : Vladimir Voynov,Justin A. Caravella |
Publsiher | : Humana Press |
Total Pages | : 516 |
Release | : 2016-05-01 |
Genre | : Medical |
ISBN | : 1493959492 |
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Emphasizing the newest developments in the field, this volume presents detailed methodswith added emphasison therapeutic protein discovery. It features key tips and valuable implementation advice to ensure successful results."
Therapeutic Proteins
Author | : C. Mark Smales,David C. James |
Publsiher | : Springer Science & Business Media |
Total Pages | : 481 |
Release | : 2008-02-04 |
Genre | : Science |
ISBN | : 9781592599226 |
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With the recent completion of the sequencing of the human genome, it is widely anticipated that the number of potential new protein drugs and targets will escalate at an even greater rate than that observed in recent years. However, identification of a potential target is only part of the process in developing these new next generation protein-based “drugs” that are increasingly being used to treat human disease. Once a potential protein drug has been identified, the next rate-limiting step on the road to development is the production of sufficient authentic material for testing, charact- ization, clinical trials, and so on. If a protein drug does actually make it through this lengthy and costly process, methodology that allows the production of the protein on a scale large enough to meet demand must be implemented. Furthermore, large-scale production must not compromise the authenticity of the final product. It is also nec- sary to have robust methods for the purification, characterization, viral inactivation and continued testing of the authenticity of the final protein product and to be able to formulate it in a manner that retains both its biological activity and lends itself to easy administration. Therapeutic Proteins: Methods and Protocols covers all aspects of protein drug production downstream of the discovery stage. This volume contains contributions from leaders in the field of therapeutic protein expression, purification, characterization, f- mulation, and viral inactivation.
Inhibition of Therapeutic Protein Aggregation by Cyclodextrins
Author | : Tim Serno |
Publsiher | : Unknown |
Total Pages | : 221 |
Release | : 2011 |
Genre | : Electronic Book |
ISBN | : 3869556315 |
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Protein Pharmaceuticals
Author | : Hanns-Christian Mahler,Gerrit Borchard,Henrik Luer Luessen |
Publsiher | : Unknown |
Total Pages | : 464 |
Release | : 2010 |
Genre | : Aufsatzsammlung |
ISBN | : 3871933821 |
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Fusion Protein Technologies for Biopharmaceuticals
Author | : Stefan R. Schmidt |
Publsiher | : John Wiley & Sons |
Total Pages | : 995 |
Release | : 2013-01-28 |
Genre | : Medical |
ISBN | : 9781118354582 |
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The state of the art in biopharmaceutical FUSION PROTEIN DESIGN Fusion proteins belong to the most lucrative biotech drugs—with Enbrel® being one of the best-selling biologics worldwide. Enbrel® represents a milestone of modern therapies just as Humulin®, the first therapeutic recombinant protein for human use, approved by the FDA in 1982 and Orthoclone® the first monoclonal antibody reaching the market in 1986. These first generation molecules were soon followed by a plethora of recombinant copies of natural human proteins, and in 1998, the first de novo designed fusion protein was launched. Fusion Protein Technologies for Biopharmaceuticals examines the state of the art in developing fusion proteins for biopharmaceuticals, shedding light on the immense potential inherent in fusion protein design and functionality. A wide pantheon of international scientists and researchers deliver a comprehensive and complete overview of therapeutic fusion proteins, combining the success stories of marketed drugs with the dynamic preclinical and clinical research into novel drugs designed for as yet unmet medical needs. The book covers the major types of fusion proteins—receptor-traps, immunotoxins, Fc-fusions and peptibodies—while also detailing the approaches for developing, delivering, and improving the stability of fusion proteins. The main body of the book contains three large sections that address issues key to this specialty: strategies for extending the plasma half life, the design of toxic proteins, and utilizing fusion proteins for ultra specific targeting. The book concludes with novel concepts in this field, including examples of highly relevant multifunctional antibodies. Detailing the innovative science, commercial realities, and brilliant potential of fusion protein therapeutics, Fusion Protein Technologies for Biopharmaceuticals is a must for pharmaceutical scientists, biochemists, medicinal chemists, molecular biologists, pharmacologists, and genetic engineers interested in determining the shape of innovation in the world of biopharmaceuticals.
Analysis of Aggregates and Particles in Protein Pharmaceuticals
Author | : Hanns-Christian Mahler,Wim Jiskoot |
Publsiher | : John Wiley & Sons |
Total Pages | : 480 |
Release | : 2012-01-24 |
Genre | : Medical |
ISBN | : 9780470497180 |
Download Analysis of Aggregates and Particles in Protein Pharmaceuticals Book in PDF, Epub and Kindle
This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy.