Allergy And Tissue Metabolism

Allergy and Tissue Metabolism covers some of the more important features of the state of knowledge in the relevant areas of allergy and tissue metabolism. This book is composed of nine chapters, and starts with a survey of the link between immune system and allergic diseases. The subsequent chapters deal with the evaluation of anaphylactic shock mechanisms using some animal models and the relationship between eosinophils and anaphylaxis. These topics are followed by discussions on the role of histamine, bradykinin, and serotonin in allergy. A chapter examines the slow reacting substance of anaphylaxis. The final chapters consider the therapeutic management of allergic diseases. This book is of value to allergists, allergologists, immunologists, and researchers and workers in the allied fields.

llergic Contact Dermatitis assesses the potential effects of xenobiotic metabolism and protein reactivity on toxicity. It reviews current knowledge of percutaneous absorption and skin metabolism and includes discussion of the xenobiotics themselves. It answers questions such as: How does sensitisation relate to protein reactivity and levels of metabolism? How we can identify potential hazards in food, cosmetics and pharmaceuticals etc? In a world where people are becoming increasingly aware of their allergies, this up to date one-stop reference will prove an invaluable addition to the shelves of any researcher in academia, government, regulatory bodies, public health officials and, of course, the food, cosmetics and pharmaceuticals industries will find the book to be of particular relevance.

More than 50 million Americans, one out of five, suffer from hay fever, asthma, and other allergic diseases. Many of these conditions are caused by exposure to allergens in indoor environments such as the house, work, and schoolâ€"where we spend as much as 98 percent of our time. Developed by medical, public health, and engineering professionals working together, this unique volume summarizes what is known about indoor allergens, how they affect human health, the magnitude of their effect on various populations, and how they can be controlled. The book addresses controversies, recommends research directions, and suggests how to assist and educate allergy patients, as well as professionals. Indoor Allergens presents a wealth of information about common indoor allergens and their varying effects, from significant hay fever to life-threatening asthma. The volume discusses sources of allergens, from fungi and dust mites to allergenic chemicals, plants, and animals, and examines practical measures for their control. Indoor Allergens discusses how the human airway and immune system respond to inhaled allergens and assesses patient testing methods, covering the importance of the patient's medical history and outlining procedures and approaches to interpretation for skin tests, in vitro diagnostic tests, and tests of patients' pulmonary function. This comprehensive and practical volume will be important to allergists and other health care providers; public health professionals; specialists in building design, construction, and maintenance; faculty and students in public health; and interested allergy patients.

Over the past 20 years, public concerns have grown in response to the apparent rising prevalence of food allergy and related atopic conditions, such as eczema. Although evidence on the true prevalence of food allergy is complicated by insufficient or inconsistent data and studies with variable methodologies, many health care experts who care for patients agree that a real increase in food allergy has occurred and that it is unlikely to be due simply to an increase in awareness and better tools for diagnosis. Many stakeholders are concerned about these increases, including the general public, policy makers, regulatory agencies, the food industry, scientists, clinicians, and especially families of children and young people suffering from food allergy. At the present time, however, despite a mounting body of data on the prevalence, health consequences, and associated costs of food allergy, this chronic disease has not garnered the level of societal attention that it warrants. Moreover, for patients and families at risk, recommendations and guidelines have not been clear about preventing exposure or the onset of reactions or for managing this disease. Finding a Path to Safety in Food Allergy examines critical issues related to food allergy, including the prevalence and severity of food allergy and its impact on affected individuals, families, and communities; and current understanding of food allergy as a disease, and in diagnostics, treatments, prevention, and public policy. This report seeks to: clarify the nature of the disease, its causes, and its current management; highlight gaps in knowledge; encourage the implementation of management tools at many levels and among many stakeholders; and delineate a roadmap to safety for those who have, or are at risk of developing, food allergy, as well as for others in society who are responsible for public health.

This unique book is a first-of-its-kind resource, comprehensively guiding readers through the epidemiology, pathophysiology, recent diagnostic criteria, and management options for patients with Food Protein-Induced Enterocolitis Syndrome (FPIES). Food-Protein Induced Enterocolitis Syndrome: Diagnosis and Management opens with a historical perspective of this condition, before moving into discussions of epidemiology and pathophysiology. FPIES can be difficult to diagnose as the symptoms overlap with multiple other conditions, and so clear differential diagnosis will be reviewed for both chronic FPIES, as well as acute FPIES. Later chapters are case-based, providing detailed multiple perspectives on the diagnosis and management of FPIES in patients with varying complicating factors and severity. Later chapters will tackle issues of quality of life in patient care, nutritional management for patients, and discussing working with parents and families to improve communication and at-home care. Parents, families and caregivers will also find chapters useful and relatable. A final chapter will look to the future of FPIES, addressing new research, guidelines, and implications for clinicians working with pediatric patients with FPIES, and for their families. Concise and practical, this book will be an ideal reference for allergists, pediatricians, family practice clinicians, gastroenterologists, nutritionists, and all other health care providers who encounter FPIES, and assist them in providing up-to-date, quality care for pediatric patients affected by this condition.

The clinical practice of anesthesia has undergone many advances in the past few years, making this the perfect time for a new state-of-the-art anesthesia textbook for practitioners and trainees. The goal of this book is to provide a modern, clinically focused textbook giving rapid access to comprehensive, succinct knowledge from experts in the field. All clinical topics of relevance to anesthesiology are organized into 29 sections consisting of more than 180 chapters. The print version contains 166 chapters that cover all of the essential clinical topics, while an additional 17 chapters on subjects of interest to the more advanced practitioner can be freely accessed at www.cambridge.org/vacanti. Newer techniques such as ultrasound nerve blocks, robotic surgery and transesophageal echocardiography are included, and numerous illustrations and tables assist the reader in rapidly assimilating key information. This authoritative text is edited by distinguished Harvard Medical School faculty, with contributors from many of the leading academic anesthesiology departments in the United States and an introduction from Dr S. R. Mallampati. This book is your essential companion when preparing for board review and recertification exams and in your daily clinical practice.

Keeping up to date with advances in comprehensive ophthalmology and in the ophthalmic sub-specialties is extremely difficult because of the accelerating rapidity with which new information and technology become available and the diminishing time and opportunity for practitioners and trainees to read and learn. The first edition of Albert and Jakobiec's Principles and Practice (1994) was conceived with the idea of utilizing an electronic, updated version in which the chapters were revised by the chapter authors on an annual or semi-annual basis, but the technology was not sufficiently advanced to achieve this goal. Subsequent editions (2000 and 2008) were organized by Saunders and the last published by Elsevier (of which Springer has obtained the complete rights to move forward with the 4th edition). For nearly three decades, this text has provided its readers with authoritative and comprehensive coverage of clinical ophthalmology, written and edited by a group of authors who represented a "Who's Who" in ophthalmology. By using Springer's Meteor platform, with its ability to allow authors and editors access to updating their chapters online annually/semi-annually, and with the recruitment of select chapter authors, this work's usefulness as the standard text in ophthalmology will be maintained and expanded upon by Springer. The 4th edition of this comprehensive and authoritative text is written by hundreds of the most distinguished authorities from around the world and edited by four leaders in the field, providing today's best answers to every question that arises in ophthalmology practice. Richly illustrated with thousands of high quality, full color, clinically-relevant images, Albert and Jakobiec's Principles and Practice of Ophthalmology, 4th Edition covers every scientific and clinical principle in ophthalmology, ensuring that the reader will always be able to find the guidance needed to diagnose and manage patients' ocular problems and meet today's standards of care. Written for practicing ophthalmologists and trainees, this book delivers in-depth guidance on new diagnostic approaches, operative techniques, and treatment options, as well as coherent explanations of new scientific concept and its clinical importance. The 4th edition will prove to be the source every practicing clinician needs to efficiently and confidently overcome any clinical challenge they may face. Updates include new chapters on anterior and posterior segment diseases, as well as chapters more focused on treatment, plus thousands of new, high-quality, color images and illustrations, updated references, and information on the most cutting-edge technology used by clinicians in their practices today. Additionally, readers will enjoy the same, user-friendly, full-color design they remember from the previous edition, complete with many at-a-glance summary tables, algorithms, boxes, and diagrams that allow the reader to locate the assistance needed more rapidly than ever. .

The type 2 immune response that develops during infectious disease has undergone major paradigm shifts in the last several years as new cell types and pathways have been identified. It is now clear that the type 2 immune response, characterized by elevations in specific cytokines, including IL-4, IL-5 and IL-13, is associated with helminth infections in both humans and mice. This response is complex and includes effector functions that mediate resistance, contributing to expulsion and in some cases destruction, of the parasite. But just as importantly, the type 2 immune response can also mediate tolerance mechanisms, which can mitigate tissue injury as these large multicellular parasites transit through vital organs. The tolerance mechanisms include both tissue repair and immune regulatory effects. These latter aspects of the helminth-induced type 2 immune response are increasingly recognized as a potential resource that can be mined for the development of novel immunotherapies that may enhance wound healing, control of autoimmune and inflammatory diseases and regulation of metabolic homeostasis. In this book, leading researchers in this exciting and dynamic field discuss the latest findings and emerging concepts, providing an intellectual framework that can be used as a basis for new discoveries and potentially new treatments for diseases associated with inflammation.