An Introduction To The History Of Chronobiology Volume 2

In three volumes, historian Jole Shackelford delineates the history of the study of biological rhythms—now widely known as chronobiology—from antiquity into the twentieth century. Perhaps the most well-known biological rhythm is the circadian rhythm, tied to the cycles of day and night and often referred to as the “body clock.” But there are many other biological rhythms, and although scientists and the natural philosophers who preceded them have long known about them, only in the past thirty years have a handful of pioneering scientists begun to study such rhythms in plants and animals seriously. Tracing the intellectual and institutional development of biological rhythm studies, Shackelford offers a meaningful, evidence-based account of a field that today holds great promise for applications in agriculture, health care, and public health. Volume 1 follows early biological observations and research, chiefly on plants; volume 2 turns to animal and human rhythms and the disciplinary contexts for chronobiological investigation; and volume 3 focuses primarily on twentieth-century researchers who modeled biological clocks and sought them out, including three molecular biologists whose work in determining clock mechanisms earned them a Nobel Prize in 2017.

In three volumes, historian Jole Shackelford delineates the history of the study of biological rhythms—now widely known as chronobiology—from antiquity into the twentieth century. Perhaps the most well-known biological rhythm is the circadian rhythm, tied to the cycles of day and night and often referred to as the “body clock.” But there are many other biological rhythms, and although scientists and the natural philosophers who preceded them have long known about them, only in the past thirty years have a handful of pioneering scientists begun to study such rhythms in plants and animals seriously. Tracing the intellectual and institutional development of biological rhythm studies, Shackelford offers a meaningful, evidence-based account of a field that today holds great promise for applications in agriculture, health care, and public health. Volume 1 follows early biological observations and research, chiefly on plants; volume 2 turns to animal and human rhythms and the disciplinary contexts for chronobiological investigation; and volume 3 focuses primarily on twentieth-century researchers who modeled biological clocks and sought them out, including three molecular biologists whose work in determining clock mechanisms earned them a Nobel Prize in 2017.

In three volumes, historian Jole Shackelford delineates the history of the study of biological rhythms—now widely known as chronobiology—from antiquity into the twentieth century. Perhaps the most well-known biological rhythm is the circadian rhythm, tied to the cycles of day and night and often referred to as the “body clock.” But there are many other biological rhythms, and although scientists and the natural philosophers who preceded them have long known about them, only in the past thirty years have a handful of pioneering scientists begun to study such rhythms in plants and animals seriously. Tracing the intellectual and institutional development of biological rhythm studies, Shackelford offers a meaningful, evidence-based account of a field that today holds great promise for applications in agriculture, health care, and public health. Volume 1 follows early biological observations and research, chiefly on plants; volume 2 turns to animal and human rhythms and the disciplinary contexts for chronobiological investigation; and volume 3 focuses primarily on twentieth-century researchers who modeled biological clocks and sought them out, including three molecular biologists whose work in determining clock mechanisms earned them a Nobel Prize in 2017.

This book represents the first in a two-volume set on biological rhythms. This volume focuses on supporting the claim that biological rhythms are universal and essential characteristics of living organisms, critical for proper functioning of any living system. The author begins by examining the potential reasons for the evolution of biological rhythms: (1) the need for complex, goal-oriented devices to control the timing of their activities; (2) the inherent tendency of feedback control systems to oscillate; and (3) the existence of stable and powerful geophysical cycles to which all organisms must adapt. To investigate the second reason, the author enlists the help of biomedical engineering students to develop mathematical models of various biological systems. One such model involves a typical endocrine feedback system. By adjusting various model parameters, it was found that creating a oscillation in any component of the model generated a rhythmic cascade that made the entire system oscillate. This same approach was used to show how daily light/dark cycles could cascade rhythmic patterns throughout ecosystems and within organisms. Following up on these results, the author discusses how the twin requirements of internal synchronization (precise temporal order necessary for the proper functioning of organisms as complex, goal-oriented devices) and external synchronization (aligning organisms' behavior and physiology with geophysical cycles) supported the evolution of biological clocks. The author then investigates the clock systems that evolved using both conceptual and mathematical models, with the assistance of Dr. Bahrad Sokhansanj, who contributes a chapter on mathematical formulations and models of rhythmic phenomena. With the ubiquity of biological rhythms established, the author suggests a new classification system: the F4LM approach (Function; Frequency; waveForm; Flexibility; Level of biological system expressing rhythms; and Mode of rhythm generation) to investigate biological rhythms. This approach is first used on the more familiar cardiac cycle and then on neural rhythms as exemplified and measured by the electroencephalogram. During the process of investigating neural cycles, the author finds yet another reason for the evolution of biological rhythms: physical constraints, such as those imposed upon long distance neural signaling. In addition, a common theme emerges of a select number of autorhythmic biological oscillators imposing coherent rhythmicity on a larger network or system. During the course of the volume, the author uses a variety of observations, models, experimental results, and arguments to support the original claim of the importance and universality of biological rhythms. In Volume 2, the author will move from the establishment of the critical nature of biological rhythms to how these phenomena may be used to improve human health, well-being, and productivity. In a sense, Volume 1 focuses on the chronobio aspect of chronobioengineering while Volume 2 investigates methods of translating this knowledge into applications, the engineering aspect of chronobioengineering. Table of Contents: Time and Time Again / Walking on Air: An Empirical Proof-of-Concept / Clock Tech, Part 1 / Clock Tech II From External to Internal Timers / Clock Tech III Rise of the CircaRhythms / The Circle Game: Mathematics, Models, and Rhythms / The Power of Circular Reasoning

We began as savages, and savagery has served us well—it got us where we are. But how do our tribal impulses, still in place and in play, fit in the highly complex, civilized world we inhabit today? This question, raised by thinkers from Freud to Lévi-Strauss, is fully explored in this book by the acclaimed anthropologist Robin Fox. It takes up what he sees as the main—and urgent—task of evolutionary science: not so much to explain what we do, as to explain what we do at our peril. Ranging from incest and arranged marriage to poetry and myth to human rights and pop icons, Fox sets out to show how a variety of human behaviors reveal traces of their tribal roots, and how this evolutionary past limits our capacity for action. Among the questions he raises: How real is our notion of time? Is there a human “right” to vengeance? Are we democratic by nature? Are cultural studies and fascism cousins under the skin? Is evolutionary history coming to an end—or just getting more interesting? In his famously informative and entertaining fashion, drawing links from Volkswagens to Bartók to Woody Guthrie, from Swinburne to Seinfeld, Fox traces our ongoing struggle to maintain open societies in the face of profoundly tribal human needs—needs which, paradoxically, hold the key to our survival.

This book covers circadian rhythmicity; analyses of the behavioural and ecological importance of rhythms and their theoretical bases; the comparative anatomy, physiology, genetics and molecular biology of organisms within circadian clocks; real-world examples; classic research and 6 cutting-edge research areas.

The great Paracelsian scholar Walter Pagel and the pioneer medical historian Kurt Polycarp Sprengel identified Petrus Severinus' Idea Medicinæ (1571) as an influential vehicle for the elaboration and diffusion of Paracelsian ideas in the late sixteenth and early seventeenth centuries, a process that has recently come under renewed scrutiny. Severinus' conception that diseases grow from living, seed-like entities proved to be an especially important idea, which was recognized by prominent scientific and medical authors from Oswald Croll and Daniel Sennert to Pierre Gassendi and Robert Boyle. But they also formed a useful theoretical model for reconciling ideas about physical causation with certain Christian Platonist concerns in Protestant theology. A Philosophical Path for Paracelsian Medicine is the first book-length monograph to treat Severinus, a Danish royal physician and contemporary of the great astronomer Tycho Brahe, and to present his ideas in their historical context as well as considering their ramifications for medical and religious theory in the decades prior to the Thirty Years' War. This book will prove to be a useful tool in the reexamination of the process by which Paracelsian ideas were spread and assimilated and will appeal to all those interested the intellectual background for the work of Tycho Brahe and his students and the role of Paracelsian and Hermetic metaphysical ideas in the scientific revolution of the seventeenth century.