Analytical Characterization Of Biotherapeutics
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Analytical Characterization of Biotherapeutics
Author | : Jennie R. Lill,Wendy Sandoval |
Publsiher | : John Wiley & Sons |
Total Pages | : 378 |
Release | : 2017-08-14 |
Genre | : Science |
ISBN | : 9781119053101 |
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The definitive guide to the myriad analytical techniques available to scientists involved in biotherapeutics research Analytical Characterization of Biotherapeutics covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for increasingly complex molecular designs, the book explores the history of the analysis techniques and offers valuable insights into the most important emerging analytical solutions. In addition, it frames critical questions warranting attention in the design and delivery of a therapeutic protein, exposes analytical challenges that may occur when characterizing these molecules, and presents a number of tested solutions. The first single-volume guide of its kind, Analytical Characterization of Biotherapeutics brings together contributions from scientists at the leading edge of biotherapeutics research and manufacturing. Key topics covered in-depth include the structural characterization of recombinant proteins and antibodies, antibody de novo sequencing, characterization of antibody drug conjugates, characterization of bi-specific or other hybrid molecules, characterization of manufacturing host-cell contaminant proteins, analytical tools for biologics molecular assessment, and more. Each chapter is written by a recognized expert or experts in their field who discuss current and cutting edge approaches to fully characterizing biotherapeutic proteins and antigen reagents Covers the full range of characterization strategies for large molecule based therapeutics Provides an up-to-date account of the latest approaches used for large molecule characterization Chapters cover the background needed to understand the challenges at hand, solutions to characterize these large molecules, and a summary of emerging options for analytical characterization Analytical Characterization of Biotherapeutics is an up-to-date resource for analytical scientists, biologists, and mass spectrometrists involved in the analysis of biomolecules, as well as scientists employed in the pharmaceuticals and biotechnology industries. Graduate students in biology and analytical science, and their instructors will find it to be fascinating and instructive supplementary reading.
Approaches to the Purification Analysis and Characterization of Antibody Based Therapeutics
Author | : Allan Matte |
Publsiher | : Elsevier |
Total Pages | : 222 |
Release | : 2020-09-07 |
Genre | : Business & Economics |
ISBN | : 9780081030196 |
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Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book. Covers the vital new area of R&D on therapeutic antibodies Written by leading scientists and researchers Up-to-date coverage and includes a detailed bibliography
Characterization of Protein Therapeutics using Mass Spectrometry
Author | : Guodong Chen |
Publsiher | : Springer Science & Business Media |
Total Pages | : 404 |
Release | : 2014-07-08 |
Genre | : Science |
ISBN | : 9781441978622 |
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This book highlights current approaches and future trends in the use of mass spectrometry to characterize protein therapies. As one of the most frequently utilized analytical techniques in pharmaceutical research and development, mass spectrometry has been widely used in the characterization of protein therapeutics due to its analytical sensitivity, selectivity, and specificity. This book begins with an overview of mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies, quantitative approaches, followed by studies involving characterization of process related protein drug impurities/degradants, metabolites, higher order structures of protein therapeutics. Both general practitioners in pharmaceutical research and specialists in analytical sciences will benefit from this book that details step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development.
Protein Analysis using Mass Spectrometry
Author | : Mike S. Lee,Qin C. Ji |
Publsiher | : John Wiley & Sons |
Total Pages | : 288 |
Release | : 2017-05-26 |
Genre | : Science |
ISBN | : 9781119359364 |
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Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs , instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives Brings together the most current advances in the mass spectrometry technology and related method in protein analysis
State Of the Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization Volume 2 Biopharmaceutical Characterization
Author | : John E. Schiel,Darryl L. Davis,Oleg V. Borisov,Oleg Borisov |
Publsiher | : ACS Symposium |
Total Pages | : 0 |
Release | : 2016-06-24 |
Genre | : Medical |
ISBN | : 0841230293 |
Download State Of the Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization Volume 2 Biopharmaceutical Characterization Book in PDF, Epub and Kindle
"Distributed in print by Oxford University Press."
Characterization of Biotherapeutic Products
Author | : Anurag S. Rathore,Christopher Mark Smales,Andras Guttman |
Publsiher | : Frontiers Media SA |
Total Pages | : 129 |
Release | : 2022-11-10 |
Genre | : Science |
ISBN | : 9782832504758 |
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Characterization of Protein Therapeutics using Mass Spectrometry
Author | : Guodong Chen |
Publsiher | : Springer |
Total Pages | : 0 |
Release | : 2015-06-06 |
Genre | : Science |
ISBN | : 1489973648 |
Download Characterization of Protein Therapeutics using Mass Spectrometry Book in PDF, Epub and Kindle
This book highlights current approaches and future trends in the use of mass spectrometry to characterize protein therapies. As one of the most frequently utilized analytical techniques in pharmaceutical research and development, mass spectrometry has been widely used in the characterization of protein therapeutics due to its analytical sensitivity, selectivity, and specificity. This book begins with an overview of mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies, quantitative approaches, followed by studies involving characterization of process related protein drug impurities/degradants, metabolites, higher order structures of protein therapeutics. Both general practitioners in pharmaceutical research and specialists in analytical sciences will benefit from this book that details step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development.
Protein Analysis using Mass Spectrometry
Author | : Mike S. Lee,Qin C. Ji |
Publsiher | : John Wiley & Sons |
Total Pages | : 290 |
Release | : 2017-06-19 |
Genre | : Science |
ISBN | : 9781118605196 |
Download Protein Analysis using Mass Spectrometry Book in PDF, Epub and Kindle
Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs , instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives Brings together the most current advances in the mass spectrometry technology and related method in protein analysis