Anesthetic Induced Neurotoxicity And Neurocognitive Impairment Of Vulnerable Brains

A practical guide to perioperative cognitive disorders, the most common complications of anesthesia and surgery in older people.

The book focuses on various detection targets applied in single cell studies, including tumor tissue cells, circulating tumor cells (CTCs), disseminated tumor cells (DTCs), circulating tumor DNA (ctDNA), cell-free DNA (cfDNA) and cancer stem cells (CSCs). It also discusses and compares detection methods using these detection targets in different fields to reveal single cell biomedical functions. The volume focuses not only on the methods already been established and validated, and also the methods newly developed. The book also highlights the importance and potential of single cell biomedicine in the development and validation of precision medicine strategies. It is useful for researchers and students in the field of cell biology, molecular medicine and precision medicine etc.

The evolution of cardiothoracic surgery over the last 50 years has allowed increasingly elderly and debilitated patients to benefit from cardiothoracic surgical procedures, with the improved quality and often quantity of life that they provide. The new challenge for the cardiothoracic anesthesiologist is to identify risk of organ dysfunction and provide optimal therapy to prevent it. This latest addition to the Society of Cardiovascular Anesthesiologists Monograph series is focused on perioperative organ protection, outlining the importance of the individual organ system dysfunction, predicting an individual's risk of dysfunction, and recommending strategies or therapies to reduce organ injury and improve long-term outcome.

The clinical practice of anesthesia has undergone many advances in the past few years, making this the perfect time for a new state-of-the-art anesthesia textbook for practitioners and trainees. The goal of this book is to provide a modern, clinically focused textbook giving rapid access to comprehensive, succinct knowledge from experts in the field. All clinical topics of relevance to anesthesiology are organized into 29 sections consisting of more than 180 chapters. The print version contains 166 chapters that cover all of the essential clinical topics, while an additional 17 chapters on subjects of interest to the more advanced practitioner can be freely accessed at www.cambridge.org/vacanti. Newer techniques such as ultrasound nerve blocks, robotic surgery and transesophageal echocardiography are included, and numerous illustrations and tables assist the reader in rapidly assimilating key information. This authoritative text is edited by distinguished Harvard Medical School faculty, with contributors from many of the leading academic anesthesiology departments in the United States and an introduction from Dr S. R. Mallampati. This book is your essential companion when preparing for board review and recertification exams and in your daily clinical practice.

This comprehensive, evidence-based book is intended to serve as a reference for medical practitioners involved in the perioperative care of neurosurgical patients. Fundamental aspects of neuroanesthesiology and neurocritical care are thoroughly examined across 101 chapters, outlining key elements that are crucial to a care provider’s knowledge of the practice. These elements include specific diagnostic procedures and treatment options, concepts and applicable details of the available neurosurgical interventions and techniques, and mechanisms necessary to provide top of the line care for patients. Each chapter features definitive and distinct areas of this multi-specialty discipline, and is designed to guide the reader from problem to solution in situations that can arise in the clinical setting. Essentials of Neurosurgical Anesthesia & Critical Care, 2nd edition is a problem-oriented approach textbook that will aid a wide variety of readers in handling day-to-day issues and developments relevant to the perioperative care of neurosurgical patients.

Since publication of the first edition in 2015, neonatal anesthesia and surgery have advanced at lightning speed with many new developments, hence the need to update several essential topics. These include our understanding of neonatal apoptosis, the ever-increasing use of regional anesthesia in neonates, pharmacology of drugs in neonates, the delivery of anesthesia outside the operating room, neonatal resuscitation/guidelines, and perinatal complexities such as the EXIT procedure together with the fundamental principles of developmental physiology, airway management and ventilation as well as perioperative complications and ethical considerations that are unique to this age group. This comprehensive and well-illustrated book is led by Dr. Jerrold Lerman who brings four decades of research, publication and clinical experience in pediatric and neonatal anesthesia. He has amassed a team of recognized international experts in neonatal anesthesia, surgery, and intensive care to share their knowledge in managing neonates for the challenges they face both within and without the surgical suites. Neonatal Anesthesia, the 2nd edition, is the quintessential clinical reference for perioperative care of these small patients that should be read by trainees as well as experienced clinicians and is certain to become an invaluable resource for every anesthetic and critical care department that serves children. Reviews from the 1st edition: “Lerman’s book stands alone as an up-to-date text dedicated exclusively to the practice of anesthesia in neonates ... . The text covers its subject matter in extraordinary breadth and depth. ... Throughout the book there are illustrative and clinically relevant diagrams, nicely supporting and summarizing relevant text for the more visual learner. ... Neonatal Anesthesia is a sophisticated but approachable text that offers its readers theory-based practical approaches to understanding and managing anesthesia in our youngest, most fragile patient population.” (Stephanie A. Black and Lynne G. Maxwell, Anesthesiology, Vol. 125 (3), 2016) “It is a long-awaited contribution to the literature, filling a gap of over a decade without a neonatal anaesthesia textbook. ... textbook should hold an essential and required spot on the bookshelf of any anaesthetist or critical care physician who cares for neonates. ... The reference lists are comprehensive and exhaustive. Dr Lerman should be commended for finally presenting the anaesthesia community worldwide with this textbook, which will be able to stand on its own, probably for the next decade.” (K. P. Mason, British Journal of Anaesthesia, Vol. 116 (4), 2016) “This book covers in 400-plus pages and 17 chapters most of what is known about the neonatal airway, physiology, drugs and anesthetics, with separate chapters on each subcategory of neonatal anesthesia. ... Certainly pediatric surgeons, anesthesiologists who only occasionally care for children, students, residents, and fellows will appreciate this book. ... This is a large book on a narrow topic that has increasing relevance to the field of current pediatric practice. It is well written, well illustrated, and highly useful.” (Robert M. Arensman, Doody’s Book Reviews, April, 2015) “The book has many outstanding chapters that have been thoughtfully crafted by leading researchers in specific fields. ... this book is an essential addition to any pediatric anesthesiology library in any organization that provides care to neonates. This book is an excellent resource, not only for anesthesiologists at every level of training and expertise but also for other professionals who provide postoperative care, administer sedative drugs, control the airway, and undertake procedures in newborn infants.” (Carolyne Montgomery and J. Mark Ansermino, Canadian Journal of Anesthesia, Vol. 62, 2015)

In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.