Animal Clinical Chemistry

By presenting background information on the selection and application of biochemical tests in safety assessment studies, this text seeks to provide a basis for improving the knowledge required to interpret data from toxicological studies. In addition to chapters which discuss the assessment of specific organ toxicity (such as the liver, kidney and thyroid), the book also covers pre-analytical variables, regulatory requirements and statistical approaches, and highlights some of the major differences between man and different laboratory animals. The editor and contributor are all members of the Animal Clinical Chemistry Association, a group formed to advance the science of animal clinical chemistry in safety evaluation, toxicology and veterinary science.

This title provides veterinary students and non-specialist with a case study base workbook which serves as a guide to effective use and interpretation of clinical chemistry laboratory methods in domestic animals. There are over 100 case studies involving real patients and findings in dogs, cats, horses, lamas, alpacas, pot belled pigs and ferrets. Case studies consist of patient history, physical examination findings, and clinicopthologic data such as CBC, urinalysis, cytology or fluid analysis. A summary is given for each patient that includes a description of follow up tests and response to treatment. Multiple cases of common diseases are included to illustrate the variety of clinciopathologic findings with the same diagnosis depending on individual patient factors. Diagnostic dilemmas in which different diseases may present with similar clinical signs and laboratory data are also included. Published by Teton New Media in the USA and distributed by Manson Publishing outside of North America.

Key features: Serves as the detailed, authoritative source of the clinical chemistry of the most commonly used laboratory animals Includes detailed chapters dedicated to descriptions of clinical chemistry-related topics specific to each laboratory species as well as organ/class-specific chapters Presents information regarding evaluation and interpretation of a variety of individual clinical chemistry end points Concludes with detailed chapters dedicated to descriptions of statistical analyses and biomarker development of clinical chemistry-related topics Provides extensive reference lists at the end of each chapter to facilitate further study Extensively updated and expanded since the publication of Walter F. Loeb and Fred W. Quimby’s second edition in 1999, the new The Clinical Chemistry of Laboratory Animals, Third Edition continues as the most comprehensive reference on in vivo animal studies. By organizing the book into species- and organ/class-specific chapters, this book provides information to enable a conceptual understanding of clinical chemistry across laboratory species as well as information on evaluation and interpretation of clinical chemistry data relevant to specific organ systems. Now sponsored by the American College of Laboratory Animal Medicine (ACLAM), this well-respected resource includes chapters on multiple laboratory species and provides pertinent information on their unique physiological characteristics, methods for sample collection, and preanalytical sources of variation for the particular species. Basic methodology for common procedures for each species is also discussed. New Chapters in the Third Edition Include: The Laboratory Zebrafish and Other Fishes Evaluation of Cardiovascular and Pulmonary Function and Injury Evaluation of Skeletal Muscle Function and Injury Evaluation of Bone Function and Injury Vitamins Development of Biomarkers Statistical Methods The Clinical Chemistry of Laboratory Animals, Third Edition is intended as a reference for use by veterinary students, clinical veterinarians, verterinary toxicologists, veterinary clinical pathologists, and laboratory animal veterinarians to aid in study design, collection of samples, and interpretation of clinical chemistry data for laboratory species.

By presenting background information on the selection and application of biochemical tests in safety assessment studies, this text seeks to provide a basis for improving the knowledge required to interpret data from toxicological studies. In addition to chapters which discuss the assessment of specific organ toxicity (such as the liver, kidney and

This guide provides an easy-to-use desk reference for diagnostic information on commonly used hematology, clinical chemistry and urinalysis parameters. Additional reference materials are provided as an aid in evaluating clinical pathology data. For many toxicologists, the evaluation of hematology, clinical chemistry and urinalysis data can be the most challenging aspect of animal toxicity studies. In a typical toxicity study, dozens of parameters are measured several times over the course of the study. There may be hundreds of data points, each of which needs to be considered. A Toxicologist’s Guide to Clinical Pathology in Animals will serve as an essential primer for toxicologists in training and in industry as well as for researchers and professionals in a veterinary practice or a laboratory.

This case study based workbook provides veterinary students and non-specialist with a guide to effective use and interpretation of clinical chemistry laboratory methods in domestic animals. The 100+ case studies involve real patients and findings in dogs, cats, horses, lamas, alpacas, pot belled pigs and ferrets. These consist of patient history, physical examination findings, and clinicopthologic data such as CBC, urinalysis, cytology or fluid analysis. A summary is given for each patient that includes a description of follow up tests and response to treatment. Multiple cases of common diseases illustrate the variety of clinciopathologic findings with the same diagnosis depending on individual patient factors. Diagnostic dilemmas in which different diseases may present with similar clinical signs and laboratory data are also included. Published by Teton New Media in the USA and distributed by CRC Press outside of North America.

Clinical Biochemistry of Domestic Animals, Second Edition, Volume I, is a major revision of the first edition prompted by the marked expansion of knowledge in the clinical biochemistry of animals. In keeping with this expansion of knowledge, this edition is comprised of two volumes. Chapters on the pancreas, thyroid, and pituitary-adrenal systems have been separated and entirely rewritten. Completely new chapters on muscle metabolism, iron metabolism, blood clotting, and gastrointestinal function have been added. All the chapters of the first edition have been revised with pertinent new information, and many have been completely rewritten. This volume contains 10 chapters and opens with a discussion of carbohydrate metabolism and associated disorders. Separate chapters follow on lipid metabolism, plasma proteins, and porphyrins. Subsequent chapters deal with liver, pancreatic, and thyroid functions; the role of the pituitary and adrenal glands in health and disease; the function of calcium, inorganic phosphorus, and magnesium metabolism in health and disease; and iron metabolism.

A quick guide to appropriately selecting and interpreting laboratory tests, Small Animal Clinical Diagnosis by Laboratory Methods, 5th Edition helps you utilize your in-house lab or your specialty reference lab to efficiently make accurate diagnoses without running a plethora of unnecessary and low-yield tests. It provides answers to commonly asked questions relating to laboratory tests, and solutions to frequently encountered problems in small animal diagnosis. For easy reference, information is provided by clinical presentation and abnormalities, and includes hundreds of tables, boxes, key points, and algorithms. This edition, now in full color, is updated with the latest advances in laboratory testing methods and diagnostic problem solving. Written by noted educators Dr. Michael Willard and Dr. Harold Tvedten, this book may be used as an on-the-spot guide to specific problems or conditions as well as a reference for more detailed research on difficult cases. Concise discussions address laboratory approaches to various disorders, possible conclusions from various test results, artifacts and errors in diagnoses, and interpretations leading to various diagnoses. Hundreds of tables, boxes, algorithms, and key points offer at-a-glance information including cautions, common pitfalls, and helpful "pearls," and lead to proper differential and clinical diagnostic decision making. Note boxes identify key considerations in correlating clinical signs with test data for accurate diagnoses, highlight safety precautions, and offer helpful tips for sample preparation and interpretation. Chapters on laboratory diagnostic toxicology and therapeutic drug monitoring help in handling potentially fatal poisonings and other special situations. Expert editors and contributors provide clinical knowledge and successful diagnostic problem-solving solutions. A practical appendix lists referral laboratories that may be contacted for certain diseases, and reference values with the normal or expected range for coagulation, hematology, and more. Updated coverage integrates the newest advances in testing methods and diagnostic problem solving. Full-color photos and schematic drawings are placed adjacent to related text, and accurately depict diagnostic features on microscopic slide preparations as well as test procedures and techniques.