Applications Of Nanotechnology In Drug Discovery And Delivery

Applications of Nanotechnology in Drug Discovery and Delivery, in the Drug Discovery Update series, presents complete coverage of the application of nanotechnology in the discovery of new drugs and efficient target delivery of drugs. The book highlights recent advances of nanotechnology applications in the biomedical sciences, starting with chapters that provide the basics of nanotechnology, nanoparticles and nanocarriers. Part II deals with the application of nanotechnology in drug discovery, with an emphasis on enhanced delivery of pharmaceutical products, with Part III discussing toxicological and safety issues arising from the use of nanomaterials. This book brings together a global team of experts, making it an essential resource for researchers, drug developers, medicinal chemists, toxicologists and analytical chemists. Serves as a guide to drug developers working in pharma, biotech and academia, bringing together the latest research on the topic Presents recent information on the use of nanomaterials for the development of drugs using engineered nanocarriers to target specific delivery Features a global team of contributing experts who discuss nanotechnology applications in drug discovery as well as safety issues and challenges

This book collects reviews and original articles from eminent experts working in the interdisciplinary arena of nanotechnology use in drug delivery. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of nanotechnology application of drug delivery. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

This important new book provides the fundamental understanding of the peptide and protein drug delivery systems with a special focus on their nanotechnology applications. Addressing an increasing interest in peptide and protein drug delivery systems in both academic and industrial circles worldwide, this book fills the need for a comprehensive review and assessment of conventional and nonconventional routes of administration.

Applications of nanotechnology are the remarkable sizes dependent on physiochemical properties of nanomaterials that have led to the developed protocols for synthesizing nanomaterials over a range of size, shapes and chemical compositions. Nanomaterials are normally powders composed of nanoparticles which exhibit properties that are different from powders. Nanotechnology is the engineering of functional systems at the molecular scale with their wide applications in energy sector, including -but not limited to- energy resources, energy conversion, energy storage, and energy usage; drug delivery systems including- safety concerns, perspective, challenges, target therapeutics for cancer, neurodegenerative diseases and other human diseases, nanomaterials based tissue engineering; and food sectors including to- food safety and quality, opportunities, challenges, nanomaterials based enhancing food packing, and determination of foodborne pathogens, agro and marine food, analysis of market, regulations and future prospects. The utilization of nanotechnology in the energy field will be emphasized and highlighted, in accordance to their prominent and high impact in this particular field. Recent trends and significant benefits of nanotechnology in the energy field will be revealed to the readers, and their promising advanced applications will be discussed. The current drug discovery paradigm constantly needs to improve, enhance efficiency and reduce time to the market on the basis of designing new drug discovery, drug delivery and pharmaceutical manufacturing. In this book will be highlighted nanotechnology based drug delivery is an important aspect of medicine, as more potent and specific drugs that are particularly discussed the understanding of disease pathways. Several biomaterials can be applied to small-molecule drugs as controlled release reservoirs for drug delivery and provide new insights into disease processes, thus understanding the mechanisms of action of drugs. Applications of food nanotechnology are an area of emerging interest for the food industry, for the reason, in this book will be given more priority to discuss the uses of nanomaterials for food packing, food safety and quality, and to remove the contaminated or spoiled by foodborne pathogens. And also nanotechnology based food products will be discussed how making them tastier, healthier, and more nutritious such as vitamins, to reduce fat content, and to ensure they do not degrade during a product’s shelf life. Nanotechnology is basically the uses of nanomaterials, devices and systems through the control of matter on the nanometer scale. Multidisciplinary studies are required the technology for discovery and moving so fast from concept to the reality. Nanotechnology always not only provided more benefits in energy, drugs and food products but also provided significantly benefits around multidisciplinary field applications.

Applications of Targeted Nano-Drugs and Delivery Systems: Nanoscience and Nanotechnology in Drug Delivery explores the applications of Nano-drugs and their delivery systems, investigating the role they can play in key body systems and major diseases. The book explores how nanotechnology can be deployed in developing new drug delivery systems and how they enable pharmaceutical companies to reformulate existing drugs on the market, thereby extending the lifetime of products and enhancing performance by increasing effectiveness, safety and patient adherence, and ultimately reducing healthcare cost. Reflecting the interdisciplinary nature of the subject matter, this book includes contributions by experts from different fields. Readers will find a reference and practical source of guidance for researchers, students and scientists working in the fields of nanotechnology, materials science, and technology and biomedical science. Enables readers from different fields to access recent research and protocols across traditional boundaries Focuses on protocols and techniques, as well as the knowledge base of the field, thus enabling those in R&D to learn about, and successfully deploy, cutting-edge techniques Explores the applications of Nano-drugs and their delivery systems, investigating the role they can play in key body systems and major disease types

Advances in Nanotechnology-Based Drug Delivery Systems covers the core concepts and latest research regarding the use of nanoscale materials for the development and application of drug delivery systems. The book introduces the reader to nanotechnology in drug delivery, covering the synthesis, encapsulation techniques, characterization and key properties of nanoscale drug delivery systems. Later chapters review the broad range of target applications, including site-specific delivery of drugs for cardiovascular disease, cancer, bacterial infection, bone regeneration. and much more. This book helps translate advanced research into a clinical setting, analyzing the toxicity and health and safety challenges associated with utilizing nanotechnology in biomedicine. This will be a useful reference for those interested in nano-sized drug delivery in biomedicine, including academics and researchers in materials science, biomedical engineering, pharmaceutical science and related disciplines. Provides a clear introduction to nanotechnology in drug delivery, covering key principles, synthesis, characterization and unique properties of nanoscale materials for drug delivery systems“/li> Discusses preclinical, clinical and patented nano-drug delivery systems, enabling the reader to grasp the current state-of-the-art and market Covers a broad range of targets for nanoscale drug delivery systems, such as in neurological disorders, oral disease, renal disease, cancer, skin protection, and much more

This book will provide an overview of the chemistry of nanocarrier design and the considerations that need to be made when developing a nanomedicine.

Continuing improvement in the pharmacological and therapeutic properties of drugs is driving the revolution in novel drug delivery systems. In fact, a wide spectrum of therapeutic nanocarriers has been extensively investigated to address this emerging need. Nanotechnology involves the engineering of functional systems at the molecular scale. Recent years have witnessed unprecedented growth of research and applications in the area of nanoscience and nanotechnology. There is increasing optimism that nanotechnology, as applied to medicine, will bring significant advances in the diagnosis and treatment of disease. Anticipated applications in medicine include drug delivery, both in vitro and in vivo diagnostics, nutraceuticals and production of improved biocompatible materials. As such, nanomaterials are poised to take advantage of existing cellular machinery to facilitate the delivery of drugs. The use of nanotechnology in medicine and more specifically drug delivery is set to spread rapidly. Currently many substances are under investigation for drug delivery and more specifically for cancer therapy. anoparticles (NPs) containing encapsulated, dispersed, absorbed or conjugated drugs have unique characteristics that can lead to enhanced performance in a variety of dosage forms. When formulated correctly, drug particles are resistant to settling and can have higher saturation solubility, rapid dissolution and enhanced adhesion to biological surfaces, thereby providing rapid onset of therapeutic action and improved bioavailability. In addition, the vast majority of molecules in a nanostructure reside at the particle surface, which maximizes the loading and delivery of cargos, such as therapeutic drugs, proteins and polynucleotides, to targeted cells and tissues. Highly efficient drug delivery, based on nanomaterials, could potentially reduce the drug dose needed to achieve therapeutic benefit, which, in turn, would lower the cost and/or reduce the side effects associated with particular drugs. This book, Application of Nanotechnology in Drug Delivery, deals with the new and ongoing potentialities of nanotechnology application of drug delivery. In addition, it discusses advances in design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.