Basic Principles Of Cancer Chemotherapy

This book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer, which includes Surgery, Radiation therapy, Chemotherapy, Targeted therapy and Immunotherapy. The efficiency of all these treatments is limited by the capacity of cancer cells to escape therapy. This book explains the mechanisms of anti-cancer drug resistance and strategies to overcome it. The discovery and development process of a new drug is detailed beginning with the identification and validation of a therapeutic target, the identification of an inhibitor of the target and its subsequent preclinical and clinical development until its approval by regulatory authorities. Particular emphasis has been given to specific aspects of the development process including lead generation and optimization, pharmacokinetics, ADME analysis, pharmacodynamics, toxicity and efficacy assessment, investigational new drug (IND) and new drug application (NDA) and the design of clinical trial and their phases. The book covers many aspects of modern personalized oncology and discusses economic aspects of our current system of developing new medicines and its impact on our societies and on future drug research. The author of this book, Dr. Link counts with more than 20 years of experience in biomedical research reflected in numerous publications, patents and key note and plenary presentations at international conferences. Interested readers, students and teachers should read this book as it provides a unique way to learn/teach about basic concepts in oncology and anti-cancer drug research.

The Sixth Edition of this handbook is a practical, disease-focused pocket reference that emphasizes the optimal current medical practice as it relates to the delivery of chemotherapeutic drugs. In an easy-to-follow outline format, the book provides complete coverage of the basic principles of rational chemotherapy, the drugs and biologic agents available, the treatment of specific cancers, and selected aspects of supportive care. New to this edition: advances in therapies for individual cancers; significant updating of the drug information section and specific tumor types to reflect the recent development of many new agents, particularly biologic ones; and new American Cancer Society screening guidelines and cancer website information.

Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.

Includes free CD-ROM! Completely revised and updated for 2007, this practical handbook is an up-to-date guide to all aspects of cancer chemotherapy. The book provides a comprehensive, easy to use catalogue of over 100 drugs-both on- and off-label-commonly used in cancer treatment, including several new agents (recently or about to be FDA approved). A section on Common Chemotherapy Regimens provides a quick reference to management of specific cancers, arranged alphabetically. A comprehensively revised introductory chapter on Principles of Chemotherapy offers a concise, current overview of the field. Special features include: Special chapter profiling anti-emetic drugs Diagrams of drug structures and pathways Complete discussion of clinical pharmacology, indications, and dosages Coverage of toxicity and interactions Separate chapter on chemotherapy regimens for specific cancers Overview of basic principles of cancer drug therapy Easy to load and use CD-ROM version PDA version of Physicians' Cancer Chemotherapy Drug Manual also available!

This book provides the practising GP with all the information needed to help in the management of patients with cancer.

This book is intended as an introduction to the drug treatment of cancer. It is almost ten years since the last edition was written. In the intervening time, there have been numerous developments in cancer chemotherapy and in order to cover these the majority of the text has been completely revised and rewritten. In addition, two new chapters have been introduced, one on the safe handling of cytotoxic drugs and the other on biological response modifiers. In order to incorporate this new information without any undue increase in the length of the text the chapters on a combined approach to treatment have been omitted. This is not because interdisciplinary collaboration is no longer considered important but is a reflection of the fact that, in most centres, it has become the norm in cancer management and its central role in successful treatment no longer needs to be stressed quite so strongly. The four chapters in the last edition which dealt with the team approach to cancer therapy have been replaced by a single chapter on the place of chemotherapy in the overall treatment of cancer. Unfortunately, despite all the innovations of the last decade, it has become increasingly clear that much of the promise offered by drug treatment during the 1960s and 1970s has not been fulfilled.