Bio Inspired Regenerative Medicine

This book presents a wide and interdisciplinary overview of the current state of the art in the development of biomimetic materials for tissue regeneration on the basis of relevant and high-impact clinical needs. It specifically emphasizes the regeneration of bone, cartilage, and osteochondral tissues as well as soft tissues such as nerves, heart, and endocrine organs. It brings together contributions from materials scientists, biologists, and surgeons with globally recognized experience in the field of regenerative medicine. The aim of the book is to highlight the relevance of biomimetics as an elective approach for the development of new scaffolds that can direct regenerative cascade by means of chemico-physical and topological nano-cues presented to cells and biologic tissues. Particularly, the book refers to emerging concepts in synthesis processes and scaffolds inspired by nature as well as to novel approaches for smart functionalization such as the use of magnetic signaling.

This book covers the latest bio-inspired materials synthesis techniques and biomedical applications that are advancing the field of tissue engineering. Bio-inspired concepts for biomedical engineering are at the forefront of tissue engineering and regenerative medicine. Scientists, engineers and physicians are working together to replicate the sophisticated hierarchical organization and adaptability found in nature and selected by evolution to recapitulate the cellular microenvironment. This book demonstrates the dramatic clinical breakthroughs that have been made in engineering all four of the major tissue types and modulating the immune system. Part I (Engineering Bio-inspired Material Microenvironments) covers Bio-inspired Presentation of Chemical Cues, Bio-inspired Presentation of Physical Cues, and Bio-inspired Integration of Natural Materials. Part II (Bio-inspired Tissue Engineering) addresses tissue engineering in epithelial tissue, muscle tissue, connective tissue, and the immune system.

Bioinspired Materials for Medical Applications examines the inspiration of natural materials and their interpretation as modern biomaterials. With a strong focus on therapeutic and diagnostic applications, the book also examines the development and manipulation of bioinspired materials in regenerative medicine. The first set of chapters is heavily focused on bioinspired solutions for the delivery of drugs and therapeutics that also offer information on the fundamentals of these materials. Chapters in part two concentrate on bioinspired materials for diagnosis applications with a wide coverage of sensor and imaging systems With a broad coverage of the applications of bioinspired biomaterials, this book is a valuable resource for biomaterials researchers, clinicians, and scientists in academia and industry, and all those who wish to broaden their knowledge in the allied field. Explores how materials designed and produced with inspiration from nature can be used to enhance man-made biomaterials and medical devices Brings together the two fields of biomaterials and bioinspired materials Written by a world-class team of research scientists, engineers, and clinicians

Regeneration of tissues and organs remains one of the great challenges of clinical medicine, and physicians are constantly seeking better methods for tissue repair and replacement. Tissue engineering and regenerative medicine have been investigated for virtually every organ system in the human body, and progress is made possible by advances in materials science, polymer chemistry, and molecular biology. This book reviews the current status of biomaterials for regenerative medicine, and highlights advances in both basic science and clinical practice. The latest methods for regulating the biological and chemical composition of biomaterials are described, together with techniques for modulating mechanical properties of engineered constructs. Contributors delineate methods for guiding the host response to implantable materials, and explain the use of biologically-inspired materials for optimal biological functionality and compatibility. The book culminates in a discussion of the clinical applications of regenerative medicine. By integrating engineering and clinical medicine, Engineering Biomaterials for Regenerative Medicine examines how tissue engineering and regenerative medicine can be translated into successful therapies to bridge the gap between laboratory and clinic. The book will aid materials scientists and engineers in identifying research priorities to fulfill clinical needs, and will also enable physicians to understand novel biomaterials that are emerging in the clinic. This integrated approach also gives engineering students a sense of the excitement and relevance of materials science in the development of novel therapeutic strategies.

This book explores in depth a wide range of new biomaterials that hold great promise for applications in regenerative medicine. The opening two sections are devoted to biomaterials designed to direct stem cell fate and regulate signaling pathways. Diverse novel functional biomaterials, including injectable nanocomposite hydrogels, electrosprayed nanoparticles, and waterborne polyurethane-based materials, are then discussed. The fourth section focuses on inorganic biomaterials, such as nanobioceramics, hydroxyapatite, and titanium dioxide. Finally, up-to-date information is provided on a wide range of smart natural biomaterials, ranging from silk fibroin-based scaffolds and collagen type I to chitosan, mussel-inspired biomaterials, and natural polymeric scaffolds. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth the latest enabling technologies for regenerative medicine.

Regenerative medicine is the main field of groundbreaking medical development and therapy using knowledge from developmental and stem cell biology as well as advanced molecular and cellular techniques. This collection of volumes, Regenerative Medicine: From Protocol to Patient, aims to explain the scientific knowledge and emerging technology as well as the clinical application in different organ systems and diseases. International leading experts from all over the world describe the latest scientific and clinical knowledge of the field of regenerative medicine. The process of translating science of laboratory protocols into therapies is explained in sections on regulatory, ethical and industrial issues. The collection is organized into five volumes: (1) Biology of Tissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering, Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) Regenerative Therapies II. The textbook gives the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientific basis, therapeutical protocols, clinical translation and practiced therapies in regenerative medicine. Volume 3: Tissue engineering, Biomaterials and Nanotechnology focuses the development of technologies, which enable an efficient transfer of therapeutic genes and drugs exclusively to target cells and potential bioactive materials for clinical use. Principles of tissue engineering, vector technology, multifunctionalized nanoparticles, biodegradable materials, controlled release, and biointerface technology are described with regard to the development of new clinical cell technology. Imaging and targeting technologies as well as biological aspects of tissue and organ engineering are depicted.

Principles of Regenerative Medicine, Third Edition, details the technologies and advances applied in recent years to strategies for healing and generating tissue. Contributions from a stellar cast of researchers cover the biological and molecular basis of regenerative medicine, highlighting stem cells, wound healing and cell and tissue development. Advances in cell and tissue therapy, including replacement of tissues and organs damaged by disease and previously untreatable conditions, such as diabetes, heart disease, liver disease and renal failure are also incorporated to provide a view to the future and framework for additional studies. Comprehensively covers the interdisciplinary field of regenerative medicine with contributions from leaders in tissue engineering, cell and developmental biology, biomaterials sciences, nanotechnology, physics, chemistry, bioengineering and surgery Includes new chapters devoted to iPS cells and other alternative sources for generating stem cells as written by the scientists who made the breakthroughs Edited by a world-renowned team to present a complete story of the development and promise of regenerative medicine