Bioactive Materials For Bone Regeneration

Bioactive Materials for Bone Regeneration summarizes research advances on the topic, including sections on the characteristics of biomaterial-induced microenvironments, interactions of bioactive materials with stem cells and tissues, and the immunomodulatory microenvironment induced by biomaterials and its effects on osteogenesis. As the regeneration of large-size bone tissue defects represents a significant clinical challenge, this book demonstrates how new biomaterials with specific chemical and physical characteristics may interact with the host and create a unique micro-environment that actively facilitates stem cell differentiation along a specific lineage, thus stimulating tissue regeneration.

Bioactive Materials for Bone Regeneration summarizes research advances on the topic, including sections on the characteristics of biomaterial-induced microenvironments, interactions of bioactive materials with stem cells and tissues, and the immunomodulatory microenvironment induced by biomaterials and its effects on osteogenesis. As the regeneration of large-size bone tissue defects represents a significant clinical challenge, this book demonstrates how new biomaterials with specific chemical and physical characteristics may interact with the host and create a unique micro-environment that actively facilitates stem cell differentiation along a specific lineage, thus stimulating tissue regeneration. Provides readers with the latest research developments in the fabrication techniques of bioactive materials for tissue regeneration and tissue engineering applications Presents the latest research advancements on how bioactive materials interact with the host and induce micro-environments for stem cell differentiation, immunomodulation and tissue regeneration Covers the methods, strategies, principle and mechanisms on constructing beneficial biomaterial microenvironments

Bioceramics play an important role in repairing and regenerating defective or damaged bone. Annually, more than 500,000 bone graft procedures are performed in the United States and approximately 2.2 million are conducted worldwide. Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery reviews the latest advances in the field of bioceramics. The book summarizes innovative concepts, bioceramic design, and methods for material synthesis and drug delivery. Offering guidance for biomedical engineering researchers and material scientists, the book explores: Novel mesoporous bioactive glasses and silicate-based ceramics for bone regeneration and drug delivery Bioactive silicate ceramics, including their mechanical properties, interaction with bone-forming cells, and in vivo osteogenesis and angiogenesis Silica nanospheres with a core-shell structure and their specific properties for controllable drug delivery The 3D-printing technique to prepare advanced bioceramic scaffolds for bone tissue engineering applications—including the preparation, mechanical strength, and biological properties of 3D-printed porous scaffolds of calcium phosphate cement and silicate bioceramics Biomimetic preparation and controllable crystal growth and biomineralization of bioceramics Inorganic and organic composite materials and their unique biological, electrical, and mechanical properties that enable the design of excellent bone regeneration and gene delivery systems A comprehensive survey of the research progress of bioceramics and their applications in bone repair and regeneration, this volume is designed to enhance study and career development for those in this field and to facilitate further research and opportunities for new solutions.

Bioceramics play an important role in repairing and regenerating defective or damaged bone. Annually, more than 500,000 bone graft procedures are performed in the United States and approximately 2.2 million are conducted worldwide. Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery reviews the latest advances in the field of bioceramics. The book summarizes innovative concepts, bioceramic design, and methods for material synthesis and drug delivery. Offering guidance for biomedical engineering researchers and material scientists, the book explores: Novel mesoporous bioactive glasses and silicate-based ceramics for bone regeneration and drug delivery Bioactive silicate ceramics, including their mechanical properties, interaction with bone-forming cells, and in vivo osteogenesis and angiogenesis Silica nanospheres with a core-shell structure and their specific properties for controllable drug delivery The 3D-printing technique to prepare advanced bioceramic scaffolds for bone tissue engineering applications—including the preparation, mechanical strength, and biological properties of 3D-printed porous scaffolds of calcium phosphate cement and silicate bioceramics Biomimetic preparation and controllable crystal growth and biomineralization of bioceramics Inorganic and organic composite materials and their unique biological, electrical, and mechanical properties that enable the design of excellent bone regeneration and gene delivery systems A comprehensive survey of the research progress of bioceramics and their applications in bone repair and regeneration, this volume is designed to enhance study and career development for those in this field and to facilitate further research and opportunities for new solutions.

Bone Repair Biomaterials: Regeneration and Clinical Applications, Second Edition, provides comprehensive reviews on materials science, engineering principles and recent advances. Sections review the fundamentals of bone repair and regeneration, discuss the science and properties of biomaterials used for bone repair, including metals, ceramics, polymers and composites, and discuss clinical applications and considerations, with chapters on such topics as orthopedic surgery, tissue engineering, implant retrieval, and ethics of bone repair biomaterials. This second edition includes more chapters on relevant biomaterials and a greatly expanded section on clinical applications, including bone repair applications in dental surgery, spinal surgery, and maxilo-facial and skull surgery. In addition, the book features coverage of long-term performance and failure of orthopedic devices. It will be an invaluable resource for researchers, scientists and clinicians concerned with the repair and restoration of bone. Provides a comprehensive review of the materials science, engineering principles and recent advances in this important area Presents new chapters on Surface coating of titanium, using bone repair materials in dental, spinal and maxilo-facial and skull surgery, and advanced manufacturing/3D printing Reviews the fundamentals of bone repair and regeneration, addressing social, economic and clinical challenges Examines the properties of biomaterials used for bone repair, with specific chapters assessing metals, ceramics, polymers and composites

Advanced Techniques in Bone Regeneration is a book that brings together over 15 chapters, written by leading practitioners and researchers, of the latest advances in the area, including surgical techniques, new discoveries, and promising methods involving biomaterials and tissue engineering. This book is intended for all who work in the treatment of disorders involving problems with the regeneration of bone tissue, are doctors or dentists, as well as are researchers and teachers involved in this exciting field of scientific knowledge.

Volume is indexed by Thomson Reuters BCI (WoS). The aim of “Biomaterials for Bone Regenerative Medicine” is to review extensively the latest developments in Biomaterials and their application to bone regeneration in vivo. Indeed, research on biomaterials and their novel applications is essential because of the health issues related to the aging population. A wide range of worldwide investigations is being undertaken by eminent scholars in order to develop further innovative materials for next-generation applications. In future, it is expected that a tissue engineering approach, associating novel biomaterials with stem cells, will be available for all types of bone defect.

Translating Biomaterials for Bone Graft: Bench-top to Clinical Applications brings together the current translational research in bone tissue engineering, from design to application – from materials, drugs and biologic delivery used for bone graft applications to pre-clinical and clinical considerations. The book also discusses the regulatory approval pathways, which involves consideration of the class of devices; whether they are similar to existing solutions, minimal manipulation of donor tissue or completely novel materials, drugs and biologics. These considerations drive the ability to successfully transition the latest generations of bone graft materials into the clinics. Chapters come from materials scientists, clinicians, researchers, and consultants and provide a holistic understanding of the field. As such, the book is a state-of-the-art reference to bone therapies and should appeal to clinicians, scientists, as well as students interested in the current research and/or practices in the field of bone regeneration and restoration.