Bioactive Phytochemicals Drug Discovery To Product Development

Natural bioactive compounds from medicinal plants are inexplicably diverse in chemical structure and biological properties. The unmet therapeutic requirements for various diseases serve as a guide for researchers to study natural compounds. These studies are intended to isolate, identify the structural characterization and eventually discover the pharmacological activity of natural compounds from their plant sources with the goal of treating specific diseases. Bioactive Phytochemicals: Drug Discovery to Product Development explores the scope and approaches of drug discovery from natural products. Chapters in the book cover information about the cultivation, collection and processing of medicinal plants, the methods and high throughput techniques for isolation and characterization of bioactive phytochemicals and pharmacological screening for activity, formulation and quality control. Information about the regulations specified for natural medicinal products in different region of the world is also presented, followed by a concluding chapter devoted to the role of natural herbal products for treatment of human diseases such as cancer, cardiovascular diseases, diabetes, obesity, inflammation and neurological disorders. Each chapter concludes with a general reference section, which is a bibliographic guide to more advanced texts. The contributing authors for this volume are drawn from a rich blend of experts in various areas of herbal medicine which encompass herbal drug discovery to product development. The concise and organized layout along with a broad coverage of phytochemistry and drug discovery makes this book a suitable reference for students of medicinal chemistry, researchers and industry professionals interested in herbal product development.

Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays.

Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. Presents fundamental concepts and factors affecting choice for plant-based products Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward Highlights recent advances in computational-based drug discovery Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance

This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the book’s closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the book’s goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies.

Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays.

A bioactive compound is a type of chemical that can be found in plants and specific foods including nuts, whole grains, fruits, oils and vegetables in small amounts. The actions of bioactive compounds in the body can encourage good health. These compounds are studied in pharmaceutical sciences to treat a variety of medical conditions. Tannins, lycopene, lignan, indoles and resveratrol are few examples of bioactive compounds. Natural products derived from bacteria, marine life, plants, fungi, animals and other organisms are a valuable resource for drug discovery and development. Bioactive natural products have a wide range of biological activities that are beneficial to human health, such as anti-inflammatory, anticancer, antibiotic, biofilm inhibitory effects, antifungal and immunosuppressive properties. Different natural products from both terrestrial and marine organisms have been identified and characterized, as these products have unique chemical structures and noteworthy biological functions. This book aims to understand the role of bioactive natural products in drug discovery. Researchers and students engaged in drug discovery will be assisted by it.

Plant kingdom represents a vast emporium of untapped medicinal potential and play a vital role for the development of new drugs. The medicinal value of drug plants is due to the presence of some chemical compounds in the plant tissue that produce a definite physiological action on human body. Early societies learned through trial and error that many plants contained substances with significant curative properties and over the years the natural products became used in more refined ways leading ultimately to the use of pure single component "active ingredient" as drugs. However, the demands of modern medicine requires the evaluation of these plant bioactives using scientific methodologies and assays in order to gauge their potential in the management of the disease. Therefore, extracts and biomolecules with promising activity are unscrupulously screened for efficacy in order to determine if these products have a potential for commercial development. The present book "Bioactive Phytochemicals: Perspectives for Modern Medicine Vol. 1" presents the vast body of research on the subject and includes fifteen research and review communications written by eminent scientists and researchers from India, Brazil, China, Japan, Maxico, Singapore and South Africa and includes topics like - Bioactive pregnanes and cardenolides from Nerium olander; Chemical characteristics and health promoting potentials of flavonoids in the management of diabetes; Limonene: A systematic overview for its chemistry and bioactivity; Phytochemicals against liver disease I: Recent progress in the treatment of AFLD and NAFLD by natural drug products and their active chemical entities, in China and other countries; Phytochemicals against liver disease II: Recent progress in the treatment of liver fibrosis by natural drug products and their active chemical entities, in China and other countries; Anti-allergic leads from Indian medicinal plant; Essential oils from Brazilian Amazonia; Phytochemical and pharmacological profile of plants belonging to Strychnos genus; Phytochemicals as natural antimicrobials; Biomedical potentials of filamentous marine cyanobacterial natural products; Natural bioactive compound from marine plants with anticancer potential; The lauraceae alkaloids; Phytochemical and pharmacological profile of Lepidium sativum Linn.; Chemistry and pharmacology of selected Asian and American medicinal species of Justicia; Biological activities of Anoectochilus formosanus Hayat and its active component. We hope that this volume shall generate further database and interest for the benefit of academicians, researchers and scientists working on bioactive phytochemicals who shall find the compendium very useful and indispensable in their relevant research pursuits.

Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations.