Biodegradation Of Nitroaromatic Compounds And Explosives

Filled with practical applications and research, Biodegradation of Nitroaromatic Compounds and Explosives presents an international perspective on environmental contamination from explosives. It covers biodegradation strategies for DNT and a wide variety of other nitroaromatic compounds of environmental significance and makes the information access

During the past five years increased awareness of environmental contamination by nitroaromatic compounds has led to a dramatic increase in research on their biodegradation. The resulting discoveries have markedly extended our understanding of degradation mecha nisms and pathways in bacteria and fungi. Futhermore, this new basic knowledge promises the development of field applications of biodegradation systems for nitroaromatic com pounds. In May of 1994, an International Symposium on the Biodegradation of Nitro aromatic Compounds was held in Las Vegas, Nevada. This symposium brought together the scientists at the frontiers of research into the biodegradation of nitro aromatic compounds. The invited speakers were asked to review their area of expertise and write a critical, comprehensive synthesis of their work and related work by others. This book is the result of their efforts. The emphasis of the reviews is on basic research in biodegradation and biotransfor mation. Therefore, the reactions of nitroaromatic compounds in plants, animals, bacteria, fungi, soil, and even nonbiological systems are considered. The goal of the work is to provide the reader with an appreciation of the tremendous range of possibilities for metabolism of aromatic nitro compounds and the experimental approaches used to understand them. This volume should be of interest to biochemists, microbiologists, engineers, toxicologists, and anyone interested in the behavior of synthetic chemicals in the environment or in living systems. Furthermore, a variety of commercial applications can be envisioned for some of the reactions described here.

Microbial degradation, Phytoremediation, Remediation, Explosive residues, Biotransformation, Mineralization, Degradative Enzymes, Degradation Pathways, Energetics, Soil contamination, Water contamination.

Our interest in the microbial biodegradation of xenobiotics has increased many folds in recent years to find out sustainable ways for environmental cleanup. Bioremediation and biotransformation processes harness the naturally occurring ability of microbes to degrade, transform or accumulate a wide range of organic pollutants. Major methodological breakthroughs in recent years through detailed genomic, metagenomic, proteomic, bioinformatic and other high-throughput analyses of environmentally relevant microorganisms have provided us unprecedented insights into key biodegradative pathways and the ability of organisms to adapt to changing environmental conditions. The degradation of a wide spectrum of organic pollutants and wastes discharged into the environment by anthropogenic activities is an emerging need today to promote sustainable development of our society with low environmental impact. Microbial processes play a major role in the removal of recalcitrant compounds taking advantage of the astonishing catabolic versatility of microorganisms to degrade or transform such compounds. New breakthroughs in sequencing, genomics, proteomics, bioinformatics and imaging are generating vital information which opens a new era providing new insights of metabolic and regulatory networks, as well as clues to the evolution of degradation pathways and to the molecular adaptation strategies to changing environmental conditions. Functional genomic and metagenomic approaches are increasing our understanding of the relative importance of different pathways and regulatory networks to carbon flux in particular environments and for particular compounds. New approaches will certainly accelerate the development of bioremediation technologies and biotransformation processes in coming years for natural attenuation of contaminated environments

2 DANNY D. REIBLEI AND KATERINA DEMNEROVA 1 Hazardous Substance Research Center/South and Southwest, Louisiana State University, Baton Rouge, LA 70803 2 Department of Biochemistry and Microbiology, Institute of Chemical Technology, Prague, Czech Republic On May 24, 2001, a total of 102 students and lecturers participated in an Advanced Study Institute (ASI) sponsored by the North Atlantic Treaty Organization (NATO) under our direction. The Institute was focused on in situ and onsite management of contaminated sites. The objective of the Institute was to balance state of the art science with techniques for field application of a variety of technologies for in situ assessment and remediation of contaminated sites. Many of the lecturers were drawn from the ranks of the Hazardous Substance Research Centers, multi-university consortia that have been funded by the US Environmental Protection Agency to conduct research and technology transfer designed to promote risk-based management and control of hazardous substances for the nation. The Centers have made special contributions to the areas of in situ and onsite assessment and remediation of contaminated sites. Such approaches have the potential for being significantly less expensive than other assessment and remediation approaches while maintaining accuracy and effectiveness. Cost-effective remedial and management approaches that are also effective in minimizing exposure and risk to human health and the environment are a critical need throughout the world but particularly in Eastern Europe and the former Soviet Union where resources that can be devoted to environmental cleanup are especially limited.

Sites contaminated with explosive compounds, pesticides, herbicides, PCBs, and other aromatic compounds present formidable technical, regulatory, and financial challenges. The application of bioremediation technologies to such sites offers the promise of cost-effective site remediation that can serve as a key component of a well-formulated strategy for achieving site closure. This volume presents the results of bench-, pilot-, and field-scale projects focused on the use of biological approaches to remediating problem compounds, such as RDX, HMX, TNT, DDT, 2, 4-D, nitro- and chlorobenzenes, nitroaniline, chloroaniline, hexachlorobenzene, PCPs, PCBs, and dichlorophenol in soils and groundwater.