Biological Delay Systems

In studying the dynamics of populations, whether of animals, plants or cells, it is crucial to allow for delays such as those due to gestation, maturation or transport. This book deals with a fundamental question in the analysis of the effects of delays, namely whether they affect the stability of steady states.

In studying the dynamics of populations, whether of animals, plants or cells, it is crucial to allow for intrinsic delays, due to such things as gestation, maturation or transport. This book is concerned with one of the fundamental questions in the analysis of the effect of delays, namely determining whether they effect the stability of steady states. The analysis is presented for one or two such delays treated both as discrete, where an event which occurred at a precise time in the past has an effect now, and distributed, where the delay is averaged over the population's history. Both of these types occur in biological contexts. The method used to tackle these questions is linear stability analysis which leads to an understanding of the local stability. By avoiding global questions, the author has kept the mathematical prerequisites to a minimum, essentially advanced calculus and ordinary differential equations.

Synchronization of chaotic systems, a patently nonlinear phenomenon, has emerged as a highly active interdisciplinary research topic at the interface of physics, biology, applied mathematics and engineering sciences. In this connection, time-delay systems described by delay differential equations have developed as particularly suitable tools for modeling specific dynamical systems. Indeed, time-delay is ubiquitous in many physical systems, for example due to finite switching speeds of amplifiers in electronic circuits, finite lengths of vehicles in traffic flows, finite signal propagation times in biological networks and circuits, and quite generally whenever memory effects are relevant. This monograph presents the basics of chaotic time-delay systems and their synchronization with an emphasis on the effects of time-delay feedback which give rise to new collective dynamics. Special attention is devoted to scalar chaotic/hyperchaotic time-delay systems, and some higher order models, occurring in different branches of science and technology as well as to the synchronization of their coupled versions. Last but not least, the presentation as a whole strives for a balance between the necessary mathematical description of the basics and the detailed presentation of real-world applications.

This book discusses the numerical treatment of delay differential equations and their applications in bioscience. A wide range of delay differential equations are discussed with integer and fractional-order derivatives to demonstrate their richer mathematical framework compared to differential equations without memory for the analysis of dynamical systems. The book also provides interesting applications of delay differential equations in infectious diseases, including COVID-19. It will be valuable to mathematicians and specialists associated with mathematical biology, mathematical modelling, life sciences, immunology and infectious diseases.

This volume collects contributions related to selected presentations from the 12th IFAC Workshop on Time Delay Systems, Ann Arbor, June 28-30, 2015. The included papers present novel techniques and new results of delayed dynamical systems. The topical spectrum covers control theory, numerical analysis, engineering and biological applications as well as experiments and case studies. The target audience primarily comprises research experts in the field of time delay systems, but the book may also be beneficial for graduate students alike.

In the mathematical description of a physical or biological process, it is a common practice \0 assume that the future behavior of Ihe process considered depends only on the present slate, and therefore can be described by a finite sct of ordinary diffe rential equations. This is satisfactory for a large class of practical systems. However. the existence of lime-delay elements, such as material or infonnation transport, of tcn renders such description unsatisfactory in accounting for important behaviors of many practical systems. Indeed. due largely to the current lack of effective metho dology for analysis and control design for such systems, the lime-delay elements arc often either neglected or poorly approximated, which frequently results in analysis and simulation of insufficient accuracy, which in turns leads to poor performance of the systems designed. Indeed, it has been demonstrated in the area of automatic control that a relatively small delay may lead to instability or significantly deteriora ted perfonnances for the corresponding closed-loop systems.

Time-delay occurs in many physical, industrial and engineering systems such as biological systems, chemical systems, metallurgical processing systems, nuclear reactors, hydraulic systems and electrical networks, to name a few. The reason for the occurrence could be attributed to inherent physical phenomena like mass transport flow or recycling. It could result from the finite capabilities of information processing and data transmission among various parts of the system. In addition, they could be by-products of computational delays or could be intentionally introduced for some design consideration. Such delays could be constant or time varying, known or unknown, deterministic or stochastic depending on the system under consideration. In recent years, time-delay, which exists in networked control systems, has brought more complex problems into a new research area. Frequently, it is a source of the generation of oscillation, instability and poor performance. Therefore, the subject of Time-Delay Systems (TDS) has been investigated as functional differential equations over the past four decades. Because the presence of the delay factor renders the system analysis more complicated, the problems of stability and stabilization are of great importance. This book presents some basic theories of stability and stabilization of systems with time-delays. More attention is paid to the synthesis of systems with time-delay. That is, control of nonlinear systems with delay; networked control systems; positive delay systems; fuzzy systems; and reset control with random delay are all analysed within this book.

An overall solution to the (robust) stability analysis and stabilisation problem of linear time-delay systems.