Bioprocessing Piping And Equipment Design

The only comprehensive and authoritative reference guide to the ASME Bioprocessing Piping and Equipment (BPE) standard This is a companion guide to the ASME Bioprocessing Piping and Equipment (BPE) Standard and explains what lies behind many of the requirements and recommendations within that industry standard. Following an introductory narrative to the Standard's early history, industry related codes and standards are explained; the design and engineering aspects cover construction materials, both metallic and nonmetallic; then components, fabrication, assembly and installation of piping systems are explored. Examination, Inspection and Testing then precede the ASME BPE certification process, concluding with a discussion on system design. The author draws on many years' experience and insights from first-hand involvement in the field of industrial piping design, engineering, construction, and management, which includes the bioprocessing industry. The reader will learn why dimensions and tolerances, process instrumentation, and material selection play such an integral part in the manufacture of components and instrumentation. This easy to understand and navigate guide will assist engineers (design, piping, chemical, etc.) who need to understand the basis for much of the Standard’s content, as do the contractors and inspectors who have to meet and validate compliance with the BPE Standard.

Serving as a companion guide to the ASME Bioprocessing Piping and Equipment (BPE) Standard and explaining what lies behind many of the requirements and recommendations within that industry standard, this book shows readers why dimensions and tolerances, process instrumentation, and material selection play such an integral part in the manufacture of components and instrumentation. --

Explains the mechanisms governing flow-induced vibrations and helps engineers prevent fatigue and fretting-wear damage at the design stage Fatigue or fretting-wear damage in process and plant equipment caused by flow-induced vibration can lead to operational disruptions, lost production, and expensive repairs. Mechanical engineers can help prevent or mitigate these problems during the design phase of high capital cost plants such as nuclear power stations and petroleum refineries by performing thorough flow-induced vibration analysis. Accordingly, it is critical for mechanical engineers to have a firm understanding of the dynamic parameters and the vibration excitation mechanisms that govern flow-induced vibration. Flow-Induced Vibration Handbook for Nuclear and Process Equipment provides the knowledge required to prevent failures due to flow-induced vibration at the design stage. The product of more than 40 years of research and development at the Canadian Nuclear Laboratories, this authoritative reference covers all relevant aspects of flow-induced vibration technology, including vibration failures, flow velocity analysis, vibration excitation mechanisms, fluidelastic instability, periodic wake shedding, acoustic resonance, random turbulence, damping mechanisms, and fretting-wear predictions. Each in-depth chapter contains the latest available lab data, a parametric analysis, design guidelines, sample calculations, and a brief review of modelling and theoretical considerations. Written by a group of leading experts in the field, this comprehensive single-volume resource: Helps readers understand and apply techniques for preventing fatigue and fretting-wear damage due to flow-induced vibration at the design stage Covers components including nuclear reactor internals, nuclear fuels, piping systems, and various types of heat exchangers Features examples of vibration-related failures caused by fatigue or fretting-wear in nuclear and process equipment Includes a detailed overview of state-of-the-art flow-induced vibration technology with an emphasis on two-phase flow-induced vibration Covering all relevant aspects of flow-induced vibration technology, Flow-Induced Vibration Handbook for Nuclear and Process Equipment is required reading for professional mechanical engineers and researchers working in the nuclear, petrochemical, aerospace, and process industries, as well as graduate students in mechanical engineering courses on flow-induced vibration.

Provides background information, historical perspective, and expert commentary on the ASME B31.3 Code requirements for process piping design and construction. It provides the most complete coverage of the Code that is available today and is packed with additional information useful to those responsible for the design and mechanical integrity of process piping.

Divided into four sections, the first and third reflect the fact that there are two types of equipment required in the plant--one in which the actual product is synthesized or processed such as the fermentor, centrifuge and chromatographic columns; and the other that supplies support for the facility or process including air conditioning, water and waste systems. Part two describes such components as pumps, filters and valves not limited to a certain type of equipment. Lastly, it covers planning and designing the entire facility along with requirements for containment and validation of the process.

The emergence and refinement of techniques in molecular biology has changed our perceptions of medicine, agriculture and environmental management. Scientific breakthroughs in gene expression, protein engineering and cell fusion are being translated by a strengthening biotechnology industry into revolutionary new products and services. Many a student has been enticed by the promise of biotechnology and the excitement of being near the cutting edge of scientific advancement. However, graduates trained in molecular biology and cell manipulation soon realise that these techniques are only part of the picture. Reaping the full benefits of biotechnology requires manufacturing capability involving the large-scale processing of biological material. Increasingly, biotechnologists are being employed by companies to work in co-operation with chemical engineers to achieve pragmatic commercial goals. For many years aspects of biochemistry and molecular genetics have been included in chemical engineering curricula, yet there has been little attempt until recently to teach aspects of engineering applicable to process design to biotechnologists. This textbook is the first to present the principles of bioprocess engineering in a way that is accessible to biological scientists. Other texts on bioprocess engineering currently available assume that the reader already has engineering training. On the other hand, chemical engineering textbooks do not consider examples from bioprocessing, and are written almost exclusively with the petroleum and chemical industries in mind. This publication explains process analysis from an engineering point of view, but refers exclusively to the treatment of biological systems. Over 170 problems and worked examples encompass a wide range of applications, including recombinant cells, plant and animal cell cultures, immobilised catalysts as well as traditional fermentation systems. * * First book to present the principles of bioprocess engineering in a way that is accessible to biological scientists * Explains process analysis from an engineering point of view, but uses worked examples relating to biological systems * Comprehensive, single-authored * 170 problems and worked examples encompass a wide range of applications, involving recombinant plant and animal cell cultures, immobilized catalysts, and traditional fermentation systems * 13 chapters, organized according to engineering sub-disciplines, are groupled in four sections - Introduction, Material and Energy Balances, Physical Processes, and Reactions and Reactors * Each chapter includes a set of problems and exercises for the student, key references, and a list of suggestions for further reading * Includes useful appendices, detailing conversion factors, physical and chemical property data, steam tables, mathematical rules, and a list of symbols used * Suitable for course adoption - follows closely curricula used on most bioprocessing and process biotechnology courses at senior undergraduate and graduate levels.

For mechanical and chemical engineers working for engineering construction as well as process manufacturing companies with responsibility for plant layout, piping, and construction; and for engineering students. Based on the authors' collective 65 years of experience in the engineering construction industry, this profusely illustrated, comprehensive guidebook presents tried-and-true workable methods and rules of thumb for plant layout and piping design for the process industries. Content is organized and presented for quick-reference on- the-job or for systematic study of specific topics. KEY TOPICS: Presents general concepts and principles of plant layout -- from basic terminology and input requirements to deliverables; deals with specific pieces of equipment and their most efficient layout in the overall plant design configuration; addresses the plant layout requirements for the most common process unit equipment; and considers the computerized tools that are now available to help plant layout and piping designers.

An up-to-date and practical reference book on piping engineering and stress analysis, this book emphasizes three main concepts: using engineering common sense to foresee a potential piping stress problem, performing the stress analysis to confirm the problem, and lastly, optimizing the design to solve the problem. Systematically, the book proceeds from basic piping flexibility analyses, springer hanger selections, and expansion joint applications, to vibration stress evaluations and general dynamic analyses. Emphasis is placed on the interface with connecting equipment such as vessels, tanks, heaters, turbines, pumps and compressors. Chapters dealing with discontinuity stresses, special thermal problems and cross-country pipelines are also included. The book is ideal for piping engineers, piping designers, plant engineers, and mechanical engineers working in the power, petroleum refining, chemical, food processing, and pharmaceutical industries. It will also serve as a reference for engineers working in building and transportation services. It can be used as an advance text for graduate students in these fields.