Bioresorbable Scaffolds

This book focuses on the coronary bioresorbable scaffold, a new interventional treatment for coronary artery disease, differentiated from a permanent metallic stent. The book provides an overview of the technology including non-clinical studies and clinical evidences in order to help clinicians understand the appropriate application of the technology and the optimal techniques of implantation. It covers the basics of bioresorbable scaffolds; bench test results; preclinical studies; clinical evidences; and tips and tricks of implantation.

The development and application of bioactive nano-structured constructs for tissue regeneration is the focus of the research summarised in this thesis. Moreover, a particular focus is the rational use of supercritical carbon dioxide foaming and electrospinning technologies which can lead to innovative polymeric bioresorbable scaffolds made of hydrolysable (both commercial and ‘ad-hoc’ synthesized) polyesters. Mainly, the author discusses the manipulation of polymer chemical structure and composition to tune scaffold physical properties, and optimization of scaffold 3D architecture by a smart use of both fabrication techniques. The multidisciplinary nature of this research is imperative in pursuing the challenge of tissue regeneration successfully. One of the strengths of this thesis is the integration of knowledge from chemistry, physics, engineering, materials science and biomedical science which has contributed to setting up new national and international collaborations, while strengthening existing ones.

This book addresses the principles, methods and applications of biodegradable polymer based scaffolds for bone tissue engineering. The general principle of bone tissue engineering is reviewed and the traditional and novel scaffolding materials, their properties and scaffold fabrication techniques are explored. By acting as temporary synthetic extracellular matrices for cell accommodation, proliferation, and differentiation, scaffolds play a pivotal role in tissue engineering. This book does not only provide the comprehensive summary of the current trends in scaffolding design but also presents the new trends and directions for scaffold development for the ever expanding tissue engineering applications.

The increasing pace of advances in cardiology throughout the last few decades has fundamentally altered the natural course of heart patients. In the last few years, available therapies have been revolutionized completely by new transcatheter therapeutic approaches, novel ventricular assist devices, and new drugs. Also, molecular biology and genetics have a rapidly growing impact on cardiovascular diseases, enabling the field of regenerative medicine to become increasingly closer to routine clinical implementation. Emerging Technologies for Heart Diseases was conceived to cover the recent extensive literature on current and novel therapeutic options for cardiac patients. The first volume is dedicated to heart failure and valvular disorders, and the second covers myocardial ischemia and arrhythmias. The clinical topic is addressed in several chapters divided according to the therapeutic approach (mechanical or electrical device-based, or cell and gene-based). Each of the 46 chapters focuses on clinically available solutions, new therapies currently under evaluation in clinical trials, promising preclinical technologies, and emerging concepts and innovations that have not yet been tested in a preclinical model. Also, the book discusses future challenges and opportunities for clinical implementation. Lessons learned from abandoned experimental practices are also covered, giving the readers the widest possible perspective of current therapeutic dilemmas. Overall, this textbook was designed for physicians who want to stay up-to-date with current therapies and those of the future, for biomedical companies, and for those who wish to broaden their knowledge of new cardiovascular therapeutic options. Provides a comprehensive review of the latest therapeutic developments for heart failure, valvular disorders, myocardial ischemia and arrhythmias, and their clinical implications Written by both specialists in the field and established researchers, it delivers a review of emerging medical technologies and presents insight into their therapeutic promise Chapters are arranged according to disease pathogeneses and relevance and include coverage of the mechanical, electrophysiological, and biological approaches for the management of patients with myocardial ischemia and arrhythmias

This issue of Cardiology Clinics will cover Coronary Artery Disease. Curated by Dr. Alberto Polimeni, this issue will explore topics in the field that are relevant for practicing clinicians. This issue is one of four selected each year by the series editorial board: Jamil A. Aboulhosn, David M. Shavelle, Terrence D. Welch, and Audrey H. Wu. The volume will include articles on: High sensitivity troponins in acute coronary syndromes, High bleeding risk patient with CAD, Complete revascularization in chronic coronary syndrome, Patient selection for protected PCI, Clinical applications of echo strain imaging in coronary artery disease, Mechanical circulatory support for cardiogenic shock, Impact of NO donors on atherogenesis and atherosclerosis progression, Non-invasive Imaging risk stratification for CAD, Antithrombotic therapy for patients with atrial fibrillation undergoing percutaneous coronary intervention, No-Reflow phenomenon, Coronary physiology assessment for the diagnosis and treatment of CAD, Bioresorbable coronary scaffold technologies, Non-coding RNAs in coronary artery disease, New advances in the treatment of severe coronary artery calcifications, and Refractory angina pectoris.

Make optimal use of the latest coronary stenting techniques and adjunctive devices with well-rounded guidance from Coronary Stenting, a companion volume to Dr. Topol’s Textbook of Interventional Cardiology. This comprehensive, up-to-date interventional cardiology book keeps you abreast of the latest trial data on efficacy and safety as well as cutting-edge clinical applications in coronary stenting. Achieve optimal outcomes and minimize complications with expert guidance from the foremost teachers and writers in the field of interventional cardiology. Implement the latest knowledge on cutting-edge topics such as drug-eluting stent design; appropriate interpretation of randomized clinical trials and comparative effectiveness studies of coronary stents; the use of fractional flow reserve, intravascular ultrasound and optical coherence tomography to optimize lesion selection and stent implantation; anterograde and retrograde approaches to chronic total occlusions; and percutaneous revascularization of diabetics and patients with left main or multivessel disease. Quickly and easily find the coronary stenting information you need thanks to highly templated chapters and high-quality full-color illustrations that incorporate the latest clinical trial data into recommendations for proper patient and device selection.

From new research and equipment to new procedures, applications, and approaches, the field of interventional cardiology is one of the fastest-changing areas in medicine. Increasing data and recent technological advances have resulted in exciting changes – and an even greater need for cutting-edge, authoritative guidance on current practice. Textbook of Interventional Cardiology, 8th Edition, covers the theories, trends, and applications of diagnostic and interventional cardiology that cardiologists, cardiac surgeons, vascular surgeons, referring physicians, and advanced practitioners need to know. Focuses on the latest treatment protocols for managing patients at every level of complexity. Includes all-new chapters on Coronary Stenting, Diagnosis and Treatment of Coronary Microvascular Disease, Percutaneous Transcatheter Valve in Valve Implantation, and Percutaneous Tricuspid Valve Repair. Features hundreds of new illustrations, tables, and boxes for visual clarity and quick reference. Offers expanded coverage of transcatheter aortic valve interventions with extensive updates on practice implications. Discusses hot topics such new atherectomy devices, percutaneous mitral valve replacement, and percutaneous treatment of paravalvular leak. Provides the unique insights of expert leaders in the field who have pioneered today’s innovative devices and techniques and lend their own analysis of practical, evidence-based clinical applications. Presents the most recent data on how genomics and genetics impact interventional cardiology. Provides an in-depth understanding of cardiology, making it well suited for cardiology and interventional cardiology exam preparation.

There has been significant progress in the field of interventional cardiology, from the development of newer devices to newer applications of technology, resulting in improved cardiovascular outcomes. The goal of this Special Issue is to update practicing clinicians and provide a comprehensive collection of original articles, reviews, and editorials. To this end, we invited state-of-the-art reviews, including reviews of new technology and therapeutics, as well as original research in this area to be considered for inclusion in this issue. Examples include the history and evolution of interventional techniques, reviews of specific devices and technologies for coronary artery disease (i.e., stent technology, atherectomy devices, coronary physiology, intracoronary imaging, and robotics), structural heart diseases (i.e., ASD: atrial septal defect; LAAC: left atrial appendage closure; MC: MitraClip; PFO: patent foramen ovale; TAVI: transcatheter aortic valve implantation), advances in the management of challenging coronary anatomy, new biomarkers of cardiovascular disease (noncoding RNAs, etc.), and interventional techniques in the management of heart failure, peripheral arterial diseases, and pulmonary embolism. This Special Issue presents the most recent advances in the field of coronary and structural heart diseases as well as their implications for future patient care.