Biotechnological Innovations In Chemical Synthesis

A self-study textbook for technicians seeking further education, graduates extending their knowledge base, experienced workers facing changes in jobs, managers unfamiliar with the new technology, and people returning after a career break. Explores some ways biotechnology can provide new routes for producing traditional organic chemical products and enable new products to replace those with environmental or other drawbacks. The aspects discussed include a biocatalyst in organic synthesis, the efficiency of growth and product formation, the production and diversification of antibiotics, and the industrial production of amino acids by fermentation and chemo-enzymatic methods.

The tremendous progress in biology over the last half century - from Watson and Crick's elucidation of the structure of DNA to today's astonishing, rapid progress in the field of synthetic biology - has positioned us for significant innovation in chemical production. New bio-based chemicals, improved public health through improved drugs and diagnostics, and biofuels that reduce our dependency on oil are all results of research and innovation in the biological sciences. In the past decade, we have witnessed major advances made possible by biotechnology in areas such as rapid, low-cost DNA sequencing, metabolic engineering, and high-throughput screening. The manufacturing of chemicals using biological synthesis and engineering could expand even faster. A proactive strategy - implemented through the development of a technical roadmap similar to those that enabled sustained growth in the semiconductor industry and our explorations of space - is needed if we are to realize the widespread benefits of accelerating the industrialization of biology. Industrialization of Biology presents such a roadmap to achieve key technical milestones for chemical manufacturing through biological routes. This report examines the technical, economic, and societal factors that limit the adoption of bioprocessing in the chemical industry today and which, if surmounted, would markedly accelerate the advanced manufacturing of chemicals via industrial biotechnology. Working at the interface of synthetic chemistry, metabolic engineering, molecular biology, and synthetic biology, Industrialization of Biology identifies key technical goals for next-generation chemical manufacturing, then identifies the gaps in knowledge, tools, techniques, and systems required to meet those goals, and targets and timelines for achieving them. This report also considers the skills necessary to accomplish the roadmap goals, and what training opportunities are required to produce the cadre of skilled scientists and engineers needed.

Biotechnology in the Chemical Industry: Towards a Green and Sustainable Future focuses on achievements and prospects for biotechnology in sustainable production of goods and services, especially those that are derived at present mostly from the traditional chemical industry. It considers the future impact of industrial biotechnology and lays out the major research areas which must be addressed to move from a flourishing set of scientific disciplines to a major contributor to a successful future knowledge-based economy. The book focuses on the research needed to underpin three broad topics: biomass, bio-processes and bio-products, including bio-energy. Readers, including advanced students, researchers, industry professionals, academics, analysts, consultants, and anyone else interested, or involved in biotechnology will find this book very informative. Offers a comprehensive introduction to the subject for researchers interested in the biotechnological applications in chemical industry Provides a state-of-the art update on the field Presents the economic and ecological advantages of industrial biotechnology Discusses efforts made by developing countries towards industrial biotechnology Describes new biotechnological applications Includes the major challenges facing industrial biotechnology

This book describes recent progress in enzyme-driven green syntheses of industrially important molecules. The first three introductory chapters overview recent technological advances in enzymes and cell-based transformations, and green chemistry metrics for synthetic efficiency. The remaining chapters are directed to case studies in biotechnological production of pharmaceuticals (small molecules, natural products and biologics), flavors, fragrance and cosmetics, fine chemicals, value-added chemicals from glucose and biomass, and polymeric materials. The book is aimed to facilitate the industrial applications of this powerful and emerging green technology, and catalyze the advancement of the technology itself.

Merrett provides a concise but comprehensive treatment of one of the central issues in environmental management. Informed by an evolutionary political economy perspective, this text draws on a worldwide range of case studies and examples.

Biotechnology Is A Multi-Disciplinary Course, Having Its Foundations In Many Fields Including Biology, Microbiology, Biochemistry, Molecular Biology, Genetics, Chemistry And Chemical Engineering. It Has Been Considered As A Series Of Enabling Technologies Involving The Practical Applications Of Organisms Or Their Cellular Components To Manufacturing And Service Industries And Environmental Management.Initially, Biotechnology Was An Art, Involved In The Production Of Wines, Beers And Cheese. Now It Involves Series Of Advance Technologies Spanning Biology, Chemistry And Process Engineering. In Recent Years Innovations Involving Genetic Engineering Have Had A Major Impact On Biotechnology. Its Applications Are Diverse, Including The Production Of New Drugs, Transgenic Organisms And Biological Fuels, Genetherapy And Clearing Up Pollution. It Is Also About Providing Cleaning Technology For A New Millennium; Of Providing Means Of Waste Disposal, Of Dealing With Environmental Problems. It Is In Short, One Of The Major Technology Of Twenty-First Century That Will Sustain Growth And Development In Countries Throughout The World For Several Decades To Come. It Will Continue To Improve The Standard Of Our Lives, From The Improved Medical Treatments Through Its Effects On Foods And Food Supply And To The Environment. No Aspect Of Our Lives Will Be Unaffected By Biotechnology.This Textbook On Biotechnology Has Been Written To Provide An Overview Of Many Of Fundamental Aspects That Underpin All Biotechnology And To Provide Examples Of How These Principles Are Put Into Operation, I.E. From The Starting Substrate Or Feed Stock Through The Final Product.The Textbook Also Caters To The Requirement Of The Syllabus Prescribed By Various Indian Universities For Undergraduate Students Pursuing Biotechnology, Applied Microbiology, Biochemistry And Biochemical Engineering.

Adopting a unique approach, this novel textbook integrates science and business for an inside view on the biotech industry. Peering behind the scenes, it provides a thorough analysis of the foundations of the present day industry for students and professionals alike: its history, its tools and processes, its markets and products. The authors, themselves close witnesses of the emergence of modern biotechnology from its very beginnings in the 1980s, clearly separate facts from fiction, looking behind the exaggerated claims made by start-up companies trying to attract investors. Essential reading for every student and junior researcher looking for a career in the biotech sector.

A thorough examination of the ways in which recent biotechnological developments have led to improvements in food processing. Deals with biotechnology based processes currently in use by or available to the food industry. Building on a series of case studies selected to illustrate the diversity of applications it clearly shows that biotechnology can and will benefit the food industry. The need for a cost-effective training scheme for new and existing staff at all levels has been met by the University of Greenwich (formerly Thames Polytechnic) and the Open University of the Netherlands. As part of the European Community Education and Technology Training initiative (COMETT) and in conjunction with a number of other leading UK and European universities, they have developed BIOTOL, a training scheme in biotechnology using open learning materials, which will provide tailor-made courses, flexible in content, pace and place.