Bone Biomaterials Beyond

The introduction of osseointegrated dental implants soon 50 years ago has indeed revolutionized dentistry. The scientific evaluation of their use has shown good and increasingly successful treatment outcomes. A prerequisite though is the availability of sufficient bone volumes to ensure integration and acceptable aesthetic results. In this book various surgical techniques, using different augmentation materials, are described and explained. The aim has been to highlight minimally invasive surgical techniques, which leads to less risk of morbidity and reduces treatment time. Readers will enjoy a comprehensive atlas providing some practical advices for every day surgical practice based on solid scientific evidence.

Bioactive Materials for Bone Regeneration summarizes research advances on the topic, including sections on the characteristics of biomaterial-induced microenvironments, interactions of bioactive materials with stem cells and tissues, and the immunomodulatory microenvironment induced by biomaterials and its effects on osteogenesis. As the regeneration of large-size bone tissue defects represents a significant clinical challenge, this book demonstrates how new biomaterials with specific chemical and physical characteristics may interact with the host and create a unique micro-environment that actively facilitates stem cell differentiation along a specific lineage, thus stimulating tissue regeneration. Provides readers with the latest research developments in the fabrication techniques of bioactive materials for tissue regeneration and tissue engineering applications Presents the latest research advancements on how bioactive materials interact with the host and induce micro-environments for stem cell differentiation, immunomodulation and tissue regeneration Covers the methods, strategies, principle and mechanisms on constructing beneficial biomaterial microenvironments

Bone Repair Biomaterials: Regeneration and Clinical Applications, Second Edition, provides comprehensive reviews on materials science, engineering principles and recent advances. Sections review the fundamentals of bone repair and regeneration, discuss the science and properties of biomaterials used for bone repair, including metals, ceramics, polymers and composites, and discuss clinical applications and considerations, with chapters on such topics as orthopedic surgery, tissue engineering, implant retrieval, and ethics of bone repair biomaterials. This second edition includes more chapters on relevant biomaterials and a greatly expanded section on clinical applications, including bone repair applications in dental surgery, spinal surgery, and maxilo-facial and skull surgery. In addition, the book features coverage of long-term performance and failure of orthopedic devices. It will be an invaluable resource for researchers, scientists and clinicians concerned with the repair and restoration of bone. Provides a comprehensive review of the materials science, engineering principles and recent advances in this important area Presents new chapters on Surface coating of titanium, using bone repair materials in dental, spinal and maxilo-facial and skull surgery, and advanced manufacturing/3D printing Reviews the fundamentals of bone repair and regeneration, addressing social, economic and clinical challenges Examines the properties of biomaterials used for bone repair, with specific chapters assessing metals, ceramics, polymers and composites

Dental Implants and Bone Grafts: Materials and Biological Issues brings together cutting-edge research to provide detailed coverage of biomaterials for dental implants and bone graft, enabling scientists and clinicians to gain a thorough knowledge of advances and applications in this field. As tooth loss and alveolar bony defects are common and pose a significant health problem in dental clinics, this book deals with timely topics, including alveolar bone structures and pathological changes, reviews of indications and advantages of biomaterials for dental implants and bone graft, design and surface modification, biological interaction and biocompatibility of modern dental implants and bone graft, and new frontiers. This book is a highly valuable resource for scientists, clinicians and implantologists interested in biomaterial and regenerative strategies for alveolar bone reconstruction. Focuses on the structure, function and pathology of alveolar bone system Considers the issues involved in selecting biomaterials for dental implants and bone grafts Discusses the requirements for optimal dental implant osseointegration and alveolar bone replacements/reconstruction Explains the biological basis of dental implants and bone grafts

This book focuses on the recent advances in the field of orthopaedic biomaterials, with a particular emphasis on their design and fabrication. Biomimetic materials, having similar properties and functions to that of the natural tissue, are becoming a popular choice for making customized orthopaedic implants and bone scaffolds. The acceptability of these materials in the human body depends on the right balance between their mechanical and biological properties. This book provides a comprehensive overview of the state-of-the-art research in this rapidly evolving field. The chapters cover different aspects of multi-functional biomaterials design, and cutting-edge methods for the synthesis and processing of these materials. Advanced manufacturing techniques, like additive manufacturing, used for developing new biomimetic materials are highlighted in the book. This book is a valuable reference for students and researchers interested in biomaterials for orthopaedic applications.

Translating Biomaterials for Bone Graft: Bench-top to Clinical Applications brings together the current translational research in bone tissue engineering, from design to application – from materials, drugs and biologic delivery used for bone graft applications to pre-clinical and clinical considerations. The book also discusses the regulatory approval pathways, which involves consideration of the class of devices; whether they are similar to existing solutions, minimal manipulation of donor tissue or completely novel materials, drugs and biologics. These considerations drive the ability to successfully transition the latest generations of bone graft materials into the clinics. Chapters come from materials scientists, clinicians, researchers, and consultants and provide a holistic understanding of the field. As such, the book is a state-of-the-art reference to bone therapies and should appeal to clinicians, scientists, as well as students interested in the current research and/or practices in the field of bone regeneration and restoration.

Volume is indexed by Thomson Reuters BCI (WoS). The aim of “Biomaterials for Bone Regenerative Medicine” is to review extensively the latest developments in Biomaterials and their application to bone regeneration in vivo. Indeed, research on biomaterials and their novel applications is essential because of the health issues related to the aging population. A wide range of worldwide investigations is being undertaken by eminent scholars in order to develop further innovative materials for next-generation applications. In future, it is expected that a tissue engineering approach, associating novel biomaterials with stem cells, will be available for all types of bone defect.

As collagen is the main structural component of body tissues, there has been much effort expended, both in the past and today, to use it in cell culture applications. Indeed, its importance is further stressed by the wide use of collagen biomaterials in tissue repair and regeneration, including the treatment of burns, chronic wounds or bone repair. This book represents a journey through recent scientific history, and describes the massive implications of the research carried out by Bornstein, Ehrmann and Gey on collagen preparations in the 1950s for cell culture and more recently, tissue engineering and personalised medicine.