Brain Inflamed

From renowned integrative physician Kenneth Bock, M.D., comes a groundbreaking approach to understanding adolescent and teen mental health disorders. Over the past decade, the number of 12- to 17-year-olds suffering from mental health disorders has more than doubled. While adolescents and teens are notorious for mood swings and rebellion, parents today are navigating new terrain as their children are increasingly at risk of struggling with a mental health issue. But the question remains: What is causing this epidemic of illness? In Brain Inflamed, acclaimed integrative doctor Dr. Kenneth Bock shares a revolutionary new view of adolescent and teen mental health—one that suggests many of the mental disorders most common among this population (including depression, anxiety, and OCD) may share the same underlying mechanism: systemic inflammation. In this groundbreaking work, Dr. Bock explains the essential role of the immune system and the microbiome in mental health, detailing the ways in which imbalances in these systems—such as autoimmune conditions, thyroid disorders, or leaky gut syndrome—can generate neurological inflammation. While most conventional doctors assume that teens’ psychological struggles can be resolved only with therapy and psychotropic drugs, Dr. Bock’s approach considers the whole-body health of his patients. In his integrative evaluations, he often uncovers triggers such as gluten sensitivity, adrenal dysfunction, Lyme disease, and post-strep infections—all of which create imbalances in the body that can generate psychological symptoms. Filled with incredible stories from Dr. Bock’s more than thirty years as a practicing physician, Brain Inflamed explains the biological underpinnings of many common mental health issues, and empowers the parents and family members of struggling teens with practical advice—and perhaps most importantly, hope for a brighter future.

As seen on "CBS This Morning" Worldwide, depression will be the single biggest cause of disability in the next twenty years. But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still...until now with Edward Bullmore's The Inflamed Mind: A Radical New Approach to Depression. A Sunday Times (London) Top Ten Bestseller In this game-changing book, University of Cambridge profressor of psychiatry Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycles of stress, inflammation, and depression. The Inflamed Mind goes far beyond the clinic and the lab, representing a whole new way of looking at how mind, brain, and body all work together in a sometimes misguided effort to help us survive in a hostile world. It offers insights into how we could start getting to grips with depression and other mental disorders much more effectively in the future.

This PIR volume presents a comprehensive collection of reviews that focus on the role of the blood-brain barrier (BBB) during steady-state and inflamed conditions. Within the central nervous system (CNS) the constantly changing bloodstream is strictly separated from the CNS parenchyma by the BBB. However, viruses, bacteria, parasites and auto-aggressive immune cells can penetrate the barrier and significantly contribute to CNS inflammation. The BBB can actively contribute to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alterations of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential to the development of new drugs to efficiently combat inflammatory diseases of the CNS.

A comprehensive program that targets all four of the 4-A epidemics: autism, ADHD, asthma, and allergies “An easy-to-read commonsense guide to beneficial biomedical treatments.”—Temple Grandin Doctors have generally overlooked the connections among the 4-A disorders. For years the medical establishment has considered autism medically untreatable and utterly incurable, and has limited ADHD treatment mainly to symptom suppression. Dr. Kenneth Bock, a leading medical innovator, along with his colleagues, have discovered a solution that goes to the root of the problem. They have found that modern toxins, nutritional deficiencies, metabolic imbalances, genetic vulnerabilities, and assaults on the immune and gastrointestinal systems trigger most of the symptoms of the 4-A disorders, resulting in frequent misdiagnosis and untold mysteries. Dr. Bock’s remarkable Healing Program is an innovative biomedical approach that has changed the lives of more than a thousand children. Drawn from medical research and based on years of clinical success, this program offers a safe, sensible solution that is individualized to each child to help remedy the root causes. Dr. Bock also shares the dramatic true stories of parents and children that will inspire you to change the life of your own child. Hope is at last within reach.

'My first serious blackout marked the line between sanity and insanity. Though I would have moments of lucidity over the coming days and weeks, I would never again be the same person ...' Susannah Cahalan was a happy, clever, healthy twenty-four-year old. Then one day she woke up in hospital, with no memory of what had happened or how she had got there. Within weeks, she would be transformed into someone unrecognizable, descending into a state of acute psychosis, undergoing rages and convulsions, hallucinating that her father had murdered his wife; that she could control time with her mind. Everything she had taken for granted about her life, and who she was, was wiped out. Brain on Fire is Susannah's story of her terrifying descent into madness and the desperate hunt for a diagnosis, as, after dozens of tests and scans, baffled doctors concluded she should be confined in a psychiatric ward. It is also the story of how one brilliant man, Syria-born Dr Najar, finally proved - using a simple pen and paper - that Susannah's psychotic behaviour was caused by a rare autoimmune disease attacking her brain. His diagnosis of this little-known condition, thought to have been the real cause of devil-possessions through history, saved her life, and possibly the lives of many others. Cahalan takes readers inside this newly-discovered disease through the progress of her own harrowing journey, piecing it together using memories, journals, hospital videos and records. Written with passionate honesty and intelligence, Brain on Fire is a searingly personal yet universal book, which asks what happens when your identity is suddenly destroyed, and how you get it back. 'With eagle-eye precision and brutal honesty, Susannah Cahalan turns her journalistic gaze on herself as she bravely looks back on one of the most harrowing and unimaginable experiences one could ever face: the loss of mind, body and self. Brain on Fire is a mesmerizing story' -Mira Bartók, New York Times bestselling author of The Memory Palace Susannah Cahalan is a reporter on the New York Post, and the recipient of the 2010 Silurian Award of Excellence in Journalism for Feature Writing. Her writing has also appeared in the New York Times, and is frequently picked up by the Daily Mail, Gawker, Gothamist, AOL and Yahoo among other news aggregrator sites.

This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.

What do feeling sick and being afraid of strangers have in common? The answer is that these feelings represent a behavioural drive which evolved in our ancestors to combat the most dangerous threat to survival: infection. Behaviour and emotions play pivotal roles in the struggle for good health. When your body is telling your brain that you are sick, you are experiencing survival strategies that developed years ago. Listening to these feelings will allow you to save energy that can be used for recuperation and recovery. Urges of staying still, noticing pain, feeling sorry for yourself, and focusing inward are bodily messages that benefit immune defence. For our forefathers, in whom these strategies evolved, it wasn't enough to change behaviour once sick. Defensive behaviours to be able to avoid infection in the first place were also needed. Thus, tools for detecting illness in others evolved. This is why superficial signs of ill-health, or maybe even the prejudicial idea of a person with a foreign bacterial culture, can cause anxiety and avoidance. Not surprisingly, having a too high or too low sensitivity to inner or outer disease signals is connected to mental as well as somatic disorders. In this book, Mats Lekander explains the science behind perceived health, using Barbie dolls, visual illusions, personal experiences, placebo, hypochondriacs and historical anecdotes. Placed against a back-drop of the latest neuroscience and psychoneuroimmunology he explains why you feel healthy or sick. He describes when he poisoned himself at work and enjoyed it, and why white blood cells and inflammation are key players when our brains trys to guess what is going in our inner worlds. The result is an absorbing and eye-opening book, one that seems so relevant in the current times.

An innovative and integrative avenue toward understanding and treating mental health disorders Psychoimmunology is a rapidly maturing area of scientific endeavor that provides a compelling integrative link between the immune system and its response to stress and psychiatric illness. Stress initiates pathological changes by activating the immune and endocrine systems. Inflammation is at the core of the complex and interactive systems that both contribute to and result from psychopathology. Consequently, inflammation research advances our knowledge of the pathology of depression, schizophrenia, chronic fatigue syndrome, posttraumatic stress disorder and a host of co- morbid conditions, notably diabetes, cardiovascular disease and cerebrovascular disease. The possible mechanisms underlying the bidirectionality of co-morbid medical and psychiatric disorders can be viewed as a consequence of inflammatory changes. These emerging novel concepts illustrate how the knowledge of inflammation can enable meaningful integration of psychopathology with physical co- morbidity. The innovative articles in this volume highlight the intricate link between psychiatry and psychoimmunology and underscore the central role of inflammation in furthering our understanding of the pathophysiology underlying mental health and illness.