Cancer Radioimmunotherapy
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Radioimmunotherapy of Cancer
Author | : Paul G. Abrams,Alan R. Fritzberg |
Publsiher | : CRC Press |
Total Pages | : 416 |
Release | : 2000-07-11 |
Genre | : Medical |
ISBN | : 9780824741921 |
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Reflecting the past 20 years of intense research in radioimmunotherapy, this timely reference surveys an expansive breadth of topics on the evolving developments in radiation therapy. Placed in the context of advances in cancer treatment, chapters progress systematically from basic principles and properties of radionuclides to detailed summaries of
Radioimmunotherapy Translational Opportunities and Challenges
Author | : Udo S. Gaipl,Gabriele Multhoff,Alan Graham Pockley,Franz Rödel |
Publsiher | : Frontiers Media SA |
Total Pages | : 144 |
Release | : 2020-03-13 |
Genre | : Electronic Book |
ISBN | : 9782889636150 |
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Cancer Therapy with Radiolabeled Antibodies
Author | : David M. Goldenberg |
Publsiher | : CRC Press |
Total Pages | : 574 |
Release | : 2018-01-18 |
Genre | : Law |
ISBN | : 9781351087308 |
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Cancer Therapy with Radiolabeled Antibodies explores the most current experimental and clinical advances in the newly emerging field of cancer radioimmunotherapy (RAIT). Providing a multidisciplinary and international context, some of the world's leading experts examine the problems and prospects of RAIT from radiation, immunological, chemical, physical, physiological, and clinical perspectives with both overviews and original research. Discussions cover the up-to-date clinical results in the RAIT of ovarian, breast, colorectal, and brain cancers, as well as the current status of RAIT in the management of B cell lymphomas. Radiobiology, dosimetry, radiochemistry, targeting biology in experimental models, clinical experiences in hematopoietic and solid tumors, and new approaches to improve cancer radioimmunotherapy are also discussed. In addition, new dosimetry concepts, new labeling methods, new concepts of antibody pharmacokinetics, and new methods to enhance selective cancer radioimmunotherapy are included.
Radioimmunotherapy of Cancer
Author | : Paul G. Abrams,Alan R. Fritzberg |
Publsiher | : CRC Press |
Total Pages | : 416 |
Release | : 2000-03-29 |
Genre | : Medical |
ISBN | : 1135568162 |
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Reflecting the past 20 years of intense research in radioimmunotherapy, this timely reference surveys an expansive breadth of topics on the evolving developments in radiation therapy. Placed in the context of advances in cancer treatment, chapters progress systematically from basic principles and properties of radionuclides to detailed summaries of current cancer therapies. Up to date, clearly organized, and thorough-sure to become a standard in the field! Providing comprehensive treatment on radiolabeled antibody therapy, Radioimmunotherapy of Cancer reviews dosimetric principles and clinical dosimetry of radioimmunotherapy in the targeting and delivery of radiation describes tumor architectures and outlines novel constructs for radionuclide delivery analyzes a variety of improved targeting approaches, including pretargeting contextual analysis of extracorporeal techniques in radioimmunotherapy details studies from the radiotherapy of lymphoma, solid tumors, and ovarian cancer and the targeted radiotherapy of neuroblastoma and squamous head and neck cancer and much more! With contributions from nearly 50 international experts and containing over 1300 literature references, drawings, photographs, tables, and equations, Radioimmunotherapy of Cancer is an invaluable and indispensable reference for physicians in nuclear medicine and medical physicists; oncologists, radiologists, radiochemists, and radiopharmacists; immunologists, pulmonologists, and cancer researchers; pharmacologists and drug delivery pharmaceutical chemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.
Cancer Radioimmunotherapy
Author | : Pietro Riva |
Publsiher | : CRC Press |
Total Pages | : 530 |
Release | : 1998-09-01 |
Genre | : Medical |
ISBN | : 9057023091 |
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This book represents an update of investigations devoted to the utilization of new biological probes, conjugated to suitable radioisotopes, for the treatment of different solid and hematological tumors. Much progress has been made since the original findings of monoclonal antibodies, but several problems have to be resolved before this particular therapeutic approach can be applied extensively.
Systemic Radiotherapy with Monoclonal Antibodies
Author | : Marie-Luise Sautter-Bihl,Heiner Bihl,Michael Wannenmacher |
Publsiher | : Springer Science & Business Media |
Total Pages | : 200 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 9783642799525 |
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Almost a century ago Paul Ehrlich introduced the "magic bullet" concept of targeting therapeutic agents to specific tissues in order to reduce systemic toxicity. Due to the advances in hybridoma technology in the 1980s, monoclonal antibodies (MAbs) with their exquisite affinity to tumor antigens have become powerful tools in the treatment of cancer, especially when linked to therapeutic agents such as radionuclides, drugs, toxins, or enzymes. It can now be expected that such agents will lead to new cancer treatments with high therapeutic success rates. However, there are major problems in developing this therapeutic concept to a routine treatment modality. This is partly due to factors such as heterogenous distribution of tumor antigens, insufficient blood supply of tumors, high interstitial pressure, and the large interstitial space that antibodies have to traverse. This book is focused on the development in radio immunotherapy (RIT) using radio labeled monoclonal antibodies as tumoritoxic agents. This area of research has attracted the interest of clinicians and scientists from many different disciplines. It is now clear that the full potential of RIT can only be realized through the concerted efforts of laboratory scientists (molecular biologists, cell physiologists, chemists, radiation physicists, and biologists) and cancer clinicians in nuclear medicine, radiooncology, and internal oncology.
Radioimmunoimaging and Radioimmunotherapy
Author | : Scott W. Burchiel,Buck A. Rhodes |
Publsiher | : Elsevier Publishing Company |
Total Pages | : 484 |
Release | : 1983 |
Genre | : Medical |
ISBN | : UOM:39015006032463 |
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Targeted Radionuclide Therapy
Author | : Tod W. Speer |
Publsiher | : Lippincott Williams & Wilkins |
Total Pages | : 564 |
Release | : 2012-03-28 |
Genre | : Medical |
ISBN | : 9781451153262 |
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Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.