Care Use And Welfare Of Marmosets As Animal Models For Gene Editing Based Biomedical Research

The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop.

"The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop"--Publisher's description

AAP Prose Award Finalist 2018/19 Management of Animal Care and Use Programs in Research, Education, and Testing, Second Edition is the extensively expanded revision of the popular Management of Laboratory Animal Care and Use Programs book published earlier this century. Following in the footsteps of the first edition, this revision serves as a first line management resource, providing for strong advocacy for advancing quality animal welfare and science worldwide, and continues as a valuable seminal reference for those engaged in all types of programs involving animal care and use. The new edition has more than doubled the number of chapters in the original volume to present a more comprehensive overview of the current breadth and depth of the field with applicability to an international audience. Readers are provided with the latest information and resource and reference material from authors who are noted experts in their field. The book: - Emphasizes the importance of developing a collaborative culture of care within an animal care and use program and provides information about how behavioral management through animal training can play an integral role in a veterinary health program - Provides a new section on Environment and Housing, containing chapters that focus on management considerations of housing and enrichment delineated by species - Expands coverage of regulatory oversight and compliance, assessment, and assurance issues and processes, including a greater discussion of globalization and harmonizing cultural and regulatory issues - Includes more in-depth treatment throughout the book of critical topics in program management, physical plant, animal health, and husbandry. Biomedical research using animals requires administrators and managers who are knowledgeable and highly skilled. They must adapt to the complexity of rapidly-changing technologies, balance research goals with a thorough understanding of regulatory requirements and guidelines, and know how to work with a multi-generational, multi-cultural workforce. This book is the ideal resource for these professionals. It also serves as an indispensable resource text for certification exams and credentialing boards for a multitude of professional societies Co-publishers on the second edition are: ACLAM (American College of Laboratory Animal Medicine); ECLAM (European College of Laboratory Animal Medicine); IACLAM (International Colleges of Laboratory Animal Medicine); JCLAM (Japanese College of Laboratory Animal Medicine); KCLAM (Korean College of Laboratory Animal Medicine); CALAS (Canadian Association of Laboratory Animal Medicine); LAMA (Laboratory Animal Management Association); and IAT (Institute of Animal Technology).

This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.

Animal Experimentation: Working Towards a Paradigm Change critically appraises current animal use in science and discusses ways in which we can contribute to a paradigm change towards human-biology based approaches.

The seminal reference on the care of laboratory and captiveanimals, The UFAW Handbook on the Care and Management ofLaboratory and Other Research Animals is a must-have for anyoneworking in this field. The UFAW Handbook has been thedefinitive text since 1947. Written for an international audience,it contains contributions from experts from around the world. The book focuses on best practice principles throughout, providingcomprehensive coverage, with all chapters being peer reviewed byanonymous referees. As well as addressing the husbandry oflaboratory animals, the content is also of great value to zoos andaquaria. Changes for the eighth edition: Revised and updated to reflect developments since publicationof the previous edition. New chapters on areas of growing concern, including: the 3Rs;phenotyping; statistics and experimental design; welfareassessment; legislation; training of people caring for lab animals;and euthanasia. All material combined into one volume for ease ofreference. This book is published on behalf of UFAW (The UniversitiesFederation for Animal Welfare), with whom we also publish theUFAW/Wiley-Blackwell Animal Welfare Book Series. This majorseries of books provides an authoritative source ofinformation on worldwide developments, current thinking and bestpractice in the field of animal welfare science and technology. Fordetails of all of the titles in the series see ahref="http://www.wiley.com/go/ufaw"www.wiley.com/go/ufaw/a.

Handbook of Primate Husbandry and Welfare covers all aspects of primate care and management both in the laboratory environment and in zoos. From the welfare and ethics of primate captivity through to housing and husbandry systems, environmental enrichment, nutritional requirements, breeding issues, primate diseases, and additional information on transportation and quarantine proceedings, this book provides a completely comprehensive guide to good husbandry and management of primates. Designed to be a practical field manual, the authors present the material using lists, tables and illustrations to clarify best practice. Representative species are covered – from marmosets through to macaques One of the first books dedicated to the care of primates in captivity Written by authors with many years of experience working with primates Suitable for those working with primates in either laboratories or zoos