Cavernous Malformations

The massive convergence of information about cavernous malformations has been synthesized in this volume by experts in the field of pathology, neuroradiology and neurosurgery. Cavernous Malformations represents state-of-the-art knowledge about this lesion and the spectrum of opinion about its nature, clinical behavior and management strategies. Highlights of Cavernous Malformations: Definition and pathologic features Epidemiology Diagnostic imaging Epilepsy Hemorrhage Conservative management Surgical intervention Microsurgical treatments Spinal cavernous malformations Pediatrics Radiotherapy (Distributed by Thieme for the American Association of Neurological Surgeons)

This book presents a complete up-to date description of cavernoma disease together with its known biology, genetics and variable clinical presentation. It facilitates improved decision-making on surgical intervention by presenting different cases, highlighting the particular features of lesions such as anatomical location, eloquences of adjacent brain and type of presentation that are important when making decisions. In addition, the reader is brought up to speed with developments in the neuroimaging and active treatment techniques, especially surgical resection and radiosurgery. Finally, the natural history of the disease is taken into account and compared to the possible benefits of surgical treatment. Cavernomas of the CNS: Basic Science to Clinical Practice provides a comprehensive overview from the fundamentals of this condition, to special patient groups such as children and pregnant women. Therefore, it is an indispensable resource for neurovascular surgeons, neurosurgical residents and neurologists.

Arteriovenous and Cavernous Malformations, Volume 143, is the latest addition in the ongoing HCN series, an evidence-based compendium which addresses both the scientific and clinical aspects of this unique disease process. The volume covers didactic aspects, such as the epidemiology, etiology, and diagnosis of AVMs, while also providing expert clinical information on the management and treatment of these lesions. In addition, it provides coverage of modern-day advances in the genetics of cavernous malformations, as well as discussion regarding future open research questions. Readers from the laboratory bench to the bedside can expect a broad, yet objective, review of this pathology, with updates from the latest scientific literature and data supporting current practices. Offers an evidence-based focus with coverage of both the scientific and clinical aspects of cavernous malformations Addresses epidemiology, etiology, diagnosis, and genetics Contains clinical insights regarding indications for surgery, surgical techniques, outcomes, and prognostic factors drawn from the authors' extensive experiences Edited work with chapters authored by leaders in the field from around the globe – the broadest, most expert coverage available

Questions regarding the nature and appropriate management of cavernous malformation (CM) have clouded researchers and those faced with making clinical decisions for several decades. CMs may be seen as an incidental finding on MRI studies, or they may present with symptoms, such as seizures or intracranial hemorrhage, often causing severe neurologic deficit. Cavernous Malformations of the Nervous System provides a comprehensive and authoritative review of the current practice in diagnosis and management of these cerebrovascular disorders. Emphasis has been laid on the understanding of basic sciences with chapters committed to understanding of CCM1, 2 and 3 genes and their role in CCM biology, as well as clinical genetics. Controversial topics which continue to pose treatment challenges such as safety of anticoagulation and prophylactic management during pregnancy are also discussed. This book will be of interest to basic science researchers, neurosurgeons and vascular neurologists both in academic institutions and private practice.

Current techniques for clinical management This book presents a comprehensive overview of the basic science and current clinical knowledge on cavernous malformations of the brain and spinal cord. Cavernous Malformations of the Brain and Spinal Cord begins by covering general aspects of the disease, including the natural history, molecular biology, pathological processes, genetic basis, neuroradiology, and classification of cavernous malformations. Separate chapters then address the various types of cavernous malformations, thoroughly describing the clinical presentation and management approaches for each clinical situation. Incisive review of recent literature sheds light on topics of incidence, location, and outcomes. Features: Clinical insights regarding indications for surgery, surgical techniques, outcomes, and prognostic factors drawn from the authors' extensive experiences Discussion of treatment of patients with specific disorders, such as epilepsy Coverage of cavernous malformations as dynamic lesions with descriptions of de novo formation and lesions induced by irradiation Neurosurgeons, neurologists, and neuroradiologists, especially those caring for patients with seizures and hemorrhagic stroke, will benefit from the wealth of information in this complete reference.

Current techniques for clinical management This book presents a comprehensive overview of the basic science and current clinical knowledge on cavernous malformations of the brain and spinal cord. Cavernous Malformations of the Brain and Spinal Cord begins by covering general aspects of the disease, including the natural history, molecular biology, pathological processes, genetic basis, neuroradiology, and classification of cavernous malformations. Separate chapters then address the various types of cavernous malformations, thoroughly describing the clinical presentation and management approaches for each clinical situation. Incisive review of recent literature sheds light on topics of incidence, location, and outcomes. Features: Clinical insights regarding indications for surgery, surgical techniques, outcomes, and prognostic factors drawn from the authors' extensive experiences Discussion of treatment of patients with specific disorders, such as epilepsy Coverage of cavernous malformations as dynamic lesions with descriptions of de novo formation and lesions induced by irradiation Neurosurgeons, neurologists, and neuroradiologists, especially those caring for patients with seizures and hemorrhagic stroke, will benefit from the wealth of information in this complete reference.

This book presents, in a stepwise and interactive fashion, approximately 75 cases that reflect the wide spectrum of pathology encountered in this region. Each case description commences with a concise clinical scenario. High-quality radiologic, laboratory, and histopathologic images depicting the differentiating features of the lesion subtype in question are then presented, and key operative and clinical management pearls are briefly reviewed. The interdisciplinary nature of this easy-to-use color atlas and textbook reflects the fact that the management of patients with sellar and parasellar lesions is itself often interdisciplinary. The format is unique in that no similar interdisciplinary book is available on lesions of this region of the brain. Atlas of Sellar and Parasellar Lesions: Clinical, Imaging, and Pathologic Correlations is of great value for practitioners and trainees in a range of medical specialties, including radiology, neurology, endocriniology, pathology, oncology, radiation oncology, and neurosurgery.

Toole's Cerebrovascular Disorders was the first modern book devoted to care of the stroke, originally published more than 40 years ago. This is a completely revised and updated sixth edition of the highly respected standard for stroke diagnosis and treatment. Dr James Toole has stayed on as a consultant for the text, and Drs E. Steve Roach, Kerstin Bettermann, and Jose Biller have reworked Dr Toole's book to include chapters on genetics, pregnancy-related stroke, and acute treatments. The practical focus of the book has not changed, retaining its emphasis on bedside diagnosis and treatment. Easily accessible both for stroke specialists and residents, the sixth edition has been modernized to keep pace with the rapid expansion of knowledge in stroke care and includes evidence-based recommendations, the latest technology and imaging, and risk factors. The text is supplemented with more than 200 images, many in color.