Chitosan For Biomaterials Iv

This volume presents the recent developments on the biomedical applications of chitosan and its derivatives. Chitosan exhibits unique properties such as non-toxicity, biodegradability and biocompatibility. Since its chemical structure and properties can be easily modified, it can be an ideal candidate as a biomaterial. Consequently, chitosan and its derivatives are being developed in different forms such as nanoparticles, micelles, nanofibers, hydrogels, films and 3D porous materials for various biomedical applications, ranging from drug and gene delivery to tissue engineering and regenerative medicine. The chapters of this volume focus on the potential use of chitosan and its derivatives as a hemostatic agent, tissue sealants, tissue engineering scaffolds, delivery carriers for bioactive molecules in bone tissue engineering and wound dressings. Some chapter’s deal with recent advancements of chitosan-based biomaterials as a drug, gene and transdermal drug delivery carrier. In addition, the volume focusses on the prospects of chitosan-based systems for the treatment of cancer, eye and other infectious diseases. The volume will be of interest to material scientists, chemists and biotechnologists by providing a better understanding of the physicochemical and biological characteristics of chitosan and its derivatives to develop more appropriate and innovative chitosan-based materials modified for unlimited practical applications in biomedical fields.

This volume presents the recent developments on the biomedical applications of chitosan and its derivatives. Chitosan exhibits unique properties such as non-toxicity, biodegradability and biocompatibility. Since its chemical structure and properties can be easily modified, it can be an ideal candidate as a biomaterial. Consequently, chitosan and its derivatives are being developed in different forms such as nanoparticles, micelles, nanofibers, hydrogels, films and 3D porous materials for various biomedical applications, ranging from drug and gene delivery to tissue engineering and regenerative medicine. The chapters of this volume focus on the potential use of chitosan and its derivatives as a hemostatic agent, tissue sealants, tissue engineering scaffolds, delivery carriers for bioactive molecules in bone tissue engineering and wound dressings. Some chapter's deal with recent advancements of chitosan-based biomaterials as a drug, gene and transdermal drug delivery carrier. In addition, the volume focusses on the prospects of chitosan-based systems for the treatment of cancer, eye and other infectious diseases. The volume will be of interest to material scientists, chemists and biotechnologists by providing a better understanding of the physicochemical and biological characteristics of chitosan and its derivatives to develop more appropriate and innovative chitosan-based materials modified for unlimited practical applications in biomedical fields.

Polymeric Bionanocomposites as Promising Materials for Controlled Drug, by M. Prabaharan, R. Jayakumar; Chitosan and Chitosan Derivatives in Drug Delivery and Tissue Engineering, by R. Riva, H. Ragelle, A. des Rieux, N. Duhem, C. Jérôme, and V. Préat; Chitosan: A Promising Biomaterial for Tissue Engineering Scaffolds, by P. K. Dutta, K. Rinki and J. Dutta; Chitosan-Based Biomaterials for Tissue Repair and Regeneration, by X. Liu, L. Ma, Z. Mao and C. Gao; Use of Chitosan as a Bioactive Implant Coating for Bone-Implant Applications, by M. R. Leedy, H. J. Martin, P. A. Norowski, J. A. Jennings, W. O. Haggard, and J.D. Bumgardner; New Techniques for Optimization of Surface Area and Porosity in Nanochitins and Nanochitosans, by R. A. A. Muzzarelli; Production, Properties and Applications of Fungal Cell Wall Polysaccharides: Chitosan and Glucan, by N. New, T. Furuike, and H. Tamura;

Chitosan Based Biomaterials: Fundamentals, Volume 1, provides the latest information on chitosan, a natural polymer derived from the marine material chitin. Chitosan displays unique properties, most notably biocompatibility and biodegradability. It can also be easily tuned to modify its structure or properties, making chitosan an excellent candidate as a biomaterial. Consequently, chitosan is being developed for many biomedical functions, ranging from tissue engineering and implant coatings to drug and gene delivery. This book looks at the fundamentals of chitosan-based biomaterials. Contains specific focus on the techniques and technologies needed to develop chitosan for biomedical applications Presents a comprehensive treatment of the fundamentals Provides contributions from leading researchers with extensive experience in chitosan

Chitosan Based Biomaterials: Tissue Engineering and Therapeutics, Volume 2, provides the latest information on chitosan, a natural polymer derived from the marine material chitin. Chitosan displays unique properties, most notably biocompatibility and biodegradability. It can also be easily tuned to modify its structure or properties, making chitosan an excellent candidate as a biomaterial. Consequently, chitosan is being developed for many biomedical functions, ranging from tissue engineering and implant coatings to drug and gene delivery. This book provides readers with a full coverage of the applications of chitosan-based biomaterials. Presents specific focus on tissue engineering and therapeutics Provides comprehensive treatment of all biomaterial applications of chitosan Contains contributions by leading researchers with extensive experience in the material

The second edition of Chitin underscores the important factors for standardizing chitin processing and characterization. It captures the essential interplay between chitin's assets and limitations as a biomaterial, placing the past promises of chitin in perspective, addressing its present realities and offering insight into what is required to realize chitin's destiny (including its derivative, chitosan) as a biomaterial of the twenty-first century. This book is an ideal guide for both industrialists and researchers with a vested interest in commercializing chitin. An update on the research since 2001 as it pertains to the biomaterials and biomedical applications of chitin and chitosan An expanded discussion on positioning chitin and chitosan for biomedical applications Presents regulatory aspects of chitin and chitosan

This book delves deeply in to the preparation, characterization and multiple applications of chitin and chitosan. The 17 chapters written by leading experts is an excellent reference source and state-of-the-art review for researchers and scientists using chitosan or biopolymers in their respective areas. This book is divided into following sections: • Production and derivatives of chitosan • Chitosan in the textile and food industries • Chitosan in biomedical applications • Chitosan in agriculture and water treatment The book is practical as readers will be able to see descriptions of chitosan production methods as well as techniques that can be used to estimate and modify their physical and chemical properties. It provides a full description not only of the traditional and recent developments in the applications of chitosan in the fields of biotechnology, environmental studies, food, medicine, water treatments, drug delivery, but it includes all of the therapeutically usages as well.

In recent years there have been tremendous advances in the fields of chemistry, physics and biology which have a direct impact on advances in biomaterials science. These advances have contributed significantly to the improvement of modern health care and continue to influence the practice of medicine. A biomaterial is any material, natural or man-made, that comprises whole or part of a living structure or biomedical device which performs, augments, or replaces a natural function. Among the biomaterials, chitin and chitosan have received much attention due to their non-toxicity, biodegradability, biocompatibility and multifunctional properties with applications in biomedical and pharmaceutical sciences. The main driving force behind the development of new applications for chitin and its derivative chitosan lies with the fact that these polysaccharides represent a renewable source of natural biodegradable polymers. Since chitin is the second most abundant natural polymer, academic as well as industrial scientists are faced with a great challenge to find new and practical applications for this material. This book provides an examination of the state of the art, and discusses current research as well as new biomedical applications of chitin and chitosan. Applications of chitin and chitosan will be of interest to industrial personnel involved in bioprocessing as well as bioengineering students, specialists in the biomedical and biopharmaceutical industry, biochemists, food engineers, environmentalists, and microbiologists and biologists who specialize in chitosan technology. The subject matter of the book is divided into nine chapters. Chapter 1 deals with the preparation and physico-chemical properties of amphiphilic derivatives of chitin and chitosan. The potential applications of these derivatives in the fields of controlled drug and gene delivery are discussed in details. Chapter 2 deals with the inhibitory activity of chitosan against bacteria and fungi potentially encountered in foodstuffs and the modes of action as suggested in the literature. Recent approaches, such as enzymatic depolymerization and chemical modifications, developed to improve the bioactivity of chitosan are reported. In addition, the applications of chitosan based products as biopackaging materials in food preservation are explored. In chapter 3, the recent developments and applications of stimuli-responsive materials based on chitosan are discussed. Moreover, different approaches used to prepare chitosan interpenetrating networks are analyzed and the potential of the resultant system for biomedical applications are critically reviewed. Different methods of chitosan deposition onto substrates for tissue engineering, wound dressing, separation membranes, biocompatible and antibacterial coatings, stent coatings, and sensors applications are reported in chapter 4. Chapter 5 of this book deals with the mechanisms involved in the in vitro calcification of chitosan while chapter 6 discusses the role of chitosan and its derivatives as potent adjuvant/delivery systems for mucosal immunization both in human and veterinary medicine. The current research and developments on chitin and chitosan nanoscaffolds for tissue engineering applications and future demands on bio-products are discussed in chapter 7. Chapter 8 reviews the different techniques of chitosan microsphere preparation for the drug delivery applications. In addition, the advantages of using chitosan microsphere as drug carrier are also explored. Recently, considerable works have been directed to develop an ideal scaffold based on polymer/ceramic composite materials. In this context, chitosan/calcium phosphate composite materials would have an importance in bone tissue engineering. The preparation methods, properties and applications of composite scaffolds and cements based on calcium phosphate and chitosan are reported in chapter 9. We hope this book can serve as a comprehensive introduction to researchers in biomaterials science and engineering in general, and can also be used as a graduate level text in related areas. We thank the authors for their excellent contributions to this book and our publishers for their encouragement which motivated us to produce this book. We believe this will make a lasting contribution to the field of biomaterials science.