Separation Methods in Drug Synthesis and Purification

Separation Methods in Drug Synthesis and Purification
Author: Klara Valko
Publsiher: Elsevier
Total Pages: 790
Release: 2020-06-19
Genre: Science
ISBN: 9780444640710

Download Separation Methods in Drug Synthesis and Purification Book in PDF, Epub and Kindle

Separation Methods in Drug Synthesis and Purification, Second Edition, Volume Eight, provides an updated on the analytical techniques used in drug synthesis and purification. Unlike other books on either separation science or drug synthesis, this volume combines the two to explain the basic principles and comparisons of each separation technique. New sections to this volume include enantiomer separation using capillary electrophoresis (CE) and capillary electro- chromatography, the computer simulation of chromatographic separation for accelerating method development, the application of chromatography and capillary electrophoresis used as surrogates for biological processes, and new developments in the established techniques of chromatography and preparative methods. Features descriptions and applications of all separation methods used in the pharmaceutical industry Written by the leading scientists in their respective fields, providing solutions for a wide range of industrial separation problems encountered within the pharmaceutical industry Thoroughly updated with brand new separation science techniques and the latest developments in the established techniques of chromatography

Chiral Separation Methods for Pharmaceutical and Biotechnological Products

Chiral Separation Methods for Pharmaceutical and Biotechnological Products
Author: Satinder Ahuja
Publsiher: John Wiley & Sons
Total Pages: 400
Release: 2011-03-31
Genre: Science
ISBN: 1118097750

Download Chiral Separation Methods for Pharmaceutical and Biotechnological Products Book in PDF, Epub and Kindle

Discusses chiral separations and offers guidance for selectingthe optimum method for desired results Chiral separations represent the most intriguing and, by somemeasures, most difficultseparations of chemical compounds. Thisbook provides researchers and students an under-standing of chiralseparations and offers a convenient route to selecting the bestseparation method, saving considerable time and cost in productdevelopment. Considering chiral separations in the biotechnological andpharmaceutical industries, as well as for food applications, Dr.Ahuja provides insights into a broad range of topics. Opening witha broad overview of chiral separations, regulatory considerationsin drug product development, and basic issues in methoddevelopment, the book: Covers a variety of modern methods such as gas chromatography,high performance liquid chromatography, supercritical fluidchromatography, and capillary electrophoresis Deals with the impact of chirality on the biological activity ofsmall and large molecules Provides detailed information on useful chiral stationary phases(CSPs) for HPLC Includes handy information on selection of an appropriate CSP,including mechanistic studies Offers strategies for fast method development with HPLC, SFC,and CE Discusses preparatory methods utilized in the pharmaceuticalindustry With in-depth discussions of the current state of the field aswell as suggestions to assist future developments, ChiralSeparation Methods for Pharmaceutical and BiotechnologicalProducts is an essential text for laboratory investigators,managers, and regulators who are involved in chiral separations inthe pharmaceutical industry, as well as students preparing forcareers in these fields.

Preparative Chromatography for Separation of Proteins

Preparative Chromatography for Separation of Proteins
Author: Arne Staby,Anurag S. Rathore,Satinder Ahuja
Publsiher: John Wiley & Sons
Total Pages: 577
Release: 2017-03-06
Genre: Technology & Engineering
ISBN: 9781119031109

Download Preparative Chromatography for Separation of Proteins Book in PDF, Epub and Kindle

Preparative Chromatography for Separation of Proteins addresses a wide range of modeling, techniques, strategies, and case studies of industrial separation of proteins and peptides. • Covers broad aspects of preparative chromatography with a unique combination of academic and industrial perspectives • Presents Combines modeling with compliantce useing of Quality-by-Design (QbD) approaches including modeling • Features a variety of chromatographic case studies not readily accessible to the general public • Represents an essential reference resource for academic, industrial, and pharmaceutical researchers

Identification and Quantification of Drugs Metabolites and Metabolizing Enzymes by LC MS

Identification and Quantification of Drugs  Metabolites and Metabolizing Enzymes by LC MS
Author: Swapan Chowdhury
Publsiher: Elsevier
Total Pages: 354
Release: 2005-11-04
Genre: Science
ISBN: 0080456065

Download Identification and Quantification of Drugs Metabolites and Metabolizing Enzymes by LC MS Book in PDF, Epub and Kindle

As new techniques of transferring from liquid to gas phase and measuring masses of drug molecules and metabolites become more prevalent, so do the technical challenges of putting these techniques into proper use, as well as the task of consolidating emerging applications. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS, Volume 6 fills the gap in the lack of presently available literature by providing a critical review in the current use of liquid chromatography-mass spectrometry (LC-MS) in drug discovery and development. With chapters written by experts with a wide range of practical experience from the pharmaceutical industry, emphasis is placed on techniques and applications. The book also includes chapters on how to utilize LC-MS instrumentation for current drug metabolism problems. This book is intended for those beginning to use LC-MS for drug metabolism studies as well as for those considered advanced practitioners. * Introduces readers to the practical applications of modern liquid chromatography-mass spectrometry (LC-MS) in a wide range of drug metabolism studies· * Provides a comprehensive description of different forms of metabolites, with detailed discussion on the wide range of methodologies used to identify them * Highlights problems associated with drug quantification and offers practical solutions

Chiral Separations

Chiral Separations
Author: D. Stevenson,I.D. Wilson
Publsiher: Springer Science & Business Media
Total Pages: 203
Release: 2012-12-06
Genre: Science
ISBN: 9781461566342

Download Chiral Separations Book in PDF, Epub and Kindle

This volume represents the proceedings of a two-day international meeting on chiral chromatography held at the University of Surrey between 3-4 September 1987. The meeting was jointly organized by the Chromatographic SOCiety and the Robens Institute of the University of Surrey in response to the burgeoning interest in this rapid maturing field of chromatography. Nowhere is this interest more evident than in the agrochemical and pharmaceutical industries where the implications of different pharmacological and toxicological activity for the individual enantiomers present in a racemic drug ol" insecticide is an increasing area of concern. Developments in the area of chiral separations are at last beginning to provide SCientists with the necessary tools to study how animals and man handle racemates and relate their obseIVations to the obseIVed biological effects of these substances. The development of robust and Simple methods for the separation of enantiomers will therefore have a profound Impact on safety evaluation and drug design. The meeting proved to be very successful. with over 160 delegates from thirteen countries in Europe and America present to learn from the experiences of experts in the field of chiral chromatography and to hear about the latest developments. Hopefully. in future symposia on chiral separations at the University of Surrey.

Chromatography and Its Applications

Chromatography and Its Applications
Author: Sasikumar Dhanarasu
Publsiher: BoD – Books on Demand
Total Pages: 214
Release: 2012-03-16
Genre: Science
ISBN: 9789535103578

Download Chromatography and Its Applications Book in PDF, Epub and Kindle

Chromatography is a powerful separation tool that is used in all branches of science, and is often the only means of separating components from complex mixtures. The Russian botanist Mikhail Tswett coined the term chromatography in 1906. The first analytical use of chromatography was described by James and Martin in 1952, for the use of gas chromatography for the analysis of fatty acid mixtures. A wide range of chromatographic procedures makes use of differences in size, binding affinities, charge, and other properties. Many types of chromatography have been developed. These include Column chromatography, High performance liquid chromatography (HPLC), Gas chromatography, Size exclusion chromatography, Ion exchange chromatography etc. In this book contains more details about the applications of chromatography by various research findings. Each and every topics of this book have included lists of references at the end to provide students and researchers with starting points for independent chromatography explorations. I welcome comments, criticisms, and suggestions from students, faculty and researchers.

HPLC for Pharmaceutical Scientists

HPLC for Pharmaceutical Scientists
Author: Yuri V. Kazakevich,Rosario LoBrutto
Publsiher: John Wiley & Sons
Total Pages: 1080
Release: 2007-02-16
Genre: Science
ISBN: 9780470087947

Download HPLC for Pharmaceutical Scientists Book in PDF, Epub and Kindle

HPLC for Pharmaceutical Scientists is an excellent book for both novice and experienced pharmaceutical chemists who regularly use HPLC as an analytical tool to solve challenging problems in the pharmaceutical industry. It provides a unified approach to HPLC with an equal and balanced treatment of the theory and practice of HPLC in the pharmaceutical industry. In-depth discussion of retention processes, modern HPLC separation theory, properties of stationary phases and columns are well blended with the practical aspects of fast and effective method development and method validation. Practical and pragmatic approaches and actual examples of effective development of selective and rugged HPLC methods from a physico-chemical point of view are provided. This book elucidates the role of HPLC throughout the entire drug development process from drug candidate inception to marketed drug product and gives detailed specifics of HPLC application in each stage of drug development. The latest advancements and trends in hyphenated and specialized HPLC techniques (LC-MS, LC-NMR, Preparative HPLC, High temperature HPLC, high pressure liquid chromatography) are also discussed.

Handbook of Pharmaceutical Analysis

Handbook of Pharmaceutical Analysis
Author: Lena Ohannesian,Anthony Streeter
Publsiher: CRC Press
Total Pages: 605
Release: 2001-11-09
Genre: Medical
ISBN: 9780824741945

Download Handbook of Pharmaceutical Analysis Book in PDF, Epub and Kindle

Exploring the analysis of pharmaceuticals, including polymorphic forms, this book discusses regulatory requirements in pharmaceutical product development and pharmaceutical testing. It covers methods of drug separation and procedures such as capillary electrophoresis for chromatographic separation of molecules. Additional topics include drug formulation analysis using vibrational and magnetic resonance spectroscopy and identification of drug metabolites and decomposition products using such techniques as mass spectrometry. The book provides more than 300 tables, equations, drawings, and photographs, and convenient, easy-to-use indices, facilitating quick access to each topic.