Clinical And Molecular Aspects Of Cardiomyopathies On The Road From Gene To Therapy An Issue Of Heart Failure Clinics E Book

This issue of Heart Failure Clinics--edited by Drs. Giuseppe Limongelli, Sharlene Day, and Perry Elliott--will cover Clinical and Molecular Aspects of Cardiomyopathies: On the Road from Gene to Therapy. Topics include, but are not limited to, Epidemiology and Clinical aspects of Genetic Cardiomyopathies, Existing and New therapies, Gene editing and gene-based therapeutics, Controversies surrounding exercise in genetic cardiomyopathies, Genetic infiltrative cardiomyopathies, LV Noncompaction, Clinical presentation and natural history of hypertrophic cardiomyopathy in Rasopathies, and Moelcular basis and new treatments of cardiac diseases in Rasopathies.

This issue explores the genetic basis of specific cardiomyopathies and phenotypic components of heart failure with an eye to the clinical implications of this genetic knowledge. An understanding of the genetic causes of disease can aid in development of effective prevention and management strategies.

This issue explores the genetic basis of specific cardiomyopathies and phenotypic components of heart failure with an eye to the clinical implications of this genetic knowledge. An understanding of the genetic causes of disease can aid in development of effective prevention and management strategies.

In this issue of Veterinary Clinics: Small Animal Practice, guest editor Dr. Joshua Stern brings his considerable expertise to the topic of Advancements in Companion Animal Cardiology. Cardiovascular disease of companion animals has seen a boom in research productivity and novel therapies that make the future of cardiac care very bright. In this issue, top experts highlight advances in diagnosis and treatment for common cardiac diseases such as hypertrophic cardiomyopathy, mitral valve degeneration, and dilated cardiomyopathy. Contains 12 relevant, practice-oriented topics including hypertrophic cardiomyopathy: advances in imaging and diagnostic strategies; the genetics of canine pulmonary valve stenosis; mitral valve repair: surgical outcomes and the rise of interventional options; the role of personalized medicine in companion animal cardiology; the role of point-of-care thoracic ultrasound in managing cardiac emergencies; and more. Provides in-depth clinical reviews on advancements in companion animal cardiology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Clinical management and signs are the focus of this practical cardiogenetic reference for those who are involved in the care for cardiac patients with a genetic disease. With detailed discussion of the basic science of cardiogenetics in order to assist in the clinical understanding of the topic. The genetic causes of various cardiovascular diseases are explained in a concise clinical way that reinforces the current management doctrine in a practical manner. The authors will cover the principles of molecular genetics in general but also specific to cardiac diseases. They will discuss the etiology, pathogenesis, pathophysiology, clinical presentation, clinical diagnosis, molecular diagnosis and treatment of each cardiogenetic disease separately. Therapy advice, ICD indications, indications for and manner of further family investigation will all be covered, while each chapter will also contain take-home messages to reinforce the key points. The chapters reviewing the different diseases will each contain a table describing the genes involved in each. Each chapter will also contain specific illustrations, cumulatively giving a complete, practical review of each cardiogenetic disease separately. Special emphasis will be given to advice on how to diagnose and manage cardiogenetic diseases in clinical practice, which genes should be investigated and why, and the pros and cons of genetic testing. Guidelines for investigation in families with sudden cardiac death at young age will also be included. This book will be written for the general cardiologist and the clinical geneticist who is involved in cardiac patients and will provide answers to question such as: Which genes are involved and which mutations? What is the effect of the mutation at cellular level? Which genes should be tested and why? What is the value of a molecular diagnosis? Does it influence therapy? When should the first degree relatives be tested and in which way?

In this issue of Cardiac Electrophysiology Clinics, guest editors Drs. Rafik Tadros, Julia Cadrin-Tourigny, and Jason D. Roberts bring their considerable expertise to the topic of Inherited Cardiac Diseases Predisposing to Sudden Death. Top experts in the field cover key topics such as genetic counseling and genetic testing in inherited heart disease; implantable devices in genetic heart disease; gene-based therapy in inherited arrythmias and cardiomyopathies; personalized care in long QT syndrome; and more. Contains 16 relevant, practice-oriented topics including novelties in Brugada syndrome: complex genetics, risk stratification and catheter ablation; novel approaches to treatment of catecholaminergic polymorphic ventricular tachycardia; investigation of unexplained cardiac arrest: phenotyping and genetic testing; impact of imaging to arrhythmic risk stratification in non-ischemic cardiomyopathy; and more. Provides in-depth clinical reviews on inherited cardiac diseases predisposing to sudden death, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Clinical management and signs are the focus of this practical cardiogenetic reference for those who are involved in the care for cardiac patients with a genetic disease. With detailed discussion of the basic science of cardiogenetics in order to assist in the clinical understanding of the topic. The genetic causes of various cardiovascular diseases are explained in a concise clinical way that reinforces the current management doctrine in a practical manner. The authors will cover the principles of molecular genetics in general but also specific to cardiac diseases. They will discuss the etiology, pathogenesis, pathophysiology, clinical presentation, clinical diagnosis, molecular diagnosis and treatment of each cardiogenetic disease separately. Therapy advice, ICD indications, indications for and manner of further family investigation will all be covered, while each chapter will also contain take-home messages to reinforce the key points. The chapters reviewing the different diseases will each contain a table describing the genes involved in each. Each chapter will also contain specific illustrations, cumulatively giving a complete, practical review of each cardiogenetic disease separately. Special emphasis will be given to advice on how to diagnose and manage cardiogenetic diseases in clinical practice, which genes should be investigated and why, and the pros and cons of genetic testing. Guidelines for investigation in families with sudden cardiac death at young age will also be included. This book will be written for the general cardiologist and the clinical geneticist who is involved in cardiac patients and will provide answers to question such as: Which genes are involved and which mutations? What is the effect of the mutation at cellular level? Which genes should be tested and why? What is the value of a molecular diagnosis? Does it influence therapy? When should the first degree relatives be tested and in which way?

In the last decade, genetics has been emerging as a primary issue in the diagnosis and management of cardiomyopathies. This book is intended to be a state-of-the-art monograph on these diseases, describing their genetic causes, defining the molecular basis and presenting extensive descriptions of genotype–phenotype correlations. Other chapters are focused on the role of clinical observation, on ECG and echocardiography. With its highlight on the most recent discoveries in the field of molecular genetics as well as on the correct clinical approach to patients with heart muscle disease, the book is aimed at physicians and clinical cardiologists with a particular interest in myocardial diseases and in their genetic causes.