Clinical Diabetes Research

A practical "how to" guide for multiple methods in metabolism, with a critical and objective discussion of strengths, limitations, and appropriate applications of the described methods. Edited by the winner of the Oskar-Minkowski Prize of the EASD in 2006 Clinical trials in populations at risk of or with overt diabetes mellitus are being performed all around the world to test novel drugs and approaches to managing these diseases. During the last decade, new methods and techniques have been introduced – and are being developed further – that facilitate monitoring of metabolism and even diagnosis of certain defects in human metabolism. While some of these methods are restricted to research facilities, others are already used in clinical practice. The correct beneficial use of these methods requires knowledge of the nature of the techniques and their clinical relevance. Clinical Diabetes Research: Methods and Techniques provides summaries of established state-of-the art-techniques and introduces the new technologies, evaluating their potential in clinical diabetes research. One section compares the efficacy of all metabolic tests that measure insulin action. Another section describes methods that allow quantification of whole body and intracellular metabolic fluxes relevant to diabetes research. The final section focuses on the planning and pitfalls of clinical studies in the field of metabolism. Each chapter throughout the book combines the theoretical basis of the approach with practical recommendations. There are further chapters on the design of clinical trials and ethical considerations. The publication is timely in view of the impressive development of the methods and techniques with their application to understanding the pathophysiology of diabetes, insulin resistance syndromes, obesity, and the metabolic effects of treatment. Clinical Diabetes Research: Methods and Techniques is of great relevance for researchers (from students and post-docs to principal investigators) in the field of human metabolism, clinical endocrinologists and diabetologists who are involved in clinical studies.

An unprecedented compilation of state-of-the-art advances in clinical research on diabetes and obesity by premier clinical scientists around the world. This volume critically reviews the limitations and strengths of today's major techniques in clinical diabetes research, and then reviews how those methods have been used to carry out cutting-edge studies of carbohydrate, lipid, and protein metabolism in the disease.

Diabetes mellitus is a major public health problem affecting over 415 million people in the world. Extensive research over the decades and the recent discovery of new medicines have revolutionized our understanding and treatment of both type 2 diabetes and type 1 diabetes mellitus. This book contains selected topics that describe recent advances in research, and state of the art treatment of the two types of diabetes mellitus and their complications. The topics encompass epidemiology and pathogenesis of diabetes, clinical features, diagnosis and treatment of diabetes and related complications. The chapters contain essential background materials, as well as recent advances in researches in different aspects of diabetes mellitus. The books is expected to be useful for researchers, research students, as well as for the clinicians engaged in diabetes care and diabetes research.

An unprecedented compilation of state-of-the-art advances in clinical research by premier clinical scientists around the world. This volume discusses the methods of clinical research and the interpretation of their results in studies of normal individuals, obese subjects, and patients with diabetes mellitus. Along the way, the authoritative contributors writing here illuminate how changes in the hormone action and substrate metabolism of healthy humans may lead to obesity and noninsulin-dependent diabetes mellitus.

Reviews of the first two editions: The primary source of information on diabetes for health professionals who deal with diabetic patients. - Annals of Internal Medicine Outstanding...the physician who is interested in diabetes mellitus should buy this book.-The New England Journal of Medicine Comprehensive and up-to-date...a solid introduction to the basic science of diabetes with a wealth of practical clinical information. - JAMA Do your patients ask you questions such as: What new types of insulin treatment are available? Why are pills not as safe and effective as insulin treatment? What is the genetic risk to an individual of developing diabetes? What can at-risk individuals do to prevent the onset of diabetes? For straightforward and informed answers to questions like these, turn to Clinical Diabetes Mellitus: A Problem Oriented Approach. The third edition of this acclaimed work represents the state-of-the-art in diabetes research, diagnosis, and management - in a unique problem-oriented format. Reflecting Dr. Davidson's more than 50 years of experience in the research and care of diabetic patients, this format offers direct solutions to the problems diabetes care professionals face everyday. The book features several new chapters and is divided into seven sections covering: the nature of diabetes mellitus; screening and diagnosis; long-term management; complications; concomitant problems; socioeconomic problems; and the development and evaluation of diabetes care programs. Inside, you'll find insightful analysis of epidemiology, pathophysiology, patient adherence, the latest research, and more. Plus, the book provides state-of-the-art information on everything from new insulin analogues and treatment methods to diabetes education and the significance of the Diabetes Control and Complications Trial. Highlights of the third edition: New chapters on cranial and peripheral neuropathy, autonomic neuropathy, and musculoskeletal problems in diabetes Comprehensive chapters on the team approach to diagnosis and treatment of diabetes with detailed information on how to deal with psychosocial problems New recommendations of the American Diabetes Association for the diagnosis of Type 1, Type 2, and gestational diabetes mellitus Thorough presentations on all diabetes related complications, including retinopathy, nephropathy, heart disease, cerebrovascular disease, and the diabetic foot Helpful information on the public health responses of the CDC and diabetes research programs of the NIDDK and NIH Contributions from 106 world-class authors from the U.S., Canada, and Europe For comprehensive, up-to-date, and clinically relevant information on diabetes mellitus, this book is unparalleled. It is an essential addition to the working library of diabetologists, endocrinologists, internists, family practitioners, and any member of the health care team involved in the treatment of the diabetic patient. It is also a must for medical school and hospital libraries.

Diabetes has garnered worldwide attention and research funding as clinicians and researchers seek to better understand its pathogenesis, prevention, complications management, and impact and relationship to other diseases (heart disease, kidney disease, infections, and inflammation). Clinicians are overwhelmed with rapidly evolving developments regarding the science and clinical management of diabetes and are struggling to understand and apply new diabetes information. Diabetes: Translating Research into Practice will provide a concise interpretation of translational diabetes research for the purpose of preparing clinicians to understand and effectively deploy new strategies and therapeutics into the clinical care of diabetes patients by examining: the contrast between existing information in the clinical practice versus the basis and need for future clinical trials breakthroughs within clinical trials and methods to incorporate bench to bedside material for the clinical practice the synthesis and interpretation of the scientific principles, trial results, and clinical implications of emerging and translational therapies, and the management strategies for diabetic patients the entire scope of translational diabetes research from biology to screening and prognosis, new therapeutics, insulin, transplantation, and complications management new therapeutic strategies to knowledgeably and effectively equip the practicing clinician assembles information that is scattered throughout the diabetic community into one concise single reference

Diabetes mellitus is a chronic disease of absolute or relative insulin deficiency or resistance characterised by disturbances in carbohydrate, protein and fat metabolism. It is estimated that between 5-10 per cent of the population suffer from this disease. This syndrome is a contributing factor in a large percentage of deaths from heart attacks and strokes as well as renal failure and vascular disease. About 90 per cent of the cases of diabetes mellitus fall into Type 2 where obesity plays a major role. Research in the field is wide-spread ranging from causes to treatment. This book brings together leading research from throughout the world.

Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. These two common co-morbidities lead to substantial increase in cardiovascular disease, the major cause of morbidity and mortality of adults around the world. In Diabetes and Hypertension: Evaluation and Management, a panel of renowned experts address a range of critical topics -- from basic concepts in evaluation and management of diabetes and hypertension, such as dietary interventions, to evaluation and management of secondary hypertension in clinical practice. Other chapters focus on high cardiovascular risk populations such as those with coronary heart disease, chronic kidney disease and minority patients. In addition, evolving concepts and new developments in the field are presented in other chapters, such as prevention of type 2 diabetes and the epidemic of sleep apnea and its implication for diabetes and hypertension evaluation and management. An important title covering two of the most troubling disorders of our time, Diabetes and Hypertension: Evaluation and Management will provide the busy practitioner with cutting edge knowledge in the field as well as practical information that can translate into better care provided to the high-risk population of diabetics and hypertensive patients.