Comparative Immunology Of Marine Mammals

Marine mammals (MMs) are regarded as valuable bioindicators with tremendous potential for public health. However, many aspects of their immune system remain poorly understood. Monitoring immune responses of MMs is pivotal for the health assessment of both individuals and populations, as well as providing the scientific basis for analyzing the anthropogenic environmental impact on marine ecosystems and marine-terrestrial interphases. For instance, the increasing susceptibility of Mediterranean whale and dolphin populations to various diseases has been linked to a possible negative influence of multiple environmental factors on the immune system of MMs. The currently limited knowledge on MM immunology has mainly centered on: (i) lymphocyte transformation assays; (ii) natural killer cell activity; (iii) phagocytic activity and respiratory burst; (iv) humoral immune responses; (v) cytokines and (vi) acute phase immune responses. Therefore, further research is essential for deepening our understanding of the specificity of the host immune response in MMs, with a particular emphasis on the genesis and dynamics of (i) cytokine ‘networks’ or ‘signatures’; (ii) transcriptional regulation of immune cells and (iii) major immunomodulators. High-throughput molecular techniques, such as transcriptomic analysis and RNA sequencing, may enable the characterization of immune gene responses at the transcriptomic level. This integrative and holistic approach requires sophisticated tools and methods capable of unveiling the diversity of immune cells and immunologically relevant molecules that orchestrate environmental adaptation and immune protection against pathogens in MMs. This Research Topic aims to provide a comprehensive overview of the current knowledge of MM immunology with a particular emphasis on structural and functional studies at the protein and cellular level. We wish to encourage and coordinate studies and investigations in order to fill gaps of knowledge in this field. This article collection aims to help gain more data regarding: a) The characterization of the immune system in several species of MMs, i.e. cetaceans, pinnipeds and sirenians; b) The interplay between the host immune system and the most relevant pathogens, e.g., Morbillivirus, Brucella, Toxoplasma gondii and c) The possible interplay between the immune system and contaminants.

Comparative Mammalian Immunology: The Evolution and Diversity of the Immune Systems of Mammals provides a review on the current knowledge of mammalian immune systems from a comparative viewpoint. This reference encompasses recent work on the immune systems of marine mammals, bats and marsupials in addition to other lesser-known species, with the immune systems of humans and laboratory mice as components of chapters on primates and rodents respectively. The book also makes use of the most recent studies on the genomic sequences of the mammals to identify both common and unique features of each mammal's immune system. The book elucidates the complex, but coordinated and controlled series of interactions involving cells and molecules that has evolved to protect the host against disease. Mammals consist of a highly diverse group of animals in which the immune system has been subjected to a variety of selective pressures. This is reflected in differences in the organization and function of their immune systems, and is especially seen in those gene families characterized by complexity and polymorphism. Demonstrates multiple diverse pathways and mechanisms to optimize resistance and survival in the face of infectious diseases Shows the clear patterns of emergence of different immunologic traits among the diverse orders of mammals Reflects issues with innate or adaptive immune systems Serves as a comprehensive review of the current state of knowledge of the immune system of each mammalian order

Immunologists, perhaps understandably, most often concentrate on the human immune system, an anthropocentric focus that has resulted in a dearth of information about the immune function of all other species within the animal kingdom. However, knowledge of animal immune function could help not only to better understand human immunology, but perhaps more importantly, it could help to treat and avoid the blights that affect animals, which consequently affect humans. Take for example the mass death of honeybees in recent years – their demise, resulting in much less pollination, poses a serious threat to numerous crops, and thus the food supply. There is a similar disappearance of frogs internationally, signaling ecological problems, among them fungal infections. This book aims to fill this void by describing and discussing what is known about non-human immunology. It covers various major animal phyla, its chapters organized in a progression from the simplest unicellular organisms to the most complex vertebrates, mammals. Chapters are written by experts, covering the latest findings and new research being conducted about each phylum. Edwin L. Cooper is a Distinguished Professor in the Laboratory of Comparative Immunology, Department of Neurobiology at UCLA’s David Geffen School of Medicine.

The activities of modern society have unleashed a range of toxic chemicals into the global environment. Many of these toxicants are now being detected in increasing quantities in the tissues of marine mammals, most notably in top predators who acquire relatively large amounts of toxic chemicals by ingesting contaminated prey. Toxicology of M

Continuing the tradition set by the first and second editions, each a bestseller in its own right, the third edition of Immunotoxicology and Immunopharmacology provides reviews of environmental agents, updated to reflect the latest information on how these agents influence immune system function and health. For the first time in the book's history, an entire section covers the phylogeny and ontogeny of the immune system, spanning levels of biological complexity from earthworms to marine mammals.

The highly specialized nature of marine mammals when compared with their terrestrial counterparts, the environment in which they live, and the impact of humans on them throughout history and at the present, have made of the scholarship on these creatures something unique in itself. Therefore, it is not surprising that many researchers have also taken a distinctive approach to their study. This volume is aimed at providing a glimpse at such diversity of views and approaches while delivering valuable information on marine mammalogy. Given the increasing concerns regarding issues of anthropogenic factors affecting these animals, it is not surprising that the majority of chapters in this book deal with this subject.

AAP Prose Award Finalist 2018/19 For three decades, this book has been acknowledged as the most respected scientific reference specifically devoted to marine mammal medicine and health. Written by approximately 100 contributors who are recognized globally as leaders in their respective fields, the CRC Handbook of Marine Mammal Medicine, Third Edition continues to serve as the essential guide for all practitioners involved with marine mammals including veterinarians, technicians, biological researchers, students, managers, keepers, curators, and trainers. The 45 chapters provide essential information for the practitioner on pathology, infectious diseases, medical treatment, anesthesia, surgery, husbandry, health assessment, species-specific medicine, medically pertinent anatomy and physiology, and global health concerns such as strandings, oil spills, and entanglements of marine mammals. Covers all aspects of marine mammal veterinary practice Written by internationally acknowledged experts Adds new chapters on Ophthalmology, Dentistry, Ethics, Oil Spill Response, Health Assessments, Whale Entanglement Response, Dive Response, and Biotoxins Richly illustrated in color throughout the new edition including updated anatomical drawings and extensive photographs of ocular lesions Provides guidance to websites that regularly present updated information and images pertinent to current marine mammal medicine such as imaging and stranding network contacts Discusses ethics and animal welfare. The book guides the reader through the veterinary care of cetaceans, pinnipeds, manatees, sea otters, and polar bears. In addition to summaries of current knowledge, chapters provide information on those digital resources and websites which present the latest information as it emerges in the field. The CRC Handbook of Marine Mammal Medicine, Third Edition gives a call to action for scientists to experiment with new endeavors to engage and inspire current and future generations to care for marine mammals and the marine environment, and work together to find solutions. As the most trusted reference for marine mammal conservation medicine and for marine mammal medical facilities around the world, this book needs to be in your library.