Composite Tissue Allograft

The first textbook of its kind dealing with composite tissue allograft and allograft transplantation, provides an excellent overview on the subject. It provides a clear description of the current status of the transplant of every composite tissue allograft already performed and others which are still at the basic experimental level.The editors of the book, who also contribute chapters in their expertise, are world renowned surgeons. This book opens with an introductory chapter on the history of this type of transplantation and then details the clinical experience in each graft such as hand, larynx, face, uterus and the related histopathology, immunosuppression and immunomodulation.A multidisciplinary and comprehensive presentation of the various aspects of this new area of transplantation will allow the reader to understand the complexity and the challenges of composite tissue transplantation. A number of important topics are analyzed and discussed in detail, such as the ethical, medicolegal, psychological and immunological implications. New rehabilitation techniques and strategies, together with innovative tools for the functional evaluation of the transplanted parts, are highlighted. A section on the experimental work underlines what lies ahead of us./a

This brilliant synthesis summarizes all of the recent accomplishments – as well as the ongoing research – in the field of composite tissue transplantation. It includes sections on hand transplantation and vascularized bone marrow transplantation. The volume focuses on immunology and the biotechnology/bioengineering aspects of transplantation surgery, as those two areas have demonstrated the most growth within the last five years in terms of current research.

Transplanting hands -- a model of composite tissue grafting -- began in Lyons in November 1998 with the transplant of one hand and then, in January 2000, of two, both with the support of the Mérieux Foundation. Advances in immunosuppression made possible some unusual transplants of tissue, such as bones, knee-joints, femurs and larynx. From these stemmed the first attempts to transplant hands. This book looks at the long-term results of reattaching hands that have been accidentally amputated. It reviews all the problems -- technical, immunological, nervous, functional and psychological -- that surgeons encountered during and after the transplants. Surgeons, transplant experts, immunologists, dermatologists, psychiatrists, neurophysiologists, physiotherapists and re-education experts will also find here answers to their ethical and legal questions about removing tissue from donors, as well as information about composite tissue grafts in plastic and reconstructive surgery.

This unique publication was written by experts who have made significant contributions to the development of reconstructive microsurgery and vascularized composite allotransplantation and are likely to shape its future. The book is divided into three major sections. The first presents the state-of-the-art of autologous microsurgical reconstruction. It summarizes current achievements, highlights the shortcomings of currently available techniques, and prepares the reader for the next evolutionary step: allotransplantation. Section two is a comprehensive review of allotransplantation, from immunology to surgical techniques. Finally, for those interested in establishing a comprehensive center for vascularized composite allotransplantation, section three provides important lessons from the successful Chang Gung Vascularized Composite Allotransplantation Center. From Auto- to Allotransplantation is indeed the only up-to-date and complete reference available on the topic. Scholars and research fellows interested in transplantation will benefit greatly from this work. It is also an invaluable resource for plastic, orthopedic, hand, ENT, oromaxillofacial, and general surgeons as well as for residents.

This book presents international experimental and clinical experience on limb transplantation and other composite tissue allografts, representing the most complete and comprehensive review of this innovative and ground breaking procedure. This book is a milestone in medical literature and an asset for every scientific library.

This book summarizes rapid progress and innovation in transplantation and regenerative medicine - the merger of reconstructive plastic surgery and transplantation - called Vascularized Composite Allotransplantation. This merger includes face, hand, uteri, larynx, tongue, penis and trachea translplantations as well as other body part transplants using grafts derived from organ donors. These sorts of transplants are now performed more commonly. Cell therapies for immunomodulation are surrogates for immune responses after transplantation to non-invasive imaging of neuroregeneration for improving functional outcomes after transplant.

A definitive summary of novel techniques, this volume details the most current and multidisciplinary approach to new technologies used in general plastic surgery, hand surgery, peripheral nerve surgery, microsurgery, breast surgery, esthetic surgery, and trauma surgery. It also gives an overview of the most important and clinically relevant plastic surgery research. The aim is to stimulate the reader to look at future advances and applications of research and their relevance to daily clinical practice in plastic surgery. Appropriate for different sub-specialties not only in plastic surgery (breast, face, esthetic, hand, microsurgery chapters) but also in orthopedics (hand, microsurgery, nerve chapters) and neurosurgery (peripheral nerve chapter), this book will also be of great interest to trainee surgeons.