Controlled Release

The concept of controlled release has attracted increasing attention over the last two decades, with the applications of this technology proliferating in diverse fields in cluding medicine, agriculture and biotechnology. Research and developmental efforts related to controlled release are multiplying in both industry and academia. The reason for this phenomenal growth is obvious. The use of a variety of biologically active agents, such as drugs, fertilizers and pesticides, has become an integral part of modern society. Along with the use of these reagents has evolved an awareness that their uncontrolled application almost inevitably induces harmful effects on the health of humans and their surrounding environments. To eliminate or minimize these harmful effects necessitates the controlled release of these chemicals. Moreover, the controlled release of substances, not usually considered toxic or hazardous, e.g., some catalysts and nutrients, can enhance their effectiveness. The number and variety of controlled release systems, differing in their physical and chemical makeup, are increasing rapidly. Proliferation almost always demands correlation, generalization and unification; it requires both the development of underlying theories of their behavior and the mechanistic interpretation of their performance. This, in turn, requires a statistical and mathematical (quantitative) treatment of the scientific information and technical data pertaining to them. A quantitative treatment can also facilitate the formulation of procedures for computer-aided design of these systems through a priori prediction of their per formance for a variety of design parameters.

This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and regulatory issues.

This book approaches the subject from a mechanistic perspective that pitches the language at a level that is understandable to those entering the field and who are not familiar with its common phrases or complex terms. It provides a simple encapsulation of concepts and expands on them. In each chapter the basic concept is explained as simply and clearly as possible without a great deal of detail, then in subsequent sections additional material, exceptions to the general rule, examples, etc., is introduced and built up. Such material was generously supplemented with diagrams; conceptually elegant line diagrams in two or three colors. The artwork was well thought out and able to condense the scientific principles into a novel and visually exciting form. The diagrams encourage browsing or draw the reader to salient points. In addition, the technique of highlighting key concepts in a separate box is used throughout each chapter.

The Handbook of Pharmaceutical Controlled Release Technology reviews the design, fabrication, methodology, administration, and classifications of various drug delivery systems, including matrices, and membrane controlled reservoir, bioerodible, and pendant chain systems. Contains cutting-edge research on the controlled delivery of biomolecules!

Given the rapid development and use of biomaterials, it is becoming increasingly important to understand the structure, processing and properties of biomedical polymers and their medical applications. With its distinguished editor and team of international contributors, Biomedical Polymers reviews the latest research on this important group of biomaterials. The book discusses natural, synthetic, biodegradable and non bio-degradable polymers and their applications. Chapters review polymeric scaffolds for tissue engineering and drug delivery systems, the use of polymers in cell encapsulation, their role as replacement materials for heart valves and arteries, and their applications in joint replacement. The book also discusses the use of polymers in biosensor applications. Biomedical polymers is an essential reference for scientists and all those concerned with the development and use of this important group of biomaterials Reviews the latest research in this important group of biomaterials Discusses natural, synthetic, biodegradable and non-biodegradable polymers and their applications Examines the use of biomedical polymers in such areas as drug delivery systems and cell encapsulation

The emergence of the discipline of encapsulation and controlled release has had a great impact on the food and dietary supplements sectors; principally around fortifying food systems with nutrients and health-promoting ingredients. The successful incorporation of these actives in food formulations depends on preserving their stability and bioavailability as well as masking undesirable flavors throughout processing, shelf life and consumption. This second edition of Encapsulation and Controlled Release Technologies in Food Systems serves as an improvement and a complement companion to the first. However, it differentiates itself in two main aspects. Firstly, it introduces the reader to novel encapsulation and controlled release technologies which have not yet been addressed by any existing book on this matter, and secondly, it offers an in-depth discussion on the impact of encapsulation and controlled release technologies on the bioavailability of health ingredients and other actives. In common with the first edition the book includes chapters written by distinguished authors and researchers in their respective areas of specialization. This book is designed as a reference for scientists and formulators in the food, nutraceuticals and consumer products industries who are looking to formulate new or existing products using microencapsulated ingredients. It is also a post-graduate text designed to provide students with an introduction to encapsulation and controlled release along with detailed coverage of various encapsulation technologies and their adaptability to specific applications.

Controlled Release of Bioactive Materials is a collection papers that deal with the study of controlled release applications in drugs and other pharmacological products and processes. The text covers topics such as the theory and practice of controlled drug delivery from bioerodible polymers, biodegradable drug delivery systems from aliphatic polyesters, and the applications of osmotic drug delivery. Also covered are topics such as the application of polymers for the sustained release of macromolecules, controlled transdermal delivery, and the use of hydrogel devices for the controlled release of steroid hormones. The book is recommended for pharmacologists and doctors who would like to know more about advancements in the field of controlled release applications and its uses in healthcare, especially in pharmacology.