Cross Over

It all began at the turn of the century. It was the year 1900 when a young and courageous Michael Guardi left his home in San Giovanni, Naples, to come to America. Within five years, he was joined by his wife, Bella, and their three children, Alfredo, Giovanni, and Chiara. This is the story of three generations of Guardis and the effects that Michael and Bella's uprooting had on their lives. The central character, Americo--more familiarly known as Rico--is portrayed as the victim of what went wrong in his life because of the choices of others and what went wrong because of his own.

Developing a model-based approach that enables any cross-over trial, of any degree of imbalance, to be analyzed both for direct effects and for residual effects, using consistent procedures that employ commercially available statistical software, this text offers a guide to the analysis of cross-over designs.;Illustrating practical applications throughout with examples, this book: emphasizes the importance of choosing highly efficient designs that separate treatment and carryover effects; demonstrates the exact methodology needed to handle the analysis of data; presents a new methodology for the analysis of binary and categorical data; and considers the effects of blocking. The appendices facilitate the choosing of an appropriate design for every experimental need.

An introduction to state-of-the-art experimental design approaches to better understand and interpret repeated measurement data in cross-over designs. Repeated Measurements and Cross-Over Designs: Features the close tie between the design, analysis, and presentation of results Presents principles and rules that apply very generally to most areas of research, such as clinical trials, agricultural investigations, industrial procedures, quality control procedures, and epidemiological studies Includes many practical examples, such as PK/PD studies in the pharmaceutical industry, k-sample and one sample repeated measurement designs for psychological studies, and residual effects of different treatments in controlling conditions such as asthma, blood pressure, and diabetes. Utilizes SAS(R) software to draw necessary inferences. All SAS output and data sets are available via the book's related website. This book is ideal for a broad audience including statisticians in pre-clinical research, researchers in psychology, sociology, politics, marketing, and engineering.

A comprehensive and practical resource for analyses of crossover designs For ethical reasons, it is vital to keep the number of patients in a clinical trial as low as possible. As evidenced by extensive research publications, crossover design can be a useful and powerful tool to reduce the number of patients needed for a parallel group design in studying treatments for non-curable chronic diseases. This book introduces commonly-used and well-established statistical tests and estimators in epidemiology that can easily be applied to hypothesis testing and estimation of the relative treatment effect for various types of data scale in crossover designs. Models with distribution-free random effects are assumed and hence most approaches considered here are semi-parametric. The book provides clinicians and biostatisticians with the exact test procedures and exact interval estimators, which are applicable even when the number of patients in a crossover trial is small. Systematic discussion on sample size determination is also included, which will be a valuable resource for researchers involved in crossover trial design. Key features: Provides exact test procedures and interval estimators, which are especially of use in small-sample cases. Presents most test procedures and interval estimators in closed-forms, enabling readers to calculate them by use of a pocket calculator or commonly-used statistical packages. Each chapter is self-contained, allowing the book to be used a reference resource. Uses real-life examples to illustrate the practical use of test procedures and estimators Provides extensive exercises to help readers appreciate the underlying theory, learn other relevant test procedures and understand how to calculate the required sample size. Crossover Designs: Testing, Estimation and Sample Size will be a useful resource for researchers from biostatistics, as well as pharmaceutical and clinical sciences. It can also be used as a textbook or reference for graduate students studying clinical experiments.

As society becomes more culturally diverse and globally connected, churches and seminaries are rapidly changing. And as the church changes, preaching must change too. Crossover Preaching proposes a way forward through conversation with the "dean of the nation?s black preachers," Gardner C. Taylor, senior pastor emeritus of Concord Baptist Church in Brooklyn, New York. In this richly interdisciplinary study, Jared E. Alcántara argues that an analysis of Taylor?s preaching reveals an improvisational-intercultural approach that recovers his contemporary significance and equips U. S. churches and seminary classrooms for the future. Alcántara argues that preachers and homileticians need to develop intercultural and improvisational proficiencies to reach an increasingly intercultural church. Crossover Preaching equips them with concrete practices designed to help them cultivate these competencies and thus communicate effectively in a changing world.

Is an urban based approach to mission still relevant in a networked global society? If so, what is particular about the urban context for the heart of God's mission? How is that mission understood in terms of evangelism and proclamation; sin and salvation; the work of the sacraments and the Holy Spirit; and challenge of Christ in the lives of his followers? Theological reflection, case studies and new insights come together as practitioners, theologians and urban clergy reflect on the presence of the Church in urban communities. Crossover City confronts the theological priorities of the Church as it attempts to hold the tensions between expectations of its partnership in social regeneration and welfare and its prophetic voice through its continued and transformative presence in marginalized communities. It challenges the way theology is often done in isolated factions that deny openness and collaboration which must underpin the transformative mission our urban areas cry out for. Critical reading for those in theological training and parish ministry seeking resources for a creative and radical witness in our increasingly urban world.