Current Advances In Biotechnological Production Of Xylitol

This book explores recent advances in the microbial production of xylitol and its applications in food and medical sector. Xylitol is an important biomolecule from lignocellulose biorefinery which is produced from the xylose by chemical reactions or microbial fermentation methods. Currently, the demand of xylitol at commercial scale is being met through chemical methods. However, recent breakthroughs made in plant cell wall destruction, genetic engineering to develop the designer microorganisms, fermentation methods and media formulations and downstream processing have led the ways for sustainable production of xylitol at commercial scale in lignocellulose biorefineries. Microbial production of xylitol is preferred over the chemical processes as it is environmentally friendly, higher process efficiency with the desired product yield, and product recovery with minimum impurities. This book is a unique compilation of 11 book chapters written by experts in their respective fields. These chapters present critical insights and discuss the current progress and future progress in this area into fermentative xylitol production. Chapter 9 is licensed under the terms of the Creative Commons Attribution 4.0 International License. For further details see license information in the chapter.

Commercially, D-xylitol is produced by chemical reactions that are tailored to the requirements of various sectors. However, due to the rising interest in sustainable development and ecologically benign practices, microbial transformation processes are generally preferred over the conventional chemical conversion process. The former have multiple advantages, including less chemical load on the environment, higher efficiency, and the ability to dilute multiple downstream transformation attempts while maintaining product yield and recovery. This book aims to disseminate the most current advances in the biotechnological production of D-xylitol and its applications in medical and health care. It is a unique collection of 15 book chapters split into 5 sections and written by experts in their respective fields, who present critical insights into several topics, review current research, and discuss future progress in this area. This book also provides essential information on hemicellulose hydrolysis to recover D-xylose, detoxification of hemicellulose hydrolysates, and improved fermentation methods for increased D-xylitol production. The highlights of strain improvement to increase the D-xylitol titers and downstream recovery of D-xylitol are also discussed in several sections. The current applications of D-xylitol in medical and health care have been used to justify the cost incurred for setting up the demonstration plant for D-xylitol production in the market. Apart from researchers and post-graduate students in the field of microbial biotechnology, this book will assist those in the business community who deal with the economic analysis of bio-based products and their marketing.

This book provides state-of-the-art reviews, the latest research, prospects and challenges of the production of platform chemicals such as C6 sugars, 5-hydroxymethylfurfural, furfural, gamma-valerolactone, xylitol, 2,5-furandicarboxylic acid, levulinic acid, ethanol and others from sustainable biomass resources using processes that include heterogeneous catalysis, ionic liquids, hydrothermal/solvothermal, electrochemical and fermentation methods. It also discusses the application of these chemicals and their derivatives for synthesizing commodity chemicals via various routes. Intended as a reference resource for researchers, academicians and industrialists in the area of energy, chemical engineering and biomass conversion, it provides a wealth of information essential for assessing the production and application of various biomass-derived platform chemicals using biological, chemical and electrochemical techniques.

This book offers the latest scientific research on applied microbiology presented at the IV International Conference on Environmental, Industrial and Applied Microbiology (BioMicroWorld2011) held in Spain in 2011. A wide-ranging set of topics including agriculture, environmental, food, industrial and medical microbiology makes this book interesting not only for microbiologists, but also for anyone who likes to keep up with cutting-edge research in microbiology and microbial biotechnology. Readers will find a major collection of knowledge, approaches, methods and discussions on the latest advances and challenges in applied microbiology in a compilation of 136 chapters written by active researchers in the field from around the world. The topics covered in this single volume include biodegradation of pollutants, water, soil and plant microorganisms, biosurfactants, antimicrobial natural products, antimicrobial susceptibility, antimicrobial resistance, human pathogens, food microorganisms, fermentation, biotechnologically relevant enzymes and proteins, microbial physiology, metabolism and gene expression mainly, although many other subjects are also discussed. Sample Chapter(s) A microcosm study on the die-off response of the indicator bacteria, Enterococcus faecium and Enterococcus faecalis (267 KB) Contents:Agriculture, Soil, Environmental and Marine–Aquatic MicrobiologyFood MicrobiologyIndustrial Microbiology. Methods. Quantitative Models and BioinformaticsMedical and Pharmaceutical Microbiology. Antimicrobial Agents and ChemotherapyMicrobial Physiology, Metabolism and Gene ExpressionBiotechnologically Relevant Enzymes and Proteins Readership: Professionals, microbiologists, clinicians, (bio)chemists, physicists, and engineers. Keywords:Microorganisms;Applied Microbiology;Environmental Microbiology;Industrial Microbiology;Microbial Biotechnology;BioMicroWorld2011 Conference Proceedings Book;Mendez-VilasKey Features:The topics covered in this single volume include biodegradation of pollutants, water, soil and plant microorganisms, biosurfactants, antimicrobial natural products, antimicrobial susceptibility, antimicrobial resistance, human pathogens, food microorganisms, fermentation, biotechnologically relevant enzymes and proteins, microbial physiology, metabolism and gene expression mainly, although many other subjects are also discussed

Biomass Fractionation Technologies for a Lignocellulosic Feedstock-based Biorefinery reviews the extensive research and tremendous scientific and technological developments that have occurred in the area of biorefinering, including industrial processes and product development using ‘green technologies’, often referred as white biotechnology. As there is a huge need for new design concepts for modern biorefineries as an alternative and amendment to industrial crude oil and gas refineries, this book presents the most important topics related to biomass fractionation, including advances, challenges, and perspectives, all with references to current literature for further study. Presented in 26 chapters by international field specialists, each chapter consists of review text that comprises the most recent advances, challenges, and perspectives for each fractionation technique. The book is an indispensable reference for all professionals, students, and workers involved in biomass biorefinery, assisting them in establishing efficient and economically viable process technologies for biomass fractionation. Provides information on the most advanced and innovative pretreatment processes and technologies for biomass Reviews numerous valuable products from lignocellulose Discusses integration of processes for complete biomass conversion with minimum waste generation Identifies the research gaps in scale-up Presents an indispensable reference for all professionals, students, and workers involved in biomass biorefinery, assisting them in establishing efficient and economically viable process technologies for biomass fractionation

White biotechnology is industrial biotechnology dealing with various biotech products through applications of microbes. The main application of white biotechnology is commercial production of various useful organic substances, such as acetic acid, citric acid, acetone, glycerine, etc., and antibiotics like penicillin, streptomycin, mitomycin, etc., and value added product through the use of microorganisms especially fungi and bacteria. The value-added products included bioactive compounds, secondary metabolites, pigments and industrially important enzymes for potential applications in agriculture, pharmaceuticals, medicine and allied sectors for human welfare. In the 21st century, techniques were developed to harness fungi to protect human health (through antibiotics, antimicrobial, immunosuppressive agents, value-added products etc.), which led to industrial scale production of enzymes, alkaloids, detergents, acids, biosurfactants. The first large-scale industrial applications of modern biotechnology have been made in the areas of food and animal feed production (agricultural/green biotechnology) and pharmaceuticals (medical/red biotechnology). In contrast, the production of bio-active compounds through fermentation or enzymatic conversion is known industrial or white biotechnology. The beneficial fungal strains may play important role in agriculture, industry and the medical sectors. The beneficial fungi play a significance role in plant growth promotion, and soil fertility using both, direct (solubilization of phosphorus, potassium and zinc; production of indole acetic acid, gibberellic acid, cytokinin and siderophores) and indirect (production of hydrolytic enzymes, siderophores, ammonia, hydrogen cyanides and antibiotics) mechanisms of plant growth promotion for sustainable agriculture. The fungal strains and their products (enzymes, bio-active compounds and secondary metabolites) are very useful for industry. The discovery of antibiotics is a milestone in the development of white biotechnology. Since then, white biotechnology has steadily developed and now plays a key role in several industrial sectors, providing both high valued nutraceuticals and pharmaceutical products. The fungal strains and bio-active compounds also play important role in the environmental cleaning. This volume covers the latest research developments related to value-added products in white biotechnology through fungi.

Biotechnological Production of Bioactive Compounds provides insights on the most recent innovations, trends, concerns, solutions and practical challenges encountered in the fields of enzyme technology and nanobiotechnology for the production of bioactive materials with extra health benefits. As nanobiotechnology has improved the bioactive extraction process significantly, many bioactives, including bioflavonoids, omega-3 fatty acids, biopigments and low calorie sugar substitutes are a pivotal part of the food industry. The book highlights the production of extra health benefits “bioactives’’ from plants and microbes and explains how the extraction efficiency of bioactives molecules improves significantly with the recent advances in nanobiotechnology. Researchers in the fields of biochemical engineering, biotechnology, bioremediation, environmental sustainability and those in pharma industries will find the information in this book very helpful and illuminating. Outlines technological advances in bioactives extraction Covers bioflavonoids, biopigments, omega-3-fatty acids and low sugar substitutes Explains the mechanisms of Green cargo (biogenic nanoparticles) for the delivery of bioactive molecules

This book contains a compilation of papers presented at the II International Conference on Environmental, Industrial and Applied Microbiology (BioMicroWorld2007) held in Seville, Spain on 28 November 1 December 2007, where over 550 researchers from about 60 countries attended and presented their cutting-edge research. The main goals of this book are to: (1) identify new approaches and research opportunities in applied microbiology, presenting works that link microbiology with research areas usually related to other scientific and engineering disciplines; and (2) communicate current research priorities and progress in the field. The contents of this book mirror this focus. Microbiologists interested in environmental, industrial and applied microbiology and, in general, scientists whose research fields are related to applied microbiology can find an overview of the current state of the art in the topic. In addition to the more general topic, some chapters are devoted to specific branches of microbiology research, such as bioremediation; biosurfactants; microbial factories; biotechnologically relevant enzymes and proteins; microbial physiology, metabolism and gene expression; and future bioindustries.