Current Advances In Drug Delivery Through Fast Dissolving Disintegrating Dosage Forms
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Current Advances in Drug Delivery Through Fast Dissolving Disintegrating Dosage Forms
Author | : Vikas Anand Saharan |
Publsiher | : Bentham Science Publishers |
Total Pages | : 453 |
Release | : 2017-05-11 |
Genre | : Medical |
ISBN | : 9781681084596 |
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Fast Dissolving/Disintegrating Dosage Forms (FDDFs) have been commercially available since the late 1990s. FDDFs were initially available as orodispersible tablets, and later, as orodipsersible films for treating specific populations (pediatrics, geriatrics, and psychiatric patients). Granules, pellets and mini tablets are among latest additions to these dosage forms, which are still in the development pipeline. As drug delivery systems, FDDFs enable quicker onset of action, immediate drug delivery, and sometimes offer bioavailability benefits due to buccal/sublingual absorption. With time, FDDF have evolved to deliver drugs in a sustained and controlled manner. Their current market and application is increasing in demands with advances in age adapted dosage forms for different patients and changing regulatory requirements that warrant mandatory assessments of new drugs and drug products before commercial availability. This book presents detailed information about FDDFs from their inception to recent developments. Readers will learn about the technical details of various FDDF manufacturing methods, formulation aspects, evaluation and methods to conduct clinical studies. The authors also give examples of marketed fast disintegrating/dissolving drug products in US, Europe, Japan, and India. This reference is ideal for pharmacology students at all levels seeking information about this specific form of drug delivery and formulation.
Drug Delivery Research Advances
Author | : Boris O. Mashkevich |
Publsiher | : Nova Publishers |
Total Pages | : 274 |
Release | : 2007 |
Genre | : Medical |
ISBN | : 160021732X |
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Drug delivery is a term that refers to the delivery of a pharmaceutical compound to humans or animals. Most common methods of delivery include the preferred non-invasive oral (through the mouth), nasal, pneumonial (inhalation), and rectal routes. Many medications, however, can not be delivered using these routes because they might be susceptible to degradation or are not incorporated efficiently. For this reason many protein and peptide drugs have to be delivered by injection. For example, many immunisations are based on the delivery of protein drugs and are often done by injection. Current efforts in the area of drug delivery include the development of targeted delivery in which the drug is only active in the target area of the body (for example, in cancerous tissues) and sustained release formulations in which the drug is released over a period of time in a controlled manner from a formulation. This new book focuses on worldwide research on drug delivery and targeting at the molecular, cellular, and higher levels.
Recent Advances in Drug Delivery Systems
Author | : James M Anderson |
Publsiher | : Unknown |
Total Pages | : 408 |
Release | : 1984-05-31 |
Genre | : Electronic Book |
ISBN | : 1461327466 |
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Biopolymers In Drug Delivery Recent Advances and Challenges
Author | : Michael U. Adikwu,Charles O. Esimone |
Publsiher | : Bentham Science Publishers |
Total Pages | : 232 |
Release | : 2010-05-13 |
Genre | : Biopolymers |
ISBN | : 9781608050789 |
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"This Ebook describes the applicability of diverse natural and synthetic biopolymers and their blends in drugs, vaccines and gene delivery. It would serve as a concise body of information on biopolymers for researchers, industries and students of pharmaceu"
Drug Delivery to the Oral Cavity
Author | : Tapash K. Ghosh,William R. Pfister |
Publsiher | : CRC Press |
Total Pages | : 448 |
Release | : 2005-02-28 |
Genre | : Medical |
ISBN | : 0824782933 |
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With contributions from recognized authorities in industry, academia, and government, this reference presents the state-of-the-art in the testing, formulation, and clinical evaluation of intraoral drug delivery products-summarizing intraoral dosage forms in various stages of research, as well as products currently on the market.
Hot Melt Extrusion
Author | : Dennis Douroumis |
Publsiher | : John Wiley & Sons |
Total Pages | : 404 |
Release | : 2012-04-24 |
Genre | : Science |
ISBN | : 9781118307878 |
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Hot-melt extrusion (HME) - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and drug delivery systems, for example granules and sustained release tablets. Hot-Melt Extrusion: Pharmaceutical Applications covers the main instrumentation, operation principles and theoretical background of HME. It then focuses on HME drug delivery systems, dosage forms and clinical studies (including pharmacokinetics and bioavailability) of HME products. Finally, the book includes some recent and novel HME applications, scale -up considerations and regulatory issues. Topics covered include: principles and die design of single screw extrusion twin screw extrusion techniques and practices in the laboratory and on production scale HME developments for the pharmaceutical industry solubility parameters for prediction of drug/polymer miscibility in HME formulations the influence of plasticizers in HME applications of polymethacrylate polymers in HME HME of ethylcellulose, hypromellose, and polyethylene oxide bioadhesion properties of polymeric films produced by HME taste masking using HME clinical studies, bioavailability and pharmacokinetics of HME products injection moulding and HME processing for pharmaceutical materials laminar dispersive & distributive mixing with dissolution and applications to HME technological considerations related to scale-up of HME processes devices and implant systems by HME an FDA perspective on HME product and process understanding improved process understanding and control of an HME process with near-infrared spectroscopy Hot-Melt Extrusion: Pharmaceutical Applications is an essential multidisciplinary guide to the emerging pharmaceutical uses of this processing technology for researchers in academia and industry working in drug formulation and delivery, pharmaceutical engineering and processing, and polymers and materials science. This is the first book from our brand new series Advances in Pharmaceutical Technology. Find out more about the series here.
Pharmaceutics
Author | : Michael E. Aulton |
Publsiher | : Unknown |
Total Pages | : 679 |
Release | : 2002 |
Genre | : Medical |
ISBN | : 0443055173 |
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A comprehensive textbook covering the design of dosage forms and all aspects of drug delivery systems. 'Pharmaceutics' in its broadest sense is the 'art of the apothecary' or, in simple terms, pharmaceutical preparations. It remains a diverse subject in the pharmacy curriculum, encompassing design of drugs, their manufacture, and the elimination of micro-organisms from the products. This books encompasses all those areas and pays particular attention to the design of dosage forms and their manufacture.
Oral Mucosal Drug Delivery and Therapy
Author | : Michael J. Rathbone,Sevda Senel,Indiran Pather |
Publsiher | : Springer |
Total Pages | : 279 |
Release | : 2015-03-13 |
Genre | : Medical |
ISBN | : 9781489975584 |
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This volume provides a comprehensive overview of the current issues facing scientists working on delivering drugs locally and systemically via the membranes that line the mouth. The book describes the anatomical and physiological challenges of this route for drug delivery and how they impact the design of oral mucosal drug delivery systems. It also provides a detailed description of current oral mucosal drug delivery technologies that overcome these challenges alongside research, development and assessment methods. In 11 authoritative chapters, the book affords an in-depth evaluation of the major issues associated with this route of administration, namely the retention of the drug/product at the site of administration and increasing drug permeability through the oral mucosa. The book provides insights into the in vitro and in vivo methods available to assess drug permeability and retention, offers solutions on how to improve the permeation of the drugs through the oral mucosa, and explores approaches to prolong drug/product retention at the site of administration. It also indicates future directions in research and product development. Oral Mucosal Drug Delivery and Therapy is a key resource for those wishing to extend their knowledge of this field.