Cystic Fibrosis An Issue Of Clinics In Chest Medicine E Book

Dr. Jon Koff has assembled and expert team of authors of the topic of Cystic Fibrosis. Articles include: Epidemiology and Pathobiology, Genetics and genetic medicine in Cystic Fibrosis, Innate and Adaptive Immunity in Cystic Fibrosis, Microbiome in Cystic Fibrosis, Diagnostic Testing in Cystic Fibrosis, Treating Pseudomonas in Cystic Fibrosis, Diagnosis of Adult Patients with Cystic Fibrosis, Transition from Pediatrics to Adult Care, Lung Transplant in Cystic Fibrosis, and more!

In this issue of Clinics in Chest Medicine, guest editors Drs. Clemente J. Britto and Jennifer L. Taylor-Cousar bring their considerable expertise to Advances in Cystic Fibrosis. Top experts in the field cover key topics such as genetics of cystic fibrosis (CF): clinical implications; innate and adaptive immunity in CF; novel applications of biomarkers and personalized medicine to define the spectrum of CF; emerging approaches to understand CF pathogenesis; and more. Contains 18 relevant, practice-oriented topics including novel approaches to multidrug resistant infections in CF; clinical outcomes of highly-effective modulator therapy; nontuberculous mycobacterial infections in CF; management of mental health in CF; sexual and reproductive health in CF; nutritional management in CF; transitions of care in CF; and more. Provides in-depth clinical reviews on advances in cystic fibrosis, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Cystic Fibrosis (CF) is a multisystem disease whose symptoms and signs involve the gastrointestinal tract (thus affecting nutritional status), endocrine system, reproductive system and the respiratory tract (nose, sinuses and lungs). Despite new treatments, the median survival for patients with CF is less than optimal, primarily due to complications of obstructive lung disease. Currently there are approximately 60,000-80,000 people worldwide with CF. The clinical manifestations of CF are caused by dysfunction of CFTR (cystic fibrosis transmembrane conductance regulator), a multifunctional cyclic-AMP regulated ion channel protein. Over time, there has been dramatic improvement in CF patient life expectancy, in large part related to earlier diagnosis (newborn screening), better understanding of molecular genetics and underlying pathophysiology, the integrated and highly specialized Cystic Fibrosis Foundation Accredited Care Centers, and development of a wide range of new treatments and therapies, some of which target the basic CFTR defect. This edition of Pediatric Clinics of North America will offer general pediatricians and family physicians, as well as subspecialists, an update of the extraordinary progress made in the understanding and treatment of Cystic Fibrosis.

In this issue of Clinics in Chest Medicine, Guest Editors Harold R Collard, Luca Richeldi, and Kerri A. Johannson bring their considerable expertise to the topic of Next-generation Interstitial Lung Disease. Provides concise and comprehensive coverage of the issues physicians face every day. Presents the latest information on a timely, focused topic under the leadership of experienced editors in the field.

In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

This issue of Clinics in Chest Medicine, guest-edited by Dr. Margaret Pisani, is focused on Gender and Respiratory Disease. Topics discussed in this issue include but are not limited to: What are sex and gender and how can we study their impact in respiratory disease?, Sex differences in respiratory physiology, Impact of gender on social determinants of health, Gender differences in obstructive sleep apnea, Impact of gender on sleep disorders across the lifespan, Differences between men and women with COPD, Women and Lung Cancer, Pulmonary considerations in pregnant women and Asthma in women-gender specific considerations.

The first issue of Clinics in Chest Medicine to be published with this focus, this issue reviews bronchiectasis from numerous angles to provide comprehensive coverage on this important subject. Epidemiology, airway defense mechanisms, pathogenesis, imaging and genetic causes of bronchiectasis are discussed. Allergic bronchopulmonary aspergillosis is addressed, as well as non-tuberculous mycobacteria as a cause of bronchiectasis. Authors examine how to evaluate the success of therapy for bronchiectasis (what endpoints to use) and then discuss a variety of therapy options: inhaled and systemic antibiotic treatment, chest physiotherapy, pharmacologic agents for mucous clearance, antipinflammatory therapy and macrolides. Pulmonary resection and lung transplantation for bronchiectasis are reviewed. Recent advances in Cystic Fibrosis are also discussed.

In this issue of Clinics in Chest Medicine, guest editors Drs. Clemente J. Britto and Jennifer L. Taylor-Cousar bring their considerable expertise to Advances in Cystic Fibrosis. Top experts in the field cover key topics such as genetics of cystic fibrosis (CF): clinical implications; innate and adaptive immunity in CF; novel applications of biomarkers and personalized medicine to define the spectrum of CF; emerging approaches to understand CF pathogenesis; and more. Contains 18 relevant, practice-oriented topics including novel approaches to multidrug resistant infections in CF; clinical outcomes of highly-effective modulator therapy; nontuberculous mycobacterial infections in CF; management of mental health in CF; sexual and reproductive health in CF; nutritional management in CF; transitions of care in CF; and more. Provides in-depth clinical reviews on advances in cystic fibrosis, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.