Data Mining And Statistical Methods For Knowledge Discovery In Diseases Based On Multimodal Omics

One of the grand challenges in our digital world are the large, complex and often weakly structured data sets, and massive amounts of unstructured information. This “big data” challenge is most evident in biomedical informatics: the trend towards precision medicine has resulted in an explosion in the amount of generated biomedical data sets. Despite the fact that human experts are very good at pattern recognition in dimensions of = 3; most of the data is high-dimensional, which makes manual analysis often impossible and neither the medical doctor nor the biomedical researcher can memorize all these facts. A synergistic combination of methodologies and approaches of two fields offer ideal conditions towards unraveling these problems: Human–Computer Interaction (HCI) and Knowledge Discovery/Data Mining (KDD), with the goal of supporting human capabilities with machine learning./ppThis state-of-the-art survey is an output of the HCI-KDD expert network and features 19 carefully selected and reviewed papers related to seven hot and promising research areas: Area 1: Data Integration, Data Pre-processing and Data Mapping; Area 2: Data Mining Algorithms; Area 3: Graph-based Data Mining; Area 4: Entropy-Based Data Mining; Area 5: Topological Data Mining; Area 6 Data Visualization and Area 7: Privacy, Data Protection, Safety and Security.

This book intends to bring together the most recent advances and applications of data mining research in the promising areas of medicine and biology from around the world. It consists of seventeen chapters, twelve related to medical research and five focused on the biological domain, which describe interesting applications, motivating progress and worthwhile results. We hope that the readers will benefit from this book and consider it as an excellent way to keep pace with the vast and diverse advances of new research efforts.

The advancement of biomedical engineering has enabled the generation of multi-omics data by developing high-throughput technologies, such as next-generation sequencing, mass spectrometry, and microarrays. Large-scale data sets for multiple omics platforms, including genomics, transcriptomics, proteomics, and metabolomics, have become more accessible and cost-effective over time. Integrating multi-omics data has become increasingly important in many research fields, such as bioinformatics, genomics, and systems biology. This integration allows researchers to understand complex interactions between biological molecules and pathways. It enables us to comprehensively understand complex biological systems, leading to new insights into disease mechanisms, drug discovery, and personalized medicine. Still, integrating various heterogeneous data types into a single learning model also comes with challenges. In this regard, learning algorithms have been vital in analyzing and integrating these large-scale heterogeneous data sets into one learning model. This book overviews the latest multi-omics technologies, machine learning techniques for data integration, and multi-omics databases for validation. It covers different types of learning for supervised and unsupervised learning techniques, including standard classifiers, deep learning, tensor factorization, ensemble learning, and clustering, among others. The book categorizes different levels of integrations, ranging from early, middle, or late-stage among multi-view models. The underlying models target different objectives, such as knowledge discovery, pattern recognition, disease-related biomarkers, and validation tools for multi-omics data. Finally, the book emphasizes practical applications and case studies, making it an essential resource for researchers and practitioners looking to apply machine learning to their multi-omics data sets. The book covers data preprocessing, feature selection, and model evaluation, providing readers with a practical guide to implementing machine learning techniques on various multi-omics data sets.

Biologically-inspired data mining has a wide variety of applications in areas such as data clustering, classification, sequential pattern mining, and information extraction in healthcare and bioinformatics. Over the past decade, research materials in this area have dramatically increased, providing clear evidence of the popularity of these techniques. Biologically-Inspired Techniques for Knowledge Discovery and Data Mining exemplifies prestigious research and shares the practices that have allowed these areas to grow and flourish. This essential reference publication highlights contemporary findings in the area of biologically-inspired techniques in data mining domains and their implementation in real-life problems. Providing quality work from established researchers, this publication serves to extend existing knowledge within the research communities of data mining and knowledge discovery, as well as for academicians and students in the field.

This book constitutes the thoroughly refereed post-proceedings of three workshops and an industrial track held in conjunction with the 11th Pacific-Asia Conference on Knowledge Discovery and Data Mining, PAKDD 2007, held in Nanjing, China in May 2007. The 62 revised full papers presented together with an overview article to each workshop were carefully reviewed and selected from 355 submissions.

This book constitutes the refereed proceedings at PAKDD Workshops 2013, affiliated with the 17th Pacific-Asia Conference on Knowledge Discovery and Data Mining (PAKDD) held in Gold Coast, Australia in April 2013. The 47 revised full papers presented were carefully reviewed and selected from 92 submissions. The workshops affiliated with PAKDD 2013 include: Data Mining Applications in Industry and Government (DMApps), Data Analytics for Targeted Healthcare (DANTH), Quality Issues, Measures of Interestingness and Evaluation of Data Mining Models (QIMIE), Biologically Inspired Techniques for Data Mining (BDM), Constraint Discovery and Application (CDA), Cloud Service Discovery (CloudSD).

This book constitutes the thoroughly refereed post-conference proceedings of five international workshops held in conjunction with PAKDD 2011 in Shenzhen, China, in May 2011: the International Workshop on Behavior Informatics (BI 2011), the Workshop on Quality Issues, Measures of Interestingness and Evaluation of Data Mining Models (QIMIE 2011), the Workshop on Biologically Inspired Techniques for Data Mining (BDM 2011), the Workshop on Advances and Issues in Traditional Chinese Medicine Clinical Data Mining (AI-TCM 2011), and the Second Workshop on Data Mining for Healthcare Management (DMGHM 2011). The book also includes papers from the First PAKDD Doctoral Symposium on Data Mining (DSDM 2011). The 42 papers were carefully reviewed and selected from numerous submissions. The papers cover a wide range of topics discussing emerging techniques in the field of knowledge discovery in databases and their application domains extending to previously unexplored areas such as data mining based on optimization techniques from biological behavior of animals and applications in Traditional Chinese Medicine clinical research and health care management.