Defects In Regulation How Where And When The Immune System Can Go Wrong

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

This book explains how stress – either psychological or physical – can activate and/or paralyse human innate or adaptive immunity. Adequate immunity is crucial for maintaining health, both on Earth and in space. During space flight, human physiology is specifically challenged by complex environmental stressors, which are most pronounced during lunar or interplanetary missions. Adopting an interdisciplinary approach, the book identifies the impact of these stressors – the space exposome – on immunity as a result of (dys-)functions of specific cells, organs and organ networks. These conditions (e.g. gravitation changes, radiation, isolation/confinement) affect immunity, but at the same time provide insights that may help to prevent, diagnose and address immune-related health alterations. Written by experts from academia, space agencies and industry, the book is a valuable resource for professionals, researchers and students in the field of medicine, biology and technology. The chapters “The Impact of Everyday Stressors on the Immune System and Health”, “Stress and Radiation Responsiveness” and “Assessment of Radiosensitivity and Biomonitoring of Exposure to Space adiation” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.

How the Immune System Works has helped thousands of students understand what's in their hefty immunology textbooks. In this book, Dr. Sompayrac cuts through the jargon and details to reveal, in simple language, the essence of this complex subject: how the immune system fits together, how it protects us from disease and, perhaps most importantly, why it works the way it does. Featuring Dr. Sompayrac's hallmark lively prose and engaging analogies, How the Immune System Works has been rigorously updated for this sixth edition, including the latest information on subjects such as vaccines, immunological memory, and cancer. A highlight of this edition is a new chapter on immunotherapies – currently one of the hottest topics in immunology. Whether you are completely new to immunology, or require a refresher, How the Immune System Works will provide you with a clear and engaging overview of this fascinating subject.

Regulatory T cells and Autoimmune Diseases addresses recent findings concerning the role of Tregs in the pathogenesis of autoimmune diseases as well as their therapeutic aspects. In particular, this book deals with the various Treg based mechanisms which can lead to autoimmune diseases and covers the different aspects of linking Tregs with autoimmune mechanisms involved in disease development by discussing animal models and human studies. The book specifically focuses on the Treg based therapeutics and their targets to manage all known autoimmune rheumatic, central nervous system, bowel, liver, thyroid, kidney, myopathic, skin, blood & blood vessel, and eye diseases and aims to provide a must-have reference for designing therapeutic strategies to treat these autoimmune diseases. Additionally, the book covers the vaccines induced effects on functioning of Tregs and development of CAR Tregs therapy for these autoimmune diseases and concludes with current challenges and future prospects of Treg-based therapeutics. It is carefully designed to meet the requirements of both basic and advanced researchers in the area and give new dimensions and insight into the regulatory T cells’ role in autoimmune disease pathogenesis and therapeutic aspects. Brings the reader up-to-date on the mechanisms of regulatory T cells (Tregs) in pathogenesis and therapeutics of all autoimmune diseases known to date Provides explicit color illustrations and comprehensible tables for explaining the mechanistic aspects and emerging information in the field Includes human clinical trials and animal model studies for Tregs in diverse autoimmune diseases for the mitigation of the symptoms of autoimmune diseases Offers scientifically applicable and relevant content for readers of various disciplines, including biomedical sciences, medical microbiology/biotechnology, immunology, and medicine