Design Of Experiments And Advanced Statistical Techniques In Clinical Research
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Design of Experiments and Advanced Statistical Techniques in Clinical Research
Author | : Basavarajaiah D. M.,Bhamidipati Narasimha Murthy |
Publsiher | : Springer Nature |
Total Pages | : 380 |
Release | : 2020-11-05 |
Genre | : Medical |
ISBN | : 9789811582103 |
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Recent Statistical techniques are one of the basal evidence for clinical research, a pivotal in handling new clinical research and in evaluating and applying prior research. This book explores various choices of statistical tools and mechanisms, analyses of the associations among different clinical attributes. It uses advanced statistical methods to describe real clinical data sets, when the clinical processes being examined are still in the process. This book also discusses distinct methods for building predictive and probability distribution models in clinical situations and ways to assess the stability of these models and other quantitative conclusions drawn by realistic experimental data sets. Design of experiments and recent posthoc tests have been used in comparing treatment effects and precision of the experimentation. This book also facilitates clinicians towards understanding statistics and enabling them to follow and evaluate the real empirical studies (formulation of randomized control trial) that pledge insight evidence base for clinical practices. This book will be a useful resource for clinicians, postgraduates scholars in medicines, clinical research beginners and academicians to nurture high-level statistical tools with extensive scope.
Statistical Analysis of Designed Experiments Third Edition
Author | : Helge Toutenburg,Shalabh |
Publsiher | : Springer Science & Business Media |
Total Pages | : 625 |
Release | : 2009-12-24 |
Genre | : Mathematics |
ISBN | : 9781441911483 |
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This book is the third revised and updated English edition of the German textbook \Versuchsplanung und Modellwahl" by Helge Toutenburg which was based on more than 15 years experience of lectures on the course \- sign of Experiments" at the University of Munich and interactions with the statisticians from industries and other areas of applied sciences and en- neering. This is a type of resource/ reference book which contains statistical methods used by researchers in applied areas. Because of the diverse ex- ples combined with software demonstrations it is also useful as a textbook in more advanced courses, The applications of design of experiments have seen a signi?cant growth in the last few decades in di?erent areas like industries, pharmaceutical sciences, medical sciences, engineering sciences etc. The second edition of this book received appreciation from academicians, teachers, students and applied statisticians. As a consequence, Springer-Verlag invited Helge Toutenburg to revise it and he invited Shalabh for the third edition of the book. In our experience with students, statisticians from industries and - searchers from other ?elds of experimental sciences, we realized the importance of several topics in the design of experiments which will - crease the utility of this book. Moreover we experienced that these topics are mostly explained only theoretically in most of the available books.
Medical Statistics And Computer Experiments 2nd Edition
Author | : Fang Ji-qian |
Publsiher | : World Scientific |
Total Pages | : 1016 |
Release | : 2014-07-24 |
Genre | : Mathematics |
ISBN | : 9789814566797 |
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This volume consists of three parts: Part I comprises 11 chapters on the basic concepts of statistics, Part II consists of 10 chapters on multivariate statistics and Part III contains 12 chapters on design and analysis for medical research. The book is written using basic concepts and commonly used methods of design and analysis in medical statistics, incorporating the operation of statistical package SAS and 100 computer experiments for the important statistical phenomena related to each chapter. All necessary data, including reference answers for the exercises, SAS programs for all computer experiments and part of the examples, and data documents for 12 medical researches are available. The Chinese version of this book has been recommended as a textbook of statistics for postgraduate program by the Office of Education Research, Ministry of Education, People's Republic of China.
Introduction to Statistical Methods for Clinical Trials
Author | : Thomas D. Cook,David L DeMets |
Publsiher | : CRC Press |
Total Pages | : 465 |
Release | : 2007-11-19 |
Genre | : Mathematics |
ISBN | : 9781584880271 |
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Clinical trials have become essential research tools for evaluating the benefits and risks of new interventions for the treatment and prevention of diseases, from cardiovascular disease to cancer to AIDS. Based on the authors’ collective experiences in this field, Introduction to Statistical Methods for Clinical Trials presents various statistical topics relevant to the design, monitoring, and analysis of a clinical trial. After reviewing the history, ethics, protocol, and regulatory issues of clinical trials, the book provides guidelines for formulating primary and secondary questions and translating clinical questions into statistical ones. It examines designs used in clinical trials, presents methods for determining sample size, and introduces constrained randomization procedures. The authors also discuss how various types of data must be collected to answer key questions in a trial. In addition, they explore common analysis methods, describe statistical methods that determine what an emerging trend represents, and present issues that arise in the analysis of data. The book concludes with suggestions for reporting trial results that are consistent with universal guidelines recommended by medical journals. Developed from a course taught at the University of Wisconsin for the past 25 years, this textbook provides a solid understanding of the statistical approaches used in the design, conduct, and analysis of clinical trials.
Statistical Design Monitoring and Analysis of Clinical Trials
Author | : Weichung Joe Shih,Joseph Aisner |
Publsiher | : CRC Press |
Total Pages | : 405 |
Release | : 2021-10-25 |
Genre | : Medical |
ISBN | : 9781000462753 |
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Statistical Design, Monitoring, and Analysis of Clinical Trials, Second Edition concentrates on the biostatistics component of clinical trials. This new edition is updated throughout and includes five new chapters. Developed from the authors’ courses taught to public health and medical students, residents, and fellows during the past 20 years, the text shows how biostatistics in clinical trials is an integration of many fundamental scientific principles and statistical methods. The book begins with ethical and safety principles, core trial design concepts, the principles and methods of sample size and power calculation, and analysis of covariance and stratified analysis. It then focuses on sequential designs and methods for two-stage Phase II cancer trials to Phase III group sequential trials, covering monitoring safety, futility, and efficacy. The authors also discuss the development of sample size reestimation and adaptive group sequential procedures, phase 2/3 seamless design and trials with predictive biomarkers, exploit multiple testing procedures, and explain the concept of estimand, intercurrent events, and different missing data processes, and describe how to analyze incomplete data by proper multiple imputations. This text reflects the academic research, commercial development, and public health aspects of clinical trials. It gives students and practitioners a multidisciplinary understanding of the concepts and techniques involved in designing, monitoring, and analyzing various types of trials. The book’s balanced set of homework assignments and in-class exercises are appropriate for students and researchers in (bio)statistics, epidemiology, medicine, pharmacy, and public health.
Adaptive Design Methods in Clinical Trials
Author | : Shein-Chung Chow,Mark Chang |
Publsiher | : CRC Press |
Total Pages | : 296 |
Release | : 2006-11-16 |
Genre | : Mathematics |
ISBN | : 9781584887775 |
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Although adaptive design methods are flexible and useful in clinical research, little or no regulatory guidelines are available. One of the first books on the topic, Adaptive Design Methods in Clinical Trials presents the principles and methodologies in adaptive design and analysis that pertain to adaptations made to trial or statistical procedures
Statistical Principles for the Design of Experiments
Author | : R. Mead,S. G. Gilmour,A. Mead |
Publsiher | : Cambridge University Press |
Total Pages | : 135 |
Release | : 2012-09-13 |
Genre | : Mathematics |
ISBN | : 9781139576642 |
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This book is about the statistical principles behind the design of effective experiments and focuses on the practical needs of applied statisticians and experimenters engaged in design, implementation and analysis. Emphasising the logical principles of statistical design, rather than mathematical calculation, the authors demonstrate how all available information can be used to extract the clearest answers to many questions. The principles are illustrated with a wide range of examples drawn from real experiments in medicine, industry, agriculture and many experimental disciplines. Numerous exercises are given to help the reader practise techniques and to appreciate the difference that good design can make to an experimental research project. Based on Roger Mead's excellent Design of Experiments, this new edition is thoroughly revised and updated to include modern methods relevant to applications in industry, engineering and modern biology. It also contains seven new chapters on contemporary topics, including restricted randomisation and fractional replication.
Medical Uses of Statistics
Author | : John C. Bailar III,Frederick Mosteller |
Publsiher | : CRC Press |
Total Pages | : 490 |
Release | : 2019-05-20 |
Genre | : Mathematics |
ISBN | : 9780429529603 |
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This work explains the purpose of statistical methods in medical studies and analyzes the statistical techniques used by clinical investigators, with special emphasis on studies published in "The New England Journal of Medicine". It clarifies fundamental concepts of statistical design and analysis, and facilitates the understanding of research results.