Diagnostic Hematology

Diagnostic hematology is a problem-solving process involving the gathering and analysis of the relevant findings in each case. Based on the combination of clinical and laboratory data, an experienced diagnostician can formulate the overall 'pattern' of a case. The 'pattern approach' to differential diagnosis is an integral component of the diagnostic reasoning of many expert hematologists. In this unique textbook the authors present a logical and systematic approach to diagnosis, based on the patterns derived from peripheral blood analysis, flow cytometry immunophenotyping studies and bone marrow examination. Unlike standard textbooks which are organized by specific diseases and thereby assume the reader has reached a diagnosis, this text presents the diagnostic problem as it is investigated in practice. The patterns formed by different blood and bone marrow disorders are described in detail and illustrated with color photomicrographs, or flow cytometry graphics. The reader is taken through the process of reaching the differential diagnosis. Advice is given on the proper approach to diagnostic work-up and how to avoid common diagnostic pitfalls. The companion CD-ROM, with full instructions given in the appendix, offers the reader the chance to assess real test results, and see the patterns which lead to the final interpretation in over 200 cases. As a result the reader will develop the skill of pattern recognition and be able to incorporate this diagnostic approach in practice. This is an essential text for physicians practicing hematology and hematopathology, especially those interpreting peripheral blood, flow cytometry and bone marrow specimens; also for technologists and laboratory staff responsible for the screening of full blood counts, the initial review of blood/bone marrow films or immunophenotyping data. System requirements: Windows 95, Windows 98 or Windows NT. Screen resolution of 800 x 600 with 16 million colours (24-bit). Minimum display: at least 65,000 colours (16-bit).

The approach described in this book is different from that in most student texts, and has been very successful in practice, starting almost from scratch, but omitting many of the ‘basics’ such as the details of hematopoiesis, laboratory technology, and so on, which are hardly relevant to the practising clinician and student in the wards, and are primarily of interest to the hematologist and sometimes to the clinical specialist. Considerable emphasis is given to the clinical history and examination, and the interpretation of the clinical patterns thus exposed. Hopefully it will overcome many of the traditional problems experienced in practical diagnostic haematology.

Ideal as a quick, easy-to-use reference in the laboratory or clinical setting, Atlas of Diagnostic Hematology is an abundantly illustrated guide to the vast range of malignant and non-malignant disorders of the blood. More than 1,200 vibrant, full-color images enable you to identify and compare the unique clinical and histologic features of various blood disorders and confidently reach a diagnosis. Coverage includes photos of actual cases that span the entire range of this complex field, including rare conditions and difficult diagnoses. Features more than 1,200 images including full-color pathologic and clinical images covering a wide range of hematologic malignant and non-malignant conditions. Covers a range of disease stages, from the slightest indication where diagnosis can be complicated or missed entirely, to what the average blood or biopsy sample signifying disease may look like, to an advanced stage where disease indications are abundantly clear. Helps you distinguish between similar and overlapping features and symptoms to arrive at an accurate diagnosis. Provides up-to-date information on infectious processes in blood and bone marrow, classification system of myeloid neoplasms, and indolent and aggressive mature T and NK-cell lymphomas. Includes diagnostic algorithms with differential diagnoses for conditions with similar histologic features and clinical symptoms. Contains the latest WHO classifications for pathologic, genetic, and clinical information.

Long-trusted and respected in the field, Diagnostic Cytology and Hematology of the Dog and Cat, 3rd Edition is a complete resource for developing and enriching the knowledge and skills needed for clinical laboratory diagnostics. Detailed illustrations and descriptions of cytologic and hematologic samples enable you to diagnose both common and uncommon diseases in dogs and cats. This concise source of microscopic evaluation techniques and interpretation guidelines for organ tissue, blood, and other body fluid specimens provides you with a basic understanding of sample collection and specimen preparation. Plus, helpful and easier-to-understand algorithms are generously distributed throughout the text, providing clear, easy-to-follow guidelines for diagnosis and treatment. Detailed instructions for in-house laboratory evaluation, as well as submission and transport of samples for commercial laboratory interpretation, are featured in tips and pitfalls throughout discussions on specimen preparation and diagnosis. Easier-to-follow algorithms, additional tables, and a user-friendly format allow quick and easy access to the most relevant information needed in a cytologic diagnosis. Over 1,000 high-quality illustrations help you identify normal versus abnormal cells, enabling you to make accurate diagnoses. Four new chapters—Cell Types and Criteria of Malignancy, Selected Infectious Agents, Round Cell Tumors, and The Pancreas—present detailed information on these topics and how they relate to disease. Highly-respected expert contributors share their expertise from both academia and commercial diagnostic laboratories to provide the best and most current information available. The Lung and Intrathoracic Structures, The Gastrointestinal Tract, and Effusions: Abdominal, Thoracic, and Pericardial chapters have been expanded for more complete and up-to-date coverage of these important topics.

Diagnostic Cytology and Hematology of the Horse is a practical reference that presents common clinical findings in an easy-to-use text/atlas format. A general chapter discusses sample collections and techniques, followed by a 'systems' approach and chapters on specific types of fluid. Within systems chapters, normal findings are established and then abnormal findings are presented by class of problems, such as bacterial lesions, fungal lesions, parasitic lesions, etc. in the case of the eye. Algorithms on sample evaluations enhance text discussions by guiding readers to the most likely cytologic diagnosis. In addition, a color plate section features 64 illustrations for convenient comparison of cell types and infectious agents. A detailed index makes this edition even more useful as a quick clinical reference, ideal for helping readers understand correct collection and handling procedures, avoid costly errors, and make accurate diagnoses.

The purpose of this text is to present a complete hematology course for Clinical Laboratory Science (CLS) students, as well as to provide a resource for clinical laboratory practitioners, medical students, and residents. It presents an in-depth study of cell counting, morphologic differentiation and evaluation, and related areas, such as flow cytometry, immunohistochemistry, and cytogenetics. A chapter on specific age groups covers the unique aspects of hematology in the pediatric and geriatric populations. A section on the etiology and treatment of leukocyte neoplasms has been included to provide some insight into the special considerations of oncologic disorders. Chapters begin with an outline and learning objectives, and color figures are presented as close to the citation as possible to facilitate understanding of the discussion. Most chapters end with a summary, and in many cases, review questions or case studies are included to assess or reinforce understanding of the material.

A vital resource on blood and bone marrow cell morphology in laboratory animal medicine. This fully revised new edition is an essential reference for clinical pathologists in diagnostic laboratories, and medical or veterinary research. The atlas contains over 400 color images of cells from the peripheral blood and bone marrow from a variety of animals encountered in laboratory animal medicine, in health and disease. Key features: New chapter on flow cytometry and its application in terms of routine analyses as a means of identifying abnormalities in cell marker expression, which is of particular relevance for pre-clinical safety assessment Covers the most recent developments in laboratory animal hematology, including parameters measured by the latest generation of analyzers Coverage of a wide range of laboratory animal species, as well as those used in clinical veterinary trials Photomicrographs present normal and abnormal blood cells from a variety of hematological conditions along with descriptive text

Combining essential hematology content with the diagnostic features of an atlas, Veterinary Hematology: A Diagnostic Guide and Color Atlas delivers all the information you need to accurately assess and diagnose the blood diseases of common domestic animals — including dogs, cats, horses, cattle, sheep, goats, pigs, and llamas. This all-in-one resource utilizes a clinically-oriented and user-friendly approach to guide you through the processes of selecting relevant diagnostic tests, collecting and preparing samples, interpreting sample results, and determining their clinical significance. High-resolution photomicrographs, full-color illustrations, and excellent schematic drawings, tables, and quick-reference algorithms help you clearly visualize these concepts and procedures. Two books in one gives you the information of a user-friendly, clinical textbook and the diagnostic features of a color atlas in a single reference. Practical, clinically-relevant text is comprehensive and yet concise in its delivery of vital information such as: Principles and procedures that are employed in recognizing normal, abnormal, and artifactual features of blood and bone marrow samples and developing accurate diagnoses Common cytochemical stains and summary charts for interpretation Sample collection, staining procedures, and diagnostic techniques Differentiating features of malignant and benign hematologic disorders Miscellaneous cells and blood parasites and their significance in the evaluation of blood smears Hematopoietic and non-hematopoietic neoplasms High- resolution photomicrographs and excellent schematic drawings, tables, boxes and quick-reference algorithms aid your understanding of basic clinical concepts and differential diagnostic considerations. Over 800 full-color illustrations help you clearly visualize the concepts and clinical features of the blood and bone marrow — from normal cell maturation to the development of various pathologies.