Discovering The Human Connectome

A pioneer in the field outlines new empirical and computational approaches to mapping the neural connections of the human brain. Crucial to understanding how the brain works is connectivity, and the centerpiece of brain connectivity is the connectome, a comprehensive description of how neurons and brain regions are connected. In this book, Olaf Sporns surveys current efforts to chart these connections—to map the human connectome. He argues that the nascent field of connectomics has already begun to influence the way many neuroscientists collect, analyze, and think about their data. Moreover, the idea of mapping the connections of the human brain in their entirety has captured the imaginations of researchers across several disciplines including human cognition, brain and mental disorders, and complex systems and networks. Discovering the Human Connectome offers the first comprehensive overview of current empirical and computational approaches in this rapidly developing field.

A pioneer in the field outlines new empirical and computational approaches to mapping the neural connections of the human brain. Crucial to understanding how the brain works is connectivity, and the centerpiece of brain connectivity is the connectome, a comprehensive description of how neurons and brain regions are connected. In this book, Olaf Sporns surveys current efforts to chart these connections—to map the human connectome. He argues that the nascent field of connectomics has already begun to influence the way many neuroscientists collect, analyze, and think about their data. Moreover, the idea of mapping the connections of the human brain in their entirety has captured the imaginations of researchers across several disciplines including human cognition, brain and mental disorders, and complex systems and networks. Discovering the Human Connectome offers the first comprehensive overview of current empirical and computational approaches in this rapidly developing field.

“Accessible, witty . . . an important new researcher, philosopher and popularizer of brain science . . . on par with cosmology’s Brian Greene and the late Carl Sagan” (The Plain Dealer). One of the Wall Street Journal’s 10 Best Nonfiction Books of the Year and a Publishers Weekly “Top Ten in Science” Title Every person is unique, but science has struggled to pinpoint where, precisely, that uniqueness resides. Our genome may determine our eye color and even aspects of our character. But our friendships, failures, and passions also shape who we are. The question is: How? Sebastian Seung is at the forefront of a revolution in neuroscience. He believes that our identity lies not in our genes, but in the connections between our brain cells—our particular wiring. Seung and a dedicated group of researchers are leading the effort to map these connections, neuron by neuron, synapse by synapse. It’s a monumental effort, but if they succeed, they will uncover the basis of personality, identity, intelligence, memory, and perhaps disorders such as autism and schizophrenia. Connectome is a mind-bending adventure story offering a daring scientific and technological vision for understanding what makes us who we are, as individuals and as a species. “This is complicated stuff, and it is a testament to Dr. Seung’s remarkable clarity of exposition that the reader is swept along with his enthusiasm, as he moves from the basics of neuroscience out to the farthest regions of the hypothetical, sketching out a spectacularly illustrated giant map of the universe of man.” —TheNew York Times “An elegant primer on what’s known about how the brain is organized and how it grows, wires its neurons, perceives its environment, modifies or repairs itself, and stores information. Seung is a clear, lively writer who chooses vivid examples.” —TheWashington Post

An integrative overview of network approaches to neuroscience explores the origins of brain complexity and the link between brain structure and function. Over the last decade, the study of complex networks has expanded across diverse scientific fields. Increasingly, science is concerned with the structure, behavior, and evolution of complex systems ranging from cells to ecosystems. In Networks of the Brain, Olaf Sporns describes how the integrative nature of brain function can be illuminated from a complex network perspective. Highlighting the many emerging points of contact between neuroscience and network science, the book serves to introduce network theory to neuroscientists and neuroscience to those working on theoretical network models. Sporns emphasizes how networks connect levels of organization in the brain and how they link structure to function, offering an informal and nonmathematical treatment of the subject. Networks of the Brain provides a synthesis of the sciences of complex networks and the brain that will be an essential foundation for future research.

An up-to-date overview of the field of connectomics, introducing concepts and mechanisms underlying brain network change at different stages. The human brain undergoes massive changes during its development, from early childhood and the teenage years to adulthood and old age. Across a wide range of species, from C. elegans and fruit flies to mice, monkeys, and humans, information about brain connectivity (connectomes) at different stages is now becoming available. New approaches in network neuroscience can be used to analyze the topological, spatial, and dynamical organization of such connectomes. In Changing Connectomes, Marcus Kaiser provides an up-to-date overview of the field of connectomics and introduces concepts and mechanisms underlying brain network changes during evolution and development.

Connectome Analysis: Characterization, Methods, and Analysis is a comprehensive companion for the analysis of brain networks, or connectomes. The book provides sources of constituent structural and functional MRI signals, network construction and practices for analysis, cutting-edge methods that address the latest challenges in neuroscience, and the fundamentals of network theory in the context of giving practical methods for building connectomes for analysis. Emphasis is placed on quality control of the individual analysis steps. Subsequent chapters discuss networks in neuroscience in clinical and general populations, including how findings are related to underlying neurophysiology and neuropsychology. This book is aimed at students and early-career researchers in brain connectomics and neuroimaging who have a background in computer science, mathematics and physics, as well as more broadly to neuroscientists and psychologists who want to start incorporating connectomics into their research. Provides practical recommendations on how to construct, assess and analyze brain networks Gives an understanding of all the technical methods for connectome analysis Presents the basic network theoretical principles typically used in neuroscience Covers the latest tools and data repositories that are freely available for the reader to carry out connectomic analyses

In the near future, we will see an increase in the development and use of all sorts of AI applications. Some of the more promising areas will be Finance, Healthcare, IoT, Manufacturing, Journalism, and Cybersecurity. Many of these applications generate a great amount of complex information. Natural Language Understanding is one of the most clear examples. Traditional ways of visualizing complex information, namely linear text, web pages and hyperlink-based applications, have serious productivity problems. Users need a lot of time to visualize the information and have problems seeing the whole picture of the results. Mind mapping is probably the only way of reducing the problems inherent in these traditional ways of visualizing complex information. Most people have no clear idea about the advantages of mind mapping or the problems created by the traditional ways of visualizing complex information. The goal of Mind Mapping and Artificial Intelligence is to provide readers with an introduction to mind mapping and artificial intelligence, to the problems of using traditional ways of visualizing complex information and as an introduction to mind mapping automation and its integration into Artificial Intelligence applications such as NLU and others. As more applications of Artificial Intelligence are developed in the near future, the need for the improvement of the visualization of the information generated will increase exponentially. Information overload will soon also happen in AI applications. This will diminish the advantages of using AI. Author José Maria Guerrero is a long-time expert in mind mapping and visualization techniques. In this book he also introduces readers to MindManager mind mapping software, which can considerably reduce the problems associated with the interpretation of complex information generated by Artificial Intelligence software. Provides coverage of the fundamentals of mind mapping and visualization applied to Artificial Intelligence applications Includes coverage of the scientific bases for mind mapping for the visualization of complex information Introduces MindManager software for mind mapping Introduces the author's MindManager toolkit for the readers to use in development of new mind mapping applications Includes case studies and real-world applications of MindManager for AI applications, including examples using IBM Watson NLU

Psychoanalysis and neurological medicine have promoted contrasting and seemingly irreconcilable notions of the modern self. Since Freud, psychoanalysts have relied on the spoken word in a therapeutic practice that has revolutionized our understanding of the mind. Neurologists and neurosurgeons, meanwhile, have used material apparatus—the scalpel, the electrode—to probe the workings of the nervous system, and in so doing have radically reshaped our understanding of the brain. Both operate in vastly different institutional and cultural contexts. Given these differences, it is remarkable that both fields found resources for their development in the same tradition of late nineteenth-century German medicine: neuropsychiatry. In Localization and Its Discontents, Katja Guenther investigates the significance of this common history, drawing on extensive archival research in seven countries, institutional analysis, and close examination of the practical conditions of scientific and clinical work. Her remarkable accomplishment not only reframes the history of psychoanalysis and the neuro disciplines, but also offers us new ways of thinking about their future.