Drug Induced Headache

M. WILKINSON Patients with frequent or daily headaches pose a very difficult problem for the physician who has to treat them, particularly as many patients think that there should be a medicine or medicines which give them instant relief. In the search for the compound which would meet this very natural desire, many drugs have been manufactured and the temptation for the physician is either to increase the dose of a drug which seems to be, at any rate, partially effective, or to add one or more drugs to those which the patient is already taking. Although there have been some references to the dangers of overdosage of drugs for migraine in the past, it was not until relatively recently that it was recognized that drugs given for the relief of headache, if taken injudiciously, may themselves cause headache. The first drugs to be implicated in this way were ergotamine and phenazone. In the case of ergotamine tartrate, the dangers of ergotism were well known as this was a disorder which had been known and written about for many years. In the treatment of headache, fully blown ergotism is rare and in recent years has usually been due to self-medication in doses much greater than those prescribed although there are a few recorded cases where toxic amounts have been given.

Discussing real-world cases, this practical guide highlights areas of diagnostic uncertainty and shows common pitfalls in headache diagnosis and treatment.

Headache disorders are among the most common disorders of the nervous system. They are pandemic and, in many cases, they are recurrent and can accompany the patient for the whole life. These disorders impose a substantial burden on headache sufferers, on their families and on society: the individual impact is measured by the frequency and severity of attacks, while the societal burden is measured in terms of loss of activity at work and school as well as of costs for the health system. As a matter of facts, headaches are ranked in the top ten, and maybe the top five, causes of disability worldwide: they are therefore extraordinarily common. Population-based studies have mostly focused on migraine, which, even if it is the most frequently studied headache disorder, is not the most common . Other types of headache, such as the more prevalent TTH and sub-types of the more disabling chronic daily headache, have so far received less attention and need to be better investigated. This book will provide a useful tool to a wide medical population, who is required specific skills to diagnose and manage these frequent and often disabling disorders .Furthermore, it could also represents a compendium for medical students who are usually introduced to this topic through multidisciplinary university programmes.

Do you need current and pragmatic guidance in meeting the challenges of acute headache assessment under pressure? Authored by renowned experts in neurology and emergency medicine, this versatile handbook offers practitioners a broad perspective on common, less-common, and rare headache disorders to enable accurate patient diagnosis and effective treatment. Featuring a multidisciplinary team of authors, this textbook provides clinicians who work in acute care settings with the right tools to recognise and understand primary headache disorders and life threatening causes of headache. Covering the best available evidence and practice standards from the emergency department, this guide provides direct answers to challenging management problems. Invaluable and extensively researched, practitioners are able to confidently evaluate a spectrum of conditions, while balancing resource utilization and cost considerations in a time-constrained environment.

There are two crucial issues in the treatment and management of headache patients: More than 50% of individuals experiencing headache have only been treated symptomatically, with no appropriate diagnosis established; and history and neurologic examination are essential to establishing a diagnosis, and thus selecting appropriate therapy. Headache and Migraine Biology and Management is a practical text that addresses these issues, featuring contributions from expert clinical authors. The book covers in detail topics including chronic and episodic migraine, post-traumatic headache, sinus headache, cluster headache, tension headache, and others. Chapters are also dedicated to treatment subjects, including psychiatric and psychological approaches, medication overuse, inpatient treatment, and pediatric issues. This book is an ideal resource for researchers and clinicians, uniting practical discussion of headache biology, current ideas on etiology, future research, and genetic significance and breakthroughs. This resource is useful to those who want to understand headache biology, treat and manage symptoms, and for those performing research in the headache field. A practical discussion of headache biology, current ideas on etiology, future research, and genetic significance and breakthroughs Features chapters from leading physicians and researchers in headache medicine Full-color text that includes both an overview of multiple disciplines and discusses the measures that can be used to treat headaches

This comprehensive, practical title invites all clinicians to take a fresh look at the evaluation and management of chronic daily headache (CDH). Developed by a distinguished international panel of experts, the book examines key social and economic issues around CDH and clarifies the diagnosis of CDH disorders, providing an understanding of the underlying biological substrates, offering guidance on the use of diagnostic testing and additional consultations, and outlining treatment strategies with the greatest potential to alleviate the burden of these patients and to provide the highest quality of care. The book fully examines the constellation of symptoms that constitute chronic daily headache, while also discussing the role of behavioral medicine and the important elements involved in taking a good history. The major forms and biology of chronic daily headache are covered, as is the role of diagnostic testing and treatment. The risk factors that lead patients to transform episodic primary headache disorders into the chronic form are examined. Invasive and neuromodulatory techniques are also discussed. A section on the classification of these disorders rounds out this important contribution to the literature. Chronic Headache – A Comprehensive Guide to Evaluation and Management will be of great interest to neurologists, primary care physicians, nurse practitioners, physician assistants, medical students, and other clinicians with an interest in chronic daily headache.

Now in its third edition, this book remains the only source of comprehensive information about drug-induced neurological disorders. The introduction of new drugs and biological therapies have led to new adverse reactions affecting the nervous system that need to be differentiated from naturally occurring neurological disorders. The book does not simply document adverse reactions but pathomechanisms are described wherever information is available. Methods of management of drug-induced neurological disorders are also described. The primary audience is clinicians involved in the management of neurological and psychiatric disorders. The book is also a useful source of information for neuropharmacologists and pharmaceutical physicians involved in advisory capacities to the biopharmaceutical industry.

Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research. The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. It also contains a section devoted to models of mild CNS injury, including blast and sport-related injuries. Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. This book, with its diverse coherent content, gives you insight into the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.