Drug Metabolism
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Handbook of Drug Metabolism Third Edition
Author | : Paul G. Pearson,Larry C. Wienkers |
Publsiher | : CRC Press |
Total Pages | : 755 |
Release | : 2019-05-20 |
Genre | : Medical |
ISBN | : 9781482262049 |
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This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments. It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecules disposition, stereo-selectivity in drug metabolism, drug transporters and metabolic activation of drugs. Some chapters have been prepared by new authors who have emerged as subject area experts in the decade that has passed since publication of the first edition.
Drug Metabolism in Diseases
Author | : Wen Xie |
Publsiher | : Academic Press |
Total Pages | : 294 |
Release | : 2016-09-12 |
Genre | : Medical |
ISBN | : 9780128029633 |
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Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology. Written and edited by leaders in drug metabolism from academia and industry Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic
Human Drug Metabolism
Author | : Michael D. Coleman |
Publsiher | : John Wiley & Sons |
Total Pages | : 360 |
Release | : 2010-03-30 |
Genre | : Science |
ISBN | : 047068934X |
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Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.
Drug Metabolism
Author | : Jack P. Uetrecht,William Trager |
Publsiher | : CRC Press |
Total Pages | : 200 |
Release | : 2007-06-21 |
Genre | : Medical |
ISBN | : 9781420061086 |
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In order to understand drug metabolism at its most fundamental level, pharmaceutical scientists must be able to analyze drug compound structures and predict possible metabolic pathways in order to avoid the risk of adverse reactions that lead to the withdrawal of a drug from the market. This comprehensive textbook will aid in guiding students throu
Drug Metabolism and Pharmacokinetics Quick Guide
Author | : Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop |
Publsiher | : Springer Science & Business Media |
Total Pages | : 214 |
Release | : 2011-04-07 |
Genre | : Medical |
ISBN | : 9781441956293 |
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Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.
Introduction to Drug Metabolism
Author | : G. Gordon Gibson,Paul Skett |
Publsiher | : Nelson Thornes |
Total Pages | : 274 |
Release | : 2001 |
Genre | : Medical |
ISBN | : 0748760113 |
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Identification and Quantification of Drugs Metabolites Drug Metabolizing Enzymes and Transporters
Author | : Shuguang Ma,Swapan Chowdhury |
Publsiher | : Elsevier Science |
Total Pages | : 708 |
Release | : 2020-07-24 |
Genre | : Science |
ISBN | : 9780128200186 |
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Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade's numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism. Four sections in the book with 24 chapters give readers an overview of state-of-the-art techniques for identifying and quantifying drugs, metabolites and biomarkers, including a chapter on new approaches for quantification of enzymes and transporters in different tissues Focuses on the role of drug metabolism enzymes, transporters in disposition and drug-drug interactions, as well as strategies for evaluating drug metabolism and safety using advanced liver and kidney models. Discussions on immunogenicity risks of biologics and their evaluation methods have been included Includes several chapters on advanced translational sciences to predict human dosage, pharmacokinetics and efficacy for small molecules and biotherapeutics All chapters are written by experts with a wide range of practical experience from the industry and academia
Drug Metabolism
Author | : Mino R. Caira,Corina Ionescu |
Publsiher | : Springer Science & Business Media |
Total Pages | : 422 |
Release | : 2006-07-10 |
Genre | : Medical |
ISBN | : 9781402041426 |
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Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.