Tamoxifen Tales

Tamoxifen Tales: Suggestions for Scientific Survival presents a case study describing the academic journey of teams behind major advances in medical sciences, highlighting lessons learned that are applicable to the next generation of scientists. This book provides a manual on the successful mentoring of young scientists, including stories describing how training experience shaped careers to become leaders in academia and the pharmaceutical industry. The book documents Professor V. Craig Jordan’s 50-year career in medical sciences that led to the discovery and development of Selective Estrogen Receptor Modulators (SERMs), which became the standard of women’s healthcare around the world. Additionally, it illustrates the versatility of a scientist with a commitment to serving societies. This important resource will be a useful and interesting book for established medical scientists, research mentors and advanced students wanting to chart a successful and impactful research career. Highlights lessons learned from the journey behind discovery science that are applicable to the scientific journey of the next generation of scientists Provides a manual on the successful mentoring of young scientists to become leaders in academia and the pharmaceutical industry Examines cancer treatment based on a personal determination to challenge at the frontiers of the science and to relate to personal life experience Includes references for further research reading

The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on hormones and breast cancer. Contributions from leading authorities Informs and updates on all the latest developments in the field

Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental , and clinical data specifically focused on AI resistance in breast cancer. The volume will include three sections. The first section covers general knowledge about aromatase inhibitors, including regulation of aromatase genes, and structure and function of aromatase protein. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance. Breast cancer is the most common female cancer and AIs significantly improve treatments outcomes compatibly to previously used endocrine treatments. However 10-15% of post-operative patients develop a relapse during adjuvant treatment with AIs; about 25-50% of the patients do not respond to AIs in neo-adjuvant or metastatic setting, and the majority of metastatic patients who initially respond develop resistance within 3 years. There is an important need to understand these mechanisms of resistance in order to develop methods of preventing or overcoming the resistance to AIs, which will ensure a more successful outcome in treating breast cancer.

The 5th edition of Glossary of Biotechnology and Agrobiotechnology Terms will be a significant expansion of the previous 4th edition. In the past decade, many new terms have been introduced due to the appearance and application of new crop plant breeding methods as well as technical advances in genetics, molecular biology, cell biology and agricultural research. The terms associated with important new technologies have been added to this new edition including terms related to Zinc Finger Proteins, Transcription Activator-Like Effectors (TALEs), TALE Nucleases, Genome Editing, CRISPR/Cas 9 Gene-editing Systems, Oligonucleortide-mediated Mutagenesis, and RNA Interference, as well as hundreds of others. The 5th edition, like previous editions, will be useful for regulators of agricultural biotechnology around the world, customers, biotech patent officials, venture capitalists, and agbiotech company executives, as well as biopharmaceutical industries and academics.

Nursing Pharmacology Made Incredibly Easy, 3rd Edition, provides the nursing student and practicing nurse with information about how drugs act and interact in the treatment of disease. The book focuses on mechanisms of drug action; details specific drugs by pharmacologic class; reviews the nursing process related to each drug category for all body systems, plus pain medications, anti-infective drugs, and cancer drugs; and highlights potentially dangerous interactions, including drug-herb interactions. It does all of this in the award-winning, lighthearted Incredibly Easy! style that makes intimidating concepts thoroughly approachable.

Nursing Pharmacology Made Incredibly Easy, 3rd Edition, provides the nursing student and practicing nurse with important information about how drugs act and interact in the treatment of disease. This essential pharmacology reference focuses on the mechanisms of drug action; details specific drugs by pharmacologic class; reviews the nursing process related to each drug category for all body systems, plus pain medications, anti-infective drugs, and cancer drugs; and highlights potentially dangerous interactions, including drug-herb interactions. It does all of this in the award-winning, lighthearted Incredibly Easy! style that makes intimidating concepts thoroughly approachable. This completely updated third edition includes the most current NANDA diagnoses and covers Pharmacokinetics, pharmacodynamics, pharmacotherapeutics, interactions, adverse reactions, and nursing process considerations for each drug. If you are still learning, Nursing Pharmacology Made Incredibly Easy will help you master complex subjects in minutes with Quick Quizzes at the end of each chapter to gauge learning and special elements found throughout the text to make it easy to understand and remember key points and information, including: And if that's not enough you can go online to the easiest website to use . . . ever . . . where you'll find valuable resources, including a dosage calculator, pharmacology animations, prototype drug information, medication safety tips, mechanisms of action . . . and Instructor ancillaries, including teaching tips, student activities, test bank, and PowerPoint slides. Your grasp of pharmacology will never be clearer and no text will ever be easier to use than Nursing Pharmacology Made Incredibly Easy!

Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth. Provides a thorough, accessible resource that helps researchers and students employ cellular and animal models in their own genetic and genomic studies Offers guidance on how to effectively interpret the results and significance of genetic and genomic model studies for human health Features chapters from international experts in the use of specific cellular and animal models, including yeast, worms, flies, fish, mice, and large animals, among other organisms