Drugs From Nature Targets Assay Systems And Leads
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Drugs from Nature Targets Assay Systems and Leads
Author | : Madhathilkovilakathu Haridas |
Publsiher | : Springer Nature |
Total Pages | : 572 |
Release | : 2024 |
Genre | : Electronic Book |
ISBN | : 9789819991839 |
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Drugs from Nature Targets Assay Systems and Leads
Author | : Madhathilkovilakathu Haridas,Sabu Abdulhameed,Dileep Francis,Swaroop S Kumar |
Publsiher | : Springer |
Total Pages | : 0 |
Release | : 2024-03-07 |
Genre | : Medical |
ISBN | : 981999182X |
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This book provides an overview of the drug discovery process from natural sources such as plants and microbes. While technological advances have streamlined the drug discovery process, enhancing the throughput and success rates, the structural features of natural products remain the primary reference for small-molecule drug discovery. Focusing on the drug targets blocked/altered by natural/nature-inspired molecules, it covers how potential drug leads are screened and identified using appropriate assay systems, and the current status of drugs identified using such approaches. State-of-the-art approaches in target identification, assay development, and lead identification have also been discussed in detail. Other topics included are targets and leads in inflammation, cancer, reproductive medicine, cardiovascular and neuromuscular ailments, and infectious diseases as well as the challenges in translating drug leads into clinically viable drugs. This volume serves as a handbook for researchers in phytochemistry and drug discovery, and as a reference for researchers and students of applied biology.
Artificial Intelligence in Drug Discovery
Author | : Nathan Brown |
Publsiher | : Royal Society of Chemistry |
Total Pages | : 425 |
Release | : 2020-11-04 |
Genre | : Computers |
ISBN | : 9781839160547 |
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Following significant advances in deep learning and related areas interest in artificial intelligence (AI) has rapidly grown. In particular, the application of AI in drug discovery provides an opportunity to tackle challenges that previously have been difficult to solve, such as predicting properties, designing molecules and optimising synthetic routes. Artificial Intelligence in Drug Discovery aims to introduce the reader to AI and machine learning tools and techniques, and to outline specific challenges including designing new molecular structures, synthesis planning and simulation. Providing a wealth of information from leading experts in the field this book is ideal for students, postgraduates and established researchers in both industry and academia.
The Role of Natural Products in Drug Discovery
Author | : J. Mulzer,R. Bohlmann |
Publsiher | : Springer Science & Business Media |
Total Pages | : 363 |
Release | : 2013-04-17 |
Genre | : Medical |
ISBN | : 9783662040423 |
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Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.
Official Gazette of the United States Patent and Trademark Office
Author | : Anonim |
Publsiher | : Unknown |
Total Pages | : 380 |
Release | : 1993 |
Genre | : Trademarks |
ISBN | : PSU:000066191131 |
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Quality Control and Evaluation of Herbal Drugs
Author | : Pulok K. Mukherjee |
Publsiher | : Elsevier |
Total Pages | : 784 |
Release | : 2019-05-30 |
Genre | : Science |
ISBN | : 9780128133989 |
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Quality Control and Evaluation of Herbal Drugs brings together current thinking and practices for evaluation of natural products and traditional medicines. The use of herbal medicine in therapeutics is on the rise in both developed and developing countries and this book facilitates the necessary development of quality standards for these medicines.This book elucidates on various challenges and opportunities for quality evaluation of herbal drugs with several integrated approaches including metabolomics, chemoprofiling, marker analysis, stability testing, good practices for manufacturing, clinical aspects, Ethnopharmacology and Ethnomedicine inspired drug development. Written by Prof. Pulok K Mukherjee, a leader in this field; the book highlights on various methods, techniques and approaches for evaluating the purity, quality, safety and efficacy of herbal drugs. Particular attention is paid to methods that assess these drugs’ activity, the compounds responsible and their underlying mechanisms of action. The book describes the quality control parameters followed in India and other countries, including Japan, China, Bangladesh, and other Asian countries, as well as the regulatory profiles of the European Union and North America. This book will be useful in bio-prospecting of natural products and traditional medicine-inspired drug discovery and development. Provides new information on the research and development of natural remedies - essential reading on the study and use of natural resources for preventative or healing purposes Brings together current thinking and practices in quality control and standardization of herbal drugs highlighting several integrated approaches for metabolomics, chemo-profiling and marker analysis Aids in developing knowledge of various techniques including macroscopy, microscopy, HPTLC, HPLC, LC-MS/MS, GC-MS etc. with the development of integrated methods for evaluation of botanicals used in traditional medicine Assessment of herbal drugs through bio-analytical techniques, bioassay guided isolation, enzyme inhibition, pharmacological, microbiological, antiviral assays and safety related quality issues References global organizations, such as the WHO, USFDA, CDSCO, AYUSH, TCM and others to serve as a comprehensive document for enforcement agencies, NGOs and regulatory authorities
Drug Targeting and Stimuli Sensitive Drug Delivery Systems
Author | : Alexandru Mihai Grumezescu |
Publsiher | : William Andrew |
Total Pages | : 836 |
Release | : 2018-05-21 |
Genre | : Science |
ISBN | : 9780128136904 |
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Drug Targeting and Stimuli Sensitive Drug Delivery Systems covers recent advances in the area of stimuli sensitive drug delivery systems, providing an up-to-date overview of the physical, chemical, biological and multistimuli-responsive nanosystems. In addition, the book presents an analysis of clinical status for different types of nanoplatforms. Written by an internationally diverse group of researchers, it is an important reference resource for both biomaterials scientists and those working in the pharmaceutical industry who are looking to help create more effective drug delivery systems. Shows how the use of nanomaterials can help target a drug to specific tissues and cells Explores the development of stimuli-responsive drug delivery systems Includes case studies to showcase how stimuli responsive nanosystems are used in a variety of therapies, including camptothecin delivery, diabetes and cancer therapy
The Science and Business of Drug Discovery
Author | : Edward D. Zanders |
Publsiher | : Springer Science & Business Media |
Total Pages | : 397 |
Release | : 2011-07-08 |
Genre | : Medical |
ISBN | : 9781441999023 |
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The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key information. Each of the nineteen chapters is illustrated with figures and tables which clarify some of the more technical points being made. Also included is a drug discovery case history which draws the relevant material together into a single chapter. In recognizing that it is difficult to navigate through the many external resources dealing with drug development, the book has been written to guide the reader towards the most appropriate information sources, including those listed in the two appendices. The following topics are covered: Different types of drugs: from small molecules to stem cells Background to chemistry of small and large molecules Historical background to drug discovery, pharmacology and biotechnology The drug discovery pipeline: from target discovery to marketed medicine Commercial aspects of drug discovery Challenges to the biopharmaceutical industry and its responses Material of specific interest to technology transfer executives, recruiters and pharmaceutical translators.