Dysbiosis In Human Disease

Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease. The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states. Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity – periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section. The discussion moves on to the major ‘idiopathic’ diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position. Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition Explores the relationship humans have with their microbiota, and its significance in human health and disease Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases.

FULL-COLOR PRINTING: This clinical monograph is now included in Chapter 4.2 of "Inflammation Mastery 4th Edition" (ISBN 0990620484) and "Textbook of Clinical Nutrition and Functional Medicine, Vol. 1" (ISBN 099062045X). About this book and series: This book-first in the series on microbiome and dysbiosis-contains the study notes, text, diagrams, explanations, and sample examination questions for the online continuing education course series "Human Microbiome and Dysbiosis in Clinical Disease" described at ICHNFM.ORG/cme. Reading of this book is necessary for successful completion of the continuing education activities; video access to this updated material along with exam access and certificate of continuing education must be purchased/accessed separately while access via hyperlinks and passwords to other previous/ancillary videos is provided in this book. About the series: This is an updated excerpt-focusing on dysbiosis-from Functional Inflammology-Volume 1: Introduction to Clinical Nutrition, Functional Medicine, and Integrative Pain Management, the culmination of data from several thousand research publications combined with Dr Vasquez's many years of clinical experience and teaching graduate-level students and doctorate-level clinicians worldwide. Using illustrations, flowcharts, acronyms, and detailed-yet-simplifying explanations, Dr Vasquez makes the learning process easier than ever for clinicians to grasp important concepts in integrative care and functional medicine and then to translate the basic science research, molecular biology, and clinical data into treatment plans that can be explained and used in "the real world" of clinical practice with patients. The associated video tutorials and recorded live conference presentations further help students and clinicians "get it" via Dr Vasquez's effective teaching style which embraces complexity while always emphasizing clinical applicability and psychosocial context. The Inflammation Mastery & Functional Inflammology series of books and videos translates important concepts and nutritional/biomedical science into easy and practical clinical applications for the prevention and treatment of disorders of sustained inflammation, which Dr Vasquez describes as "patterns of metabolic disturbance and inflammatory dysfunction" existing in three sequential and overlapping categories: 1) metabolic inflammation, 2) allergic inflammation, and 3) autoimmune inflammation. For more insights and clinical applications, please see the full version of Functional Inflammology: Volume 1.

In the last decades, the importance of gut microbiome has been linked to medical research on different diseases. Developments of other medical disciplines (human clinical pharmacology, clinical nutrition and dietetics, everyday medical treatments of antibiotics, changes in nutritional inhabits in different countries) also called attention to study the changes in the gut microbiome. This book contains five excellent review chapters in the field of gut microbiome, written by researchers from the USA, Canada, China, and India. These chapters present a critical review about some clinically important changes in the gut microbiome in the development of some human diseases and therapeutic possibilities (liver disease, cardiovascular diseases, brain diseases, gastrointestinal diseases). The book brings to attention the essential role of gut microbiome in keeping our life healthy. This book is addressed to experts of microbiology, podiatrists, gastroenterologists, internists, nutritional experts, cardiologists, basic and clinical researchers, as well as experts in the field of food industry.

Dr. Fasano holds stocks in Alba Therapeutics and receives financial support from Takeda Pharmaceuticals. Dr. Taneja receives financial support from Elysium Health and Evelo Biosciences. The other Topic Editors declare no competing interests with regards to the Research Topic subject.

The Microbiota in Gastrointestinal Pathophysiology: Implications for Human Health, Prebiotics, Probiotics and Dysbiosis is a one-stop reference on the state-of-the-art research on gut microbial ecology in relation to human disease. This important resource starts with an overview of the normal microbiota of the gastrointestinal tract, including the esophagus, stomach, Ileum, and colon. The book then identifies what a healthy vs. unhealthy microbial community looks like, including methods of identification. Also included is insight into which features and contributions the microbiota make that are essential and useful to host physiology, as is information on how to promote appropriate mutualisms and prevent undesirable dysbioses. Through the power of synthesizing what is known by experienced researchers in the field, current gaps are closed, raising understanding of the role of the microbiome and allowing for further research. Explains how to modify the gut microbiota and how the current strategies used to do this produce their effects Explores the gut microbiota as a therapeutic target Provides the synthesis of existing data from both mainstream and non-mainstream sources through experienced researchers in the field Serves as a ‘one-stop’ shop for a topic that’s currently spread across a number of various journals

DISCOUNTED BLACK AND WHITE PRINTING: This clinical monograph is now included in Chapter 4.2 of "Inflammation Mastery 4th Edition" (ISBN 0990620484) and "Textbook of Clinical Nutrition and Functional Medicine, Vol. 1" (ISBN 099062045X). About this book and series: This book-first in the series on microbiome and dysbiosis-contains the study notes, text, diagrams, explanations, and sample examination questions for the online continuing education course series "Human Microbiome and Dysbiosis in Clinical Disease" described at ICHNFM.ORG/cme. Reading of this book is necessary for successful completion of the continuing education activities; video access to this updated material along with exam access and certificate of continuing education must be purchased/accessed separately while access via hyperlinks and passwords to other previous/ancillary videos is provided in this book. About the series: This is an updated excerpt-focusing on dysbiosis-from Functional Inflammology-Volume 1: Introduction to Clinical Nutrition, Functional Medicine, and Integrative Pain Management, the culmination of data from several thousand research publications combined with Dr Vasquez's many years of clinical experience and teaching graduate-level students and doctorate-level clinicians worldwide. Using illustrations, flowcharts, acronyms, and detailed-yet-simplifying explanations, Dr Vasquez makes the learning process easier than ever for clinicians to grasp important concepts in integrative care and functional medicine and then to translate the basic science research, molecular biology, and clinical data into treatment plans that can be explained and used in "the real world" of clinical practice with patients. The associated video tutorials and recorded live conference presentations further help students and clinicians "get it" via Dr Vasquez's effective teaching style which embraces complexity while always emphasizing clinical applicability and psychosocial context. The Inflammation Mastery & Functional Inflammology series of books and videos translates important concepts and nutritional/biomedical science into easy and practical clinical applications for the prevention and treatment of disorders of sustained inflammation, which Dr Vasquez describes as "patterns of metabolic disturbance and inflammatory dysfunction" existing in three sequential and overlapping categories: 1) metabolic inflammation, 2) allergic inflammation, and 3) autoimmune inflammation. For more insights and clinical applications, please see the full version of Functional Inflammology: Volume 1.

This book will be updated/replaced in March 2015 by its Second Edition, which will be the study guide for the online CME course taught by Dr Vasquez. This book is a 3-part Learning System of Text, Slides, and Video: -- excerpted from Functional Inflammology Volume 1 (ISBN 0990620409) -- providing 92 pages of text, 138 presentation slides -- printed with Colorized Text and Diagrams -- providing more than 14 Hours of Video Access This is an excerpt -- focusing on dysbiosis, providing 92 pages of text, 138 presentation slides, and more than 11 hours of video -- from Functional Inflammology: Introduction to Clinical Nutrition, Functional Medicine, and Integrative Pain Management, the culmination of several thousand research publications combined with Dr Vasquez's many years of clinical experience and teaching graduate-level students and doctorate-level clinicians worldwide. With the photos, diagrams, acronyms, illustrations and explanations, Dr Vasquez makes it easier than ever for clinicians to grasp important concepts and then apply the basic science research and molecular biology in to treatment plans that can be explained and applied in "the real world" of clinical practice with patients. The associated video tutorials and recorded live conference presentations further help students and clinicians "get it" via Dr Vasquez's teaching style which embraces complexity while always emphasizing clinical applicability and psychosocial context. The Inflammation Mastery & Functional Inflammology series of books and videos translates important concepts and nutritional/biomedical science into easy and practical clinical applications for the prevention and treatment of disorders of sustained inflammation, which Dr Vasquez describes as "patterns of metabolic disturbance and inflammatory dysfunction" existing in three sequential and overlapping categories: 1) metabolic inflammation, 2) allergic inflammation, 3) autoimmune inflammation. This book includes access to video presentations which introduce the origin and components of the Functional Inflammology Protocol and FINDSEX(r) acronym. Post-publication updates to this information and important social and clinical contextualization are contained in the accompanying videos-hyperlinks and passwords are provided via newsletters and as described within this book.

The Gut Microbiota in Health and Disease An accessible overview of the varied microorganisms of the gut The human gut contains an extraordinary array of microorganisms existing in intricate symbiosis with the body. The gut microbiota plays a crucial role in maintaining overall gut health and warding off disease. With up to 15% of the global population suffering from Irritable Bowel Syndrome (IBS) caused by improper composition of gut microbiota, understanding these organisms and their vital contribution to human health has never been more important. The Gut Microbiota in Health and Disease provides a concise, accessible introduction to gut microbiota and their contribution to human health. It offers not only an overview of the relevant microorganisms and their roles in the body, but also extended discussion of diseases caused by gut dysbiosis. It presents a crucial window into this growing body of research into a critical area of overall human health. The Gut Microbiota in Health and Disease, readers will also find: Detailed analysis of dysbiotic health conditions including obesity, diabetes, and more Thorough treatment of molecular techniques for the analysis gut microbial composition Discussion of the lowering diversity of bacteria in the gut and the corresponding impact on global health The Gut Microbiota in Health and Disease is essential for researchers and clinicians working in immunology, gastroenterology, clinical microbiology, and related fields, as well as for clinical dieticians and postgraduate or medical students studying in these areas.