Ebola Virus Disease

Ebola Virus Disease: From Origins to Outbreak covers Ebola virus disease in its entirety from its origins through major outbreaks in the past to the present day outbreak. It contains information on the West Saharan response to Ebola as well as highlights from the field in West Africa from Dr. Qureshi and Dr. Chughtai, helping to solve the primary question of what’s next and aiding in formulating a path forward. With a growing awareness of the devastating effects of this viral disease and an influx of topical research, this book provides the information the global community of researchers, clinicians and students need to better inform their research and study of Ebola virus disease. Includes perspectives from the 2014-2015 outbreak from the field Provides a detailed overview of the origins of Ebola virus through present day discoveries Written with an integrative approach, incorporating scientific research with insights from the field

The most recent Ebola epidemic that began in late 2013 alerted the entire world to the gaps in infectious disease emergency preparedness and response. The regional outbreak that progressed to a significant public health emergency of international concern (PHEIC) in a matter of months killed 11,310 and infected more than 28,616. While this outbreak bears some unique distinctions to past outbreaks, many characteristics remain the same and contributed to tragic loss of human life and unnecessary expenditure of capital: insufficient knowledge of the disease, its reservoirs, and its transmission; delayed prevention efforts and treatment; poor control of the disease in hospital settings; and inadequate community and international responses. Recognizing the opportunity to learn from the countless lessons of this epidemic, the National Academies of Sciences, Engineering, and Medicine convened a workshop in March 2015 to discuss the challenges to successful outbreak responses at the scientific, clinical, and global health levels. Workshop participants explored the epidemic from multiple perspectives, identified important questions about Ebola that remained unanswered, and sought to apply this understanding to the broad challenges posed by Ebola and other emerging pathogens, to prevent the international community from being taken by surprise once again in the face of these threats. This publication summarizes the presentations and discussions from the workshop.

The Ebola and Marburg viruses are a pair of filoviruses that are among the most lethal hemorrhagic viruses on the planet. The authors present a review of past and current research into these pathogens, including 12 papers addressing the structure of the viral proteins; genomic replication; molecular mechanisms of entry; pathogenesis in nonhuman primates, guinea pigs, and mice; virus modulation of innate immunity; and cellular and molecular mechanisms of Ebola pathogenicity and related approaches to vaccine development.

Tropical emerging diseases pose a significant risk for the circulation of old and new pathogens in areas previously unknown, also implying the possibility of new morbidities and mortalities and new consequences for naïve populations. Globalization, migration and travel are key factors for tropical diseases, and represent the need for integration of tropical medicine, travel medicine and epidemiology in the understanding of such complex situations. Neglected tropical diseases such as leprosy or Chagas disease, arboviral diseases, HIV, Ebola, and arenaviral infections are just a few examples. This book tries to update significant epidemiological and clinical research in many aspects with a multinational perspective.

These books on diseases will be useful in the library for reports or in the classroom for science and health education courses. The authors discuss diagnosis, treatment, and prevention of each disease and look at possibilities for the future, including new research toward faster and better cures. Each book contains fascinating case studies, as well as questions and answers, a timeline, further information, chapter notes, a glossary, a further reading list, Internet resources, and an index.

As the culminating volume in the DCP3 series, volume 9 will provide an overview of DCP3 findings and methods, a summary of messages and substantive lessons to be taken from DCP3, and a further discussion of cross-cutting and synthesizing topics across the first eight volumes. The introductory chapters (1-3) in this volume take as their starting point the elements of the Essential Packages presented in the overview chapters of each volume. First, the chapter on intersectoral policy priorities for health includes fiscal and intersectoral policies and assembles a subset of the population policies and applies strict criteria for a low-income setting in order to propose a "highest-priority" essential package. Second, the chapter on packages of care and delivery platforms for universal health coverage (UHC) includes health sector interventions, primarily clinical and public health services, and uses the same approach to propose a highest priority package of interventions and policies that meet similar criteria, provides cost estimates, and describes a pathway to UHC.

Imagine a killer with the infectiousness of the common cold and power of the Black Death. Imagine something so deadly that it wipes out 90% of those it touches. Imagine an organism against which there is no defence. But you don't need to imagine. Such a killer exists: it is a virus and its name is Ebola. The Hot Zone tells what happens when the unthinkable becomes reality: when a deadly virus, from the rain forests of Africa, crosses continents and infects a monkey house ten miles from the White House. Ebola is that reality. It has the power to decimate the world's population. Try not to panic. It will be back. There is nothing you can do...

Divided into three sections along the lines of bacteriology, parasitology and virology, this book comprehensively provides a systematic, cross disciplinary approach to the science and control of all zoonoses, written by international specialists in human and veterinary medicine.