Electronic Noses For Biomedical Applications And Environmental Monitoring

This book, titled “Electronic Noses for Biomedical Applications and Environmental Monitoring”, includes original research works and reviews concerning the use of electronic nose technology in two of the more useful and interesting fields related to chemical compounds detection of gases. Authors have explained their latest research work, including different gas sensors and materials based on nanotechnology and novel applications of electronic noses for the detection of diverse diseases. Some reviews related to disease detection through breath analysis, odor monitoring systems standardization, and seawater quality monitoring are also included.

This book, titled “Electronic Noses for Biomedical Applications and Environmental Monitoring”, includes original research works and reviews concerning the use of electronic nose technology in two of the more useful and interesting fields related to chemical compounds detection of gases. Authors have explained their latest research work, including different gas sensors and materials based on nanotechnology and novel applications of electronic noses for the detection of diverse diseases. Some reviews related to disease detection through breath analysis, odor monitoring systems standardization, and seawater quality monitoring are also included.

At a time when the applications of sensors are in high demand and environmental issues are international priorities, this book on biomedical and environmental sensing provides the technical basis for researchers and students to understand the requirements for biomedical computing and also environmental sensing and to develop solutions in their areas of interests. The book deals with key techniques that need to be understood and also examples of applications of the techniques. Biomedical and environmental sensing are helping to extend the life span of human beings and infrastructures as it has become more and more sensible to understand what is happening for example inside a person, an aircraft, a road network or a bridge and to provide quick response.Several chapters of the book have dealt with the state of the art in biomedical decision support systems in therapeutic medicine. A data driven decision support system and a prototype support system for anaesthetics are major enablers for doctors and nurses to provide efficient and timely response not only to diagnose ailments but also to decide on the preferred approach for solving the problems. The analyses in the chapters are coherently detailed and easy to comprehend. There is a chapter on hypothermia therapy and a hardware probe was also developed and described. Classification of chromosomes is a major aid in DNA analysis and recognition. This valuable insight into a DNA analysis method is provided. Information on heart diseases, onset of heart attacks and failure can be detected through reconstructing electrophysiological information about the surface of the heart. A reconstruction method is described in this book and provides strong foundation for research and training in this life determining area. The remaining chapters on sensing of driver conditions including fatigue peeks into tools and methodologies for understanding both the onset of fatigue and its forms for prevention of accidents in vehicles. The rest of the book gives techniques for planning biomedical and environmental sensor networks and their security. The book will no doubt greatly serve the needs of health professionals, researchers in the health and environmental industry and policy makers.

The field of plasmonics has shown extraordinary capabilities in realizing highly sensitive and accurate sensors for environmental monitoring and measurement of biological analytes. The inherent potential of such devices has led to growing interest worldwide in commercial fiber optic chemical and biosensors. Optical Sensors for Biomedical Diagnostics and Environmental Monitoring is an essential resource for students, established researchers, and industry developers in need of a reference work on both the fundamentals and latest advances in optical fiber sensor technology in biomedical diagnostics and environmental monitoring. The book includes rigorous theory and experimental techniques of surface plasmon and lossy mode resonances, as well as real-time sensing applications of resonance techniques implemented over optical fiber substrate using bulk layer and/or nanostructures as transducer and sensing layers. In addition, discussion of various design options for real-time sensors in environmental monitoring and biomedical diagnostics make the book approachable to readers from multidisciplinary fields.

Sensors and Sensory Systems for an Electronic Nose reviews the current state of progress in the development of an electronic instrument capable of olfaction. The instrument -- the so-called electronic nose -- has enormous potential for application in such areas as product flavor control and environmental monitoring. The book discusses the essential elements of an electronic nose, such as chemical sensors, signal processing, and pattern recoginiton techniques. It is also one of the first contributions to the new and exciting field of machine olfaction.

In developing the electronic nose and biosensor devices, researchers not only copy biochemical pathways, but also use nature's approach to signal interpretation as a blueprint for man-made sensing systems. Commercial biosensors have demonstrated their benefits and practical applications, providing high sensitivity and selectivity, combined with a significant reduction in sample preparation assay time and the use of expensive reagents. The Handbook of Biosensors and Electronic Noses discusses design and optimization for the multitude of practical uses of these devices including:

Provides an introduction to the topic of smart chemical sensors, along with an overview of the state of the art based on potential applications This book presents a comprehensive overview of chemical sensors, ranging from the choice of material to sensor validation, modeling, simulation, and manufacturing. It discusses the process of data collection by intelligent techniques such as deep learning, multivariate analysis, and others. It also incorporates different types of smart chemical sensors and discusses each under a common set of sub-sections so that readers can fully understand the advantages and disadvantages of the relevant transducers—depending on the design, transduction mode, and final applications. Smart Sensors for Environmental and Medical Applications covers all major aspects of the field of smart chemical sensors, including working principle and related theory, sensor materials, classification of respective transducer type, relevant fabrication processes, methods for data analysis, and suitable applications. Chapters address field effect transistors technologies for biological and chemical sensors, mammalian cell–based electrochemical sensors for label-free monitoring of analytes, electronic tongues, chemical sensors based on metal oxides, metal oxide (MOX) gas sensor electronic interfaces, and more. Addressing the limitations and challenges in obtaining state-of-the-art smart biochemical sensors, this book: Balances the fundamentals of sensor design, fabrication, characterization, and analysis with advanced methods Categorizes sensors into sub-types and describes their working, focusing on prominent applications Describes instrumentation and IoT networking methods of chemical transducers that can be used for inexpensive, accurate detection in commercialized smart chemical sensors Covers monitoring of food spoilage using polydiacetylene- and liposome-based sensors; smart and intelligent E-nose for sensitive and selective chemical sensing applications; odor sensing system; and microwave chemical sensors Smart Sensors for Environmental and Medical Applications is an important book for senior-level undergraduate and graduate students learning about this high-performance technology and its many applications. It will also inform practitioners and researchers involved in the creation and use of smart sensors.

Sensor Technologies: Healthcare, Wellness and Environmental Applications explores the key aspects of sensor technologies, covering wired, wireless, and discrete sensors for the specific application domains of healthcare, wellness and environmental sensing. It discusses the social, regulatory, and design considerations specific to these domains. The book provides an application-based approach using real-world examples to illustrate the application of sensor technologies in a practical and experiential manner. The book guides the reader from the formulation of the research question, through the design and validation process, to the deployment and management phase of sensor applications. The processes and examples used in the book are primarily based on research carried out by Intel or joint academic research programs. “Sensor Technologies: Healthcare, Wellness and Environmental Applications provides an extensive overview of sensing technologies and their applications in healthcare, wellness, and environmental monitoring. From sensor hardware to system applications and case studies, this book gives readers an in-depth understanding of the technologies and how they can be applied. I would highly recommend it to students or researchers who are interested in wireless sensing technologies and the associated applications.” Dr. Benny Lo Lecturer, The Hamlyn Centre, Imperial College of London “This timely addition to the literature on sensors covers the broad complexity of sensing, sensor types, and the vast range of existing and emerging applications in a very clearly written and accessible manner. It is particularly good at capturing the exciting possibilities that will occur as sensor networks merge with cloud-based ‘big data’ analytics to provide a host of new applications that will impact directly on the individual in ways we cannot fully predict at present. It really brings this home through the use of carefully chosen case studies that bring the overwhelming concept of 'big data' down to the personal level of individual life and health.” Dermot Diamond Director, National Centre for Sensor Research, Principal Investigator, CLARITY Centre for Sensor Web Technologies, Dublin City University "Sensor Technologies: Healthcare, Wellness and Environmental Applications takes the reader on an end-to-end journey of sensor technologies, covering the fundamentals from an engineering perspective, introducing how the data gleaned can be both processed and visualized, in addition to offering exemplar case studies in a number of application domains. It is a must-read for those studying any undergraduate course that involves sensor technologies. It also provides a thorough foundation for those involved in the research and development of applied sensor systems. I highly recommend it to any engineer who wishes to broaden their knowledge in this area!" Chris Nugent Professor of Biomedical Engineering, University of Ulster What you’ll learnThe relevant sensing approaches and the hardware and software components required to capture and interpret sensor data. The importance of regulations governing medical devices. A design methodology for developing and deploying successful home- and community-based technologies, supported by relevant case studies. Health, wellness, and environmental sensing applications and how they work. The challenges and future directions of sensing in these domains. Who this book is for Sensor Technologies: Healthcare, Wellness and Environmental Applications is targeted at clinical and technical researchers, engineers, and students who want to understand the current state of the art in sensor applications in these domains. The reader gains a full awareness of the key technical and non-technical challenges that must be addressed in the development of successful end-to-end sensor applications. Real-world examples help give the reader practical insights into the successful development, deployment, and management of sensor applications. The reader will also develop an understanding of the personal, social, and ethical impact of sensor applications, now and in the future. Table of ContentsChapter One: Introduction Chapter Goal: Reader should understand the key challenges and drivers for sensor application development. The reader should also understand how sensor technologies can play a role in addressing some of the key challenges facing global society in the short to medium term. 1. Book overview 2. Drivers for Sensor Applications (Infrastructure Growth in Developing Countries, Advances in Energy Harvesting, New Applications, Cost reduction, Real-time monitoring of situations to avoid unplanned downtime, Security (personal and national), the internet of things). 3. Challenges for Sensor Applications (Power, Efficient Operation in Harsh Environments, Number of Deployable Nodes, Safety and Regulations, High Cost of Installation, Security and Reliability, sensor management) 4. Global Megatrends and the opportunities for sensing technologies o Water and Food Constraints o Aging Demographics o Public Health o Pandemics o Security Chapter 2: Sensing and Sensor Fundamentals Chapter Goal: Reader should understand existing sensor technologies, which can be used in healthcare, wellness, and environmental domains. They should also understand the role of smart sensors and smart phones as mobile sensing platforms and aggregators. 1. Sensing Modalities (Mechanical, MEMS, Optical, ISFET, μTAS) 2. Sensing Domains (Air, Water, Noise, Bacterial, Chemical, Kinematic, DNA, Physiological) 3. Functional Characterisation of Sensors o Communication methods – discrete, wired, wireless o Smart Sensors and Sensor Platforms § MSP430 (SHIMMER and telosB motes) § ATmega § PIC 4. Smart Phones as mobile sensor platforms 5. Selecting and specifying sensors Chapter 3 Key Sensor Technology Components – Hardware and Software Overview Chapter Goal: Reader should have a high level understanding of the key hardware and software components, which are necessary for the development of sensors systems and why technologies are selected for specific applications. 1. Overview – Sensor systems 2. MCU’s (TI MSP430, ATmega, PIC) a. ADCs b. Interrupts c. Real-time Clocks 3. Sensor Interfaces a. Digital b. Analog c. I2C 4. Communications – wired and wireless interfaces RS232/485, USB, Ethernet, FieldbusProprietary Short Range Wireless Protocols (e.g. ANT, BodyLAN, Sensium)Standard Short Range Protocols i. IEEE 802.15.6 ii. Bluetooth/Smart Bluetooth iii. 802.15.4 iv. UWB Medium Range i. Wi-Fi 5. Data storage (EEPROM, sd card, data forwarding) 6. Power management and Energy Harvesting 7. Operating Systems and Software Development Environments (SDK’s) Chapter 4 Sensor Network Architectures Chapter Goal: Reader should understand the various approaches to the design of sensor network architectures; scaling from body worn systems, to ambient sensing, to city-scale deployments. The reader should also understand the advantages and disadvantages of current and evolving sensor network architectures. 1. Sensor network architectures o Discrete Sensor o Sensor to aggregator o PAN/WPAN/smart clothing o Pervasive/Ambient sensor networks o Wide area networks (city-wide, country wide) 2. Challenges in developing and deploying sensor networks 3. Current and Proposed Solutions o Remote sensor management o Edge Processing o Power harvesting o New communication standards Chapter 5: Adding Vibrancy to Sensor Data Chapter Goal: Reader should understand the various methods to interpret and display sensor data to the user. They will understand the importance of creating a data analysis plan from the outset, and the different types of data analysis throughout the application stack. 1. Data Literacy – How can we intuitively answer questions with sensor data and contextualise answers 2. Data Quality a. Calibration b. Trust and Repudiation 3. Sensor Fusion – combining sensory data from disparate sources 4. Data Mining 5. Data Visualisation 6. Openness, data integration, virtual sensors 7. Exploiting the power of the cloud Chapter 6: Regulation and Standards Chapter Goal: Reader should understand the key technologies, which impact or influence the development of sensor deployment and applications including the emerging standards and regulatory considerations. 1. Regulatory Standards (US, EU, Japan) : why, which, and how standards impact your application 2. Regulatory Issues: Certification 3. Smartphones Considerations o Privacy and data security 4. Standards Bodies and Industry Groups o Continua Healthcare Alliance o ISO/IEEE 11073 5. Wearable Wireless Health Communication Standards Chapter 7: Biosensing in Everyday Life – Driving Biocontextual Aware Computing Chapter Goal: Reader should understand the social relationships that create opportunities and barriers for widespread, consumer-based biosensing. The reader should understand how the social world is shifting from sensor technologies of “should” to sensor technologies of “could” to facilitate new understandings of health and wellness and drive new methods and practices of personal data sharing. 1. Data Security and Ownership - Sharing and Managing Personal Data 2. Game Changing Pressure for Affordable Healthcare 3. Continuous, Personal Data is Improving Lives 4. Emerging Tech-Empowered Citizens 5. Sensing for Self-Discovery, Culture and Play 6. User feedback/Supporting sustainable human behaviours – leveraging the gaming culture Chapter 8: Development and Deployment of Sensor Technologies for Home and Community Settings Chapter Goal: Reader should understand how to design a sensor deployment for a home or community. The chapter informs the reader how to formulate the research question the deployment will address, how to develop prototypes, and manage and deploy them successful. The chapter will finish with exemplar case studies of real world sensor deployments. Study Design – The Right QuestionHome Deployment ElementsHome Deployment ManagementThe Prototyping Design ProcessCase Studies Chapter 9: Body Worn and Ambient Sensor Applications for Assessment, Monitoring, and Diagnostics Chapter Goal: Reader should at the end of this chapter have an understanding of the key characteristics of how body worn and ambient sensor applications, and how they vary according to the domain in which they are deployed. The reader will be presented with the key challenges faced in each domain, and emerging solutions for these challenges. 1. Drivers and Inhibitors (Incidence of chronic diseases, aging demographics, Adjusting provider compensation, prevention, medical work practice changes) 2. Hospital based sensing for assessment and diagnosis 3. Supervised Assessment and Monitoring in Community Settings 4. Home Based Applications o Clinical grade sensing for patient monitoring o Body worn sensing (e.g. PERS) for monitoring and alerting o Passive sensing for monitoring and alerting (e.g. ADL’s) 5. Key challenges Chapter 10: Wellness, Fitness and Lifestyle Chapter Goal: Reader should understand the key trends in how people use body worn sensors to manage their fitness and wellbeing. Key applications include: sensors for measuring activities in sports performance, activity/weight management and sleep tracking, 1. Drivers and Inhibitors 2. Sports and fitness applications (running, walking cycling, field sports) § Vital signs and physiological parameters § Fitness gaming – Wii Fit, Kinect § muscle movement, body stress levels, speed, distance, location § Fitness Statistics and Analysis 3. Outdoor Activities o Pressure (mountaineer and paragliding) o GPS (hiking, cycling, golf) 4. Obesity and weight management 5. Sleep o Baby Monitoring o Sleep Quality – health and social impacts o Sleep Apnoea Chapter 11: Environmental Monitoring for Health and Wellness Chapter Goal: Reader should understand how sensors and sensor networks are used for environmental monitoring, one of the key emerging applications domains. Apart from disaster monitoring, sensing also has the potential for air quality, weather monitoring, pollution etc.; with benefits for both urban and rural dwellers. 1. Drivers and Inhibitors o Correlations to health impacts 2. Home Sensing o Carbon Monoxide o Smoke Detectors o Passive Infrared (PIR) o Temperature o Sound o Sustainable Living 3. Smart Environments 4. Environmental Parameters (Noise, Water, Bacteria, Air Quality, Radiation, Urban Heat Islands) 5. Weather - Exceptional Event and Disaster Management Intelligence Chapter 12: Conclusions and Future Directions Chapter Goal: Reader should understand the key conclusions that the authors have outlined in the previous chapters. The reader should also gain an understanding of the key trends which will affect future sensor applications and how people will utilise these novel applications in their everyday lives. 1. Summary of the overall conclusions 2. Future Directions for Sensing o Use Centred Healthcare o Citizen centric sensing o Influence of urbanisation on health, wellness and lifestyle choices. o Sustainable human behaviour change