Electrospinning For Advanced Biomedical Applications And Therapies

The main focus of this book is on the development of electrospun membranes for advanced biomedical technologies including tissue engineering and drug delivery devices.Serving as a reference book for the beginner this book also provides an in-depth analysis of the challenges to be overcome in the future. Each section of the book covers not only the developments in the various fields of application of the electrospun meshes, but also the advances required for the successful development of new and high-end biomedical applications.Important areas tackled include:Biomedical applications of the technologySpecific aspects of equipments and materialsSurface characterization and functionalizationIn vitro testing with electrospun meshes. In all of these areas the main achievements, challenges ahead and expert opinions are given, making this book highly unusual in the level of detail covered.

Electrospinning is a versatile and effective technique widely used to manufacture nanofibrous structures from a diversity of materials (synthetic, natural or inorganic). The electrospun nanofibrous meshes’ composition, morphology, porosity, and surface functionality support the development of advanced solutions for many biomedical applications. The Special Issue on “Electrospun Nanofibers for Biomedical Applications” assembles a set of original and highly-innovative contributions showcasing advanced devices and therapies based on or involving electrospun meshes. It comprises 13 original research papers covering topics that span from biomaterial scaffolds’ structure and functionalization, nanocomposites, antibacterial nanofibrous systems, wound dressings, monitoring devices, electrical stimulation, bone tissue engineering to first-in-human clinical trials. This publication also includes four review papers focused on drug delivery and tissue engineering applications.

Electrospinning is a versatile and effective technique widely used to manufacture nanofibrous structures from a diversity of materials (synthetic, natural or inorganic). The electrospun nanofibrous meshes' composition, morphology, porosity, and surface functionality support the development of advanced solutions for many biomedical applications. The Special Issue on “Electrospun Nanofibers for Biomedical Applications” assembles a set of original and highly-innovative contributions showcasing advanced devices and therapies based on or involving electrospun meshes. It comprises 13 original research papers covering topics that span from biomaterial scaffolds' structure and functionalization, nanocomposites, antibacterial nanofibrous systems, wound dressings, monitoring devices, electrical stimulation, bone tissue engineering to first-in-human clinical trials. This publication also includes four review papers focused on drug delivery and tissue engineering applications.

This book presents the development of electrospun materials, fundamental principles of electrospinning process, controlling parameters, electrospinning strategies, and electrospun nanofibrous structures with specific properties for applications in tissue engineering and regenerative medicine, textile, water treatment, sensor, and energy fields. This book can broadly be divided into three parts: the first comprises basic principles of electrospinning process, general requirements of electrospun materials and advancement in electrospinning technology, the second part describes the applications of electrospun materials in different fields and future prospects, while the third part describes applications that can be used in advanced manufacturing based on conjoining electrospinning and 3D printing. Electrospinning is the most successful process for producing functional nanofibers and nanofibrous membranes with superior chemical and physical properties. The unique properties of electrospun materials including high surface to volume ratio, flexibility, high mechanical strength, high porosity, and adjustable nanofiber and pore size distribution make them potential candidates in a wide range of applications in biomedical and engineering areas. Electrospinning is becoming more efficient and more specialized in order to produce particular fiber types with tunable diameter and morphology, tunable characteristics, having specific patterns and 3D structures. With a strong focus on fundamental materials science and engineering, this book provides systematic and comprehensive coverage of the recent developments and novel perspectives of electrospun materials. This comprehensive book includes chapters that discuss the latest and emerging applications of nanofiber technology in various fields, specifically in areas such as wearable textile, biomedical applications, energy generation and storage, water treatment and environmental remediation, and sensors such as biomarkers in healthcare and biomedical engineering. Despite all these advancements, there are still challenges to be addressed and overcome for nanofiber technology to move towards maturation.

This is a timely, an informative, an interesting, and a well-managed book. The book not only offers an in-depth review of the current status of the knowledge of electrospinning and its biomedical applications but also discusses the emerging ideas and features, both from the East and West, with a focus on the needless electrospinning for the production of uniform fibers. The book is equally helpful to the experts of this field, who wish to enhance their understanding of the emerging technologies, and to the new comers, who can use this book as a reference.

This volume deals with the various fabrication techniques, surface functionalization and biomedical applications of polymeric fibers possessing different scale and structure. It provides an overview of fabrication techniques such as Co-axial, Centrifugal, Melt and Yarning to procure multiscale, tubular and layered fibrous scaffold employed for biomedical applications. The chapters in this volume discusse the surface/chemical functionalization of fibers which enhance the biological properties of the fibrous scaffolds as well as the development of hybrid, layered and external stimuli-responsive fibrous scaffolds that hold potential application in biosensor and other biomedical fields. In addition, recent advances and applications of polymeric multiscale fibers in tissue engineering, regenerative medicine and drug delivery are presented. The potential use of fibrous scaffolds in bone, neural, tendon/ligament and cardiac tissue engineering, nanofibers as an antimicrobial wound dressing, employed in cancer theragnostics and in the treatment of skin/periodontal infections are discussed. The volume provides expert knowledge on the fabrication techniques, development of different scale and hybrid structure fibers, surface functionalization, layered and external stimuli responsive fibrous scaffolds. It will be beneficial to material/biomaterials scientists, bioengineering and biotechnologists by providing a better understanding on the subject of the innovative applications of fibrous scaffolds in drug delivery, tissue engineering, wound dressings and regenerative medicine.

Nanofibers are possible solutions for a wide spectrum of research and commercial applications and utilizing inexpensive bio-renewable and agro waste materials to produce nanofibers can lower manufacturing cost via electrospinning. This book explains synthesis of green, biodegradable, and environmentally friendly nanofibers from bioresources, their mechanical and morphological characteristics along with their applications across varied areas. It gives an elaborate idea on conductive polymers for tissue engineering application as well. Features: Provides insight about electrospun nanofibers from green, biodegradable and environmentally friendly bio resources. Reviews surface characterization of electrospun fibers. Covers diversified applications such as cancer treatment, COVID-19 solutions, food packaging applications, textile materials, and flexible electronic devices. Describes the combined use of 3D printing and electrospinning for tissue engineering scaffolds. Includes Melt electrospinning technique and its advantages over Solution electrospinning This book aims at Researchers and Graduate Students in Material Science and Engineering, Environmental Engineering, Chemical Engineering, Electrical Engineering, Mechanical Engineering, and Biomedical Engineering.

Biomedical Applications of Electrospinning and Electrospraying describes the principles and laboratory set up for electrospinning and electrospraying, addressing a range of biomedical applications. Sections cover novel combinational approaches, such as electrospinning/spraying and 3D printing. Electrospinning has evolved from being a technique to prepare random networks of textile fibers to a technique to fabricate highly ordered patterns of biomedical materials of defined scale. The technological advancements in recent years with regard to the way the jet is facilitated, how the jet path is controlled, and how the fibers are collected have provided invaluable insights into controlled fabrication of a material of choice. Additionally, the electrospray technique has also evolved from being a technique to prepare food formulations to a technique to prepare cell encapsulated beads for transplantation in clinics. Several innovations in this line, such as those leading to core-shell materials have tremendously changed the way the technique is used. Thus, a combinational approach using electrospinning, electrospraying and 3D printing has emerged. Introduces electrospinning and electrospraying concepts and describes state-of-the-art methodologies Provides comprehensive coverage of electrospun/spray materials in drug delivery, tissue engineering and biosensor applications Presents details of instrumentation involved, along with novel devices for bench to bedside translation, Covers novel combinational approaches using electrospinning, electrospraying and 3D printingIntroduces electrospinning and electrospraying concepts and describes state-of-the-art methodologies Provides comprehensive coverage of electrospun/spray materials in drug delivery, tissue engineering and biosensor applications Presents details of instrumentation involved, along with novel devices for bench to bedside translation Covers novel combinational approaches using electrospinning, electrospraying and 3D printing