Fast Facts Multiple Sclerosis

Multiple sclerosis (MS) is a leading cause of disability in young adults, carrying a considerable individual and societal economic burden. The development of disease-modifying therapies and updates to diagnostic criteria are leading us into a new era for MS management, both in the earliest disease phases and progressive MS. In this completely revised/fully updated edition of Fast Facts: Multiple Sclerosis, we present the most recent evidence on disease pathogenesis and all clinical aspects of the condition, as well as the latest on disease-modifying therapies and other potential treatments. Given the need for multidisciplinary management of MS, we have written this resource for the benefit of all health professionals involved in MS care. Table of Contents: • Epidemiology and genetics • Pathology • The clinical picture • Treatment of relapses and symptoms • Disease-modifying treatment • Emerging therapies • Special MS populations • Lifestyle considerations and the multidisciplinary team • Advanced MS

The latest evidence on disease pathomechanisms, clinical aspects and modern diagnostic criteria, a review of novel therapies is also incorporated.

Since the last edition of this book, 'no evidence of disease activity' (NEDA) has been proposed as a new treatment target, early data on the first pharmacological treatments for progressive MS have emerged, and the first remyelination trial has shown positive effects on nerve repair. It is with this sense of optimism that the authors of 'Fast Facts: Multiple Sclerosis' have detailed the latest developments for use in clinical practice by all members of the multidisciplinary team, including: • a concise overview of investigations and modern diagnostic criteria • a holistic approach to all signs and symptoms, and proactive relapse management • the latest disease-modifying drugs, including when to treat, choice of drug and risk versus benefit. With case histories that will help to guide treatment decisions, discussion of the special considerations for MS during pregnancy, and in children and the elderly, and a detailed outline of emerging therapies, this book will benefit all healthcare professionals involved in the care of patients with this complex disease.

Difficulties with cognition are an assault on ourselves and our identities. In the context of the unpredictable and often progressive course of multiple sclerosis (MS), reductions in information processing, memory function, and other mental faculties can be a heavy burden for people with MS (PwMS). Fast Facts: Cognition in Multiple Sclerosis was written to support healthcare professionals (HCPs) working in MS clinics and other services. Each chapter is designed to be read as a standalone text. The authors aim with this book is to bring increased understanding and confidence to everyone facing the challenges of dealing with cognitive impairment linked to MS. Table of Contents: • What do cognitive difficulties mean for people with MS and their caregiver partners? • MS cognitive difficulties and their impacts • How do MS cognitive deficits relate to other variables? • Assessment strategies • MS clinic management of cognition I: healthcare professional information and action • MS clinic management of cognition II: people with MS’ engagement, information, and action • Additional specialist input • Difficult conversations

Multiple sclerosis'MS'strikes about one in a thousand North Americans, usually in early adulthood, when they are building careers and starting families. Because the disease involves the central nervous system, its effects are wide-ranging and difficult to predict. Until the 1990s, we could treat some symptoms of MS but not the disease itself. Now we have several drugs that work against MS, and others are being developed. We still can't cure MS, but we can slow its progress and diminish its effects. This fourth edition of Multiple Sclerosis: The Facts You Need is a comprehensive guide to living with MS, supported by diagrams, case histories, a drug table, and an extensive list of helpful books and organizations. Topics include: '¢ What MS is, and who gets it '¢ How MS is diagnosed '¢ Why the disease affects different people in different ways '¢ How 'relapsing-remitting' MS differs from 'progressive MS' '¢ How people with MS, and their families, can adapt their homes, careers, and lifestyles to cope with the disease '¢ Which treatments work, which don't, and what help is on the horizon Combining authoritative medical advice and practical hands-on tips, Multiple Sclerosis: The Facts You Need is an invaluable guide for anyone affected, directly or indirectly, by this complex disease. Praise for Multiple Sclerosis : 'With so much new scientific information emerging about multiple sclerosis, this book's clear and comprehensive account of these developments is invaluable'¦. A 'must' for persons with MS and their families.' 'William J. McIlroy, MD, FRCPC, National Medical Advisor, MS Society of Canada

The term ‘bladder disorders’ encompasses a number of lower urinary tract dysfunctions and abnormalities that negatively affect quality of life. Some can cause considerable morbidity and even mortality. Three internationally recognized authors with different areas of expertise – a leading British urogynecologist, a chief of urology listed as one of America's "Best Doctors", and an American continence expert - have ensured that this second edition of 'Fast Facts: Bladder Disorders' is internationally relevant to the non-specialist working within a multidisciplinary team. Based on robust evidence and clinical experience, and supported by superb illustrations, this fact-filled handbook covers everything you will need to recognize the symptoms and signs of a wide range of bladder disorders from urinary incontinence to hematuria to UTIs. It also provides an excellent overview of basic pathophysiology, and will help practitioners initiate screening and assessment and, where appropriate, treatment. Contents: • Anatomy and function of the urinary system • Assessment • Urinary incontinence • The overactive bladder and urgency incontinence • Voiding problems • Hematuria • Urinary tract infections and cystitis • Nocturnal symptoms • Neuropathic bladder dysfunction • Special considerations • Useful resources

All health professionals, regardless of specialty, will care for patients with pain that has persisted for more than 6 months. This fully updated fourth edition of 'Fast Facts: Chronic and Cancer Pain', written by two internationally renowned experts in the field, is designed to bring busy health professionals up to speed with the latest information in this area, including: • Easy-to-read overviews of pain mechanisms • A practical approach to pain assessment • Developments in stepped care and multimodal management • The latest thinking on opioids With health services around the world responding to calls to improve the management of painful long-term conditions, develop preventive and cost-effective solutions, and respond to patient choice and voice, this easy-to-read fact-packed book is essential reading for all GPs, nurses, junior hospital doctors, physical therapists, clinical psychologists, occupational therapists, pharmacists, medical specialists and medical students wanting - and needing - to know more. Contents: • Definitions and mechanisms • Assessment of pain • Treatment options • Trigeminal neuralgia • Complex regional pain syndrome • Diabetic and postherpetic neuropathic pain Central pain • Persistent postsurgical pain • Cancer pain • Musculoskeletal pain • Visceral pain • Headache