Finely Tuned

A finely tuned regulation of gene expression is essential for shaping the nervous system and for maintaining its homeostasis throughout life. Disruptions in gene regulation can impact brain development and physiology in ways that contribute to diverse pathologies. The master orchestrators of gene activity in the nucleus are transcription factors, proteins that recognize and bind to specific DNA motifs in regulatory regions and drive changes in gene expression. Transcription factors act with the help of other co-factor proteins, including components of the Mediator complex, histone modifying enzymes, chromatin modelers, and DNA methylases. In addition, transcription factor activity in the nervous system can be modulated by extracellular signals, including growth factors, hormones, neuropeptides and neurotransmitters that activate specific receptors and intracellular transduction pathways. An in-depth understanding of the mechanisms of transcription regulation is needed in order to better describe how each element, from genes to cells, defines and maintains identities and functionalities in the healthy and diseased brain. This Research Topic is oriented to developing an integrative view about transcription regulation within the nervous system, focusing on developmental and homeostatic processes, dysregulation in functionality and expression levels and consequent associated pathologies such as neurodevelopmental disorders, brain tumors, and neurodegenerative diseases. Transcription regulation investigations will specifically focus on transcription factors that belong to the bHLH (e.g. NeuroD), homeobox (e.g. Islet, Pax, Rax, and Lhx) and CREB families, and on their roles over defined nervous system areas: cerebral cortex, thalamic and hypothalamic areas, interacting with the developing brain.

Bursting with comedy and peculiarity, this collection of short stories explores the world of those living their Generation-X lives on the fringes of society. From a loner who uses mosh pits as a confessional to a cross-dresser prowling the aisles of the local supermarket, this work follows these characters as they navigate the universe in refreshing and unexpected ways.

Highly Sensitive People and Empaths: Finding peace and empowerment for those who feel too much. "Don't be so sensitive." "Just get it over it." "You're just so intense" If you're a highly sensitive person or an empath, you've probably heard these statements many times. Maybe you feel different because you're just more tuned in and sensitive than most people you know. You notice things others don't. You can easily pick up on the mood of the room. You're bothered by small irritations, noise, and bright light. Sometimes the world just feels overwhelming, and you wonder what is wrong with you. The good news? Being highly sensitive isn't weird or wrong. It's a perfectly normal trait held by 15-20% of the population. The Little-Known Power of Being Finely Tuned As a sensitive person, you may believe you're weak and less resilient than others. This belief may have been reinforced all of your life, but nothing could be further from the truth. Highly sensitive people and empaths are gifted with unique skills making them more creative, intuitive, conscientious, and empathic. They are evolutionarily hard-wired this way to benefit the larger community, as they are the first to notice and respond to subtitles, moods, and danger. They are also first to feel deeper, positive emotions as well. Thriving Daily As a Sensitive It can be daunting to live in a world that feels overwhelming and insensitive, especially when others don't understand or appreciate you. With self-awareness, mindful communication, and proper management of your environment, you'll not only survive as a sensitive, but you'll thrive in ways you never anticipated. Life will be more enriching and joyful, and your traits as a sensitive person can be leveraged to squeeze much more fulfillment from life as you learn to accept and appreciate your amazing personality. Order: Finely Tuned: How To Thrive As A Highly Sensitive Person or Empath Finely Tuned is a guidebook for those with highly sensitive, empathic natures seeking relief from the pain of being misunderstood and wanting to reclaim life on their own terms, sensitivities and all. It spells out exactly why you have this keenly sensitive nature, and how you are perfectly normal in your traits and needs. It teaches you skills for understanding yourself, communicating your traits with others, and redesigning your life around your beautiful gifts so that you and others can fully benefit from them. Want to know more? Order and learn how to embrace being a highly sensitive person or empath today. Scroll to the top of the page and select the "buy" button.

One football star. One overworked mom. One deal to secure both of their dreams. Single mom Jessica McWilliams has spent her entire adult life uncertain and untethered. Until now. She’s crafted a two-step plan to ensure a stable future for her and her son. One, finish her degree—even if she is the oldest person in every class. Two, show her boss that she’s indispensable and ready to be promoted to her dream job. All she needs is grit, determination . . . and possibly a fairy godmother to sprinkle a few more hours in her day. Nashville Knights star football player Mick Lanuola lives by a single rule: if it’s worth doing, it’s worth doing well. Hall-of-Fame well. That means finishing his career at the top of his game, growing his fledgling charity into a countrywide organization, and making sure his parents and sisters have all their needs met. Everything else can wait until after retirement. But when a chance meeting leads to a viral photo, Jessica and Mick grudgingly accept an unconventional proposition. Seven weeks of faking a relationship seems a fair trade to get them each closer to their dreams. Until their just-for-the-media meetings turn into flirty dinner dates and chemistry-filled charity events. Making them wonder if they’re still playing a game or if all the rules have changed. Linked to the award-winning Storyhill Musicians series, Fine Tuned is a novella for fans of sports romance, fake dating, and doing whatever it takes to reach your dreams while helping the people you love the most.

In this book were going to be talking about the 2 predominant and powerful communication styles which should improve your effectiveness as a communicator, persuader or as a leader. Especially CRUCIAL to folks entering a new group of people where the perfect calibration of strength and approachability is crucial in gaining a solid foothold in the group. People are too hung up on techniques and tactics without realizing there are actually 2 styles of communication one could shift into, to hit the sweet spot 'and maximize communication and relationship effectiveness not to mention persuasiveness and compliance, from your peers and subordinates! Choosing the wrong one at the wrong time or to the wrong people? You lose respect, authority and they won't follow or believe anything you say! Even worse...they'll shun you out PERMANENTLY for coming in too strong or too weak and mis-calibrated! Introduction The Newbie and his homework New house, new rules! Knowing the players Credibility building Chipping away Technical Experts and Know -it- alls Pockets of powers Not created equal Being the force of change Communication between the sexes Male psychology Female psychology Initial communication assessment phase in business Direct style communications Group talks and Direct style Authority and Decisiveness Arguments and Verbal jousts Too Controlling Hinting your power Power is just in the mind Weak communication Alphas and Betas Too stiff Not listening Flexibility From the edge, inwards Indirect style Language from the edge Asking questions Indirect requiring more direct means Arguments Protection of Egos Calibration and balance is key Direct style transitioning to Indirect Indirect style transitioning to Direct Covering a topic Power plays Changing to Direct style mindset Improving your communication style Inner critique Recording yourself Talking in front of the mirror External critiques Culture and a larger vocabulary Tips to improve your techniques NLP Influence Cautionary tales Practice, practice, practice! Safe place Inner game requirements for change